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cbl Cbl proto-oncogene, E3 ubiquitin protein ligase [ Danio rerio (zebrafish) ]

Gene ID: 492364, updated on 9-Sep-2025
Official Symbol
cblprovided by ZNC
Official Full Name
Cbl proto-oncogene, E3 ubiquitin protein ligaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-041114-207
See related
Ensembl:ENSDARG00000009958 AllianceGenome:ZFIN:ZDB-GENE-041114-207
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:92560; wu:fd16a12
Summary
Predicted to enable receptor tyrosine kinase binding activity and ubiquitin protein ligase activity. Acts upstream of or within definitive hemopoiesis. Predicted to be active in membrane raft and plasma membrane. Used to study Noonan syndrome and myeloproliferative neoplasm. Human ortholog(s) of this gene implicated in acute myeloid leukemia; congestive heart failure; juvenile myelomonocytic leukemia; lung non-small cell carcinoma; and myeloid neoplasm. Orthologous to human CBL (Cbl proto-oncogene). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
human mouse all
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See cbl in Genome Data Viewer
Location:
chromosome: 15
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 15 NC_133190.1 (25674673..25731844)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 15 NC_007126.7 (23208045..23266364)

Chromosome 15 - NC_133190.1Genomic Context describing neighboring genes Neighboring gene glutamate receptor, ionotropic, kainate 4 Neighboring gene uncharacterized LOC141377838 Neighboring gene dynein regulatory complex subunit 12 homolog Neighboring gene uncharacterized LOC141377839 Neighboring gene melanoma cell adhesion molecule b Neighboring gene ring finger protein 26

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. The c-Cbl ubiquitin ligase regulates nuclear β-catenin and angiogenesis by its tyrosine phosphorylation mediated through the Wnt signaling pathway. Shivanna S, et al. J Biol Chem, 2015 May 15. PMID 25784557, Free PMC Article
  2. Precise base editing for the in vivo study of developmental signaling and human pathologies in zebrafish. Rosello M, et al. Elife, 2021 Feb 12. PMID 33576334, Free PMC Article
  3. A point mutation of zebrafish c-cbl gene in the ring finger domain produces a phenotype mimicking human myeloproliferative disease. Peng X, et al. Leukemia, 2015 Dec. PMID 26104663, Free PMC Article
  4. Somatic mutagenesis with a Sleeping Beauty transposon system leads to solid tumor formation in zebrafish. McGrail M, et al. PLoS One, 2011 Apr 21. PMID 21533036, Free PMC Article
  5. Copper Regulates the Susceptibility of Zebrafish Larvae to Inflammatory Stimuli by Controlling Neutrophil/Macrophage Survival. Chen M, et al. Front Immunol, 2019. PMID 31787979, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. novel mechanism for the regulation of active nuclear beta-catenin by c-Cbl and its critical role in angiogenesis.
    Title: The c-Cbl ubiquitin ligase regulates nuclear β-catenin and angiogenesis by its tyrosine phosphorylation mediated through the Wnt signaling pathway.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ephrin receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphotyrosine residue binding IEA
Inferred from Electronic Annotation
more info
  
enables receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within definitive hemopoiesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of epidermal growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane raft IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
E3 ubiquitin-protein ligase CBL
Names
Cas-Br-M (murine) ecotropic retroviral transforming sequence
NP_001007331.1
XP_005157636.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007330.1 → NP_001007331.1  E3 ubiquitin-protein ligase CBL

    See identical proteins and their annotated locations for NP_001007331.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085671
    UniProtKB/TrEMBL
    Q5U376
    Related
    ENSDARP00000027963.7, ENSDART00000006085.8
    Conserved Domains (5) summary
    cd09920
    Location:240 → 336
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:365 → 407
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14393
    Location:864 → 903
    UBA_c-Cbl; UBA domain found in E3 ubiquitin-protein ligase Cbl and similar proteins
    pfam02262
    Location:38 → 159
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:163 → 246
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133190.1 Reference GRCz12tu Primary Assembly

    Range
    25674673..25731844
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005157579.6 → XP_005157636.1  E3 ubiquitin-protein ligase CBL isoform X1

    UniProtKB/TrEMBL
    A0A8M2B4G4
    Conserved Domains (5) summary
    cd09920
    Location:240 → 336
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:365 → 407
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14393
    Location:863 → 902
    UBA_c-Cbl; UBA domain found in E3 ubiquitin-protein ligase Cbl and similar proteins
    pfam02262
    Location:38 → 159
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:163 → 246
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
Nucleotide Protein Strain
Heading Accession and Version

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