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cbl Cbl proto-oncogene, E3 ubiquitin protein ligase [ Oryzias latipes (Japanese medaka) ]

Gene ID: 101170289, updated on 8-Mar-2024

Summary

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Gene symbol
cbl
Gene description
Cbl proto-oncogene, E3 ubiquitin protein ligase
See related
EnsemblRapid:ENSORLG00000007611
Gene type
protein coding
RefSeq status
MODEL
Organism
Oryzias latipes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae; Oryzias
Orthologs
human zebrafish all
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Genomic context

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Location:
chromosome: 13
Exon count:
16
Annotation release Status Assembly Chr Location
103 current ASM223467v1 (GCF_002234675.1) 13 NC_019871.2 (16359082..16389208)
102 previous assembly ASM31367v1 (GCF_000313675.1) 13 NC_019871.1 (15792467..15819997)

Chromosome 13 - NC_019871.2Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor (GEF) 12a Neighboring gene glutamate receptor, ionotropic, kainate 4 Neighboring gene melanoma cell adhesion molecule b Neighboring gene ring finger protein 26

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphotyrosine residue binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of epidermal growth factor-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase CBL

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Oryzias latipes Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM223467v1 Primary Assembly

Genomic

  1. NC_019871.2 Reference ASM223467v1 Primary Assembly

    Range
    16359082..16389208
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004075681.4 → XP_004075729.1  E3 ubiquitin-protein ligase CBL

    UniProtKB/TrEMBL
    A0A3P9LJS5, H2LTW9
    Related
    ENSORLP00000047285.1, ENSORLT00000085902.1
    Conserved Domains (5) summary
    cd09920
    Location:240 → 336
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14393
    Location:897 → 936
    UBA_c-Cbl; UBA domain found in E3 ubiquitin-protein ligase Cbl and similar proteins
    pfam02262
    Location:38 → 159
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:163 → 246
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    pfam13920
    Location:363 → 412
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
Nucleotide Protein
Heading Accession and Version

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