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PDK2 pyruvate dehydrogenase kinase 2 [ Ovis aries (sheep) ]

Gene ID: 101108929, updated on 6-Jun-2024

Summary

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Gene symbol
PDK2
Gene description
pyruvate dehydrogenase kinase 2
See related
EnsemblRapid:ENSOARG00020011584
Gene type
protein coding
RefSeq status
MODEL
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Orthologs
human mouse all
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Genomic context

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See PDK2 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 11 NC_056064.1 (36278810..36295547, complement)

Chromosome 11 - NC_056064.1Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1 regulatory subunit 9B Neighboring gene sterile alpha motif domain containing 14 Neighboring gene integrin subunit alpha 3 Neighboring gene distal-less homeobox 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056064.1 Chromosome 11 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables pyruvate dehydrogenase (acetyl-transferring) kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
pyruvate dehydrogenase kinase, isozyme 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UI_Ramb_v3.0 Primary Assembly

Genomic

  1. NC_056064.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Range
    36278810..36295547 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_027974696.2 → XP_027830497.1  pyruvate dehydrogenase kinase, isozyme 2 isoform X8

    Related
    ENSOARP00020045522.1, ENSOART00020046097.1

  2. XM_060395544.1 → XP_060251527.1  pyruvate dehydrogenase kinase, isozyme 2 isoform X6

    UniProtKB/TrEMBL
    W5P5J4
    Related
    ENSOARP00020014573.2, ENSOART00020017651.2

  3. XM_004012777.5 → XP_004012826.1  pyruvate dehydrogenase kinase, isozyme 2 isoform X2

    See identical proteins and their annotated locations for XP_004012826.1

    UniProtKB/TrEMBL
    A0A6P3EA71, W5P5J4
    Related
    ENSOARP00020055804.1, ENSOART00020052052.1
    Conserved Domains (2) summary
    cd16929
    Location:196 → 361
    HATPase_PDK-like; Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains
    pfam10436
    Location:30 → 192
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

  4. XM_060395543.1 → XP_060251526.1  pyruvate dehydrogenase kinase, isozyme 2 isoform X5

    UniProtKB/TrEMBL
    W5P5J4

  5. XM_012185922.3 → XP_012041312.1  pyruvate dehydrogenase kinase, isozyme 2 isoform X1

    See identical proteins and their annotated locations for XP_012041312.1

    UniProtKB/TrEMBL
    W5P5J4
    Conserved Domains (3) summary
    smart00387
    Location:253 → 372
    HATPase_c; Histidine kinase-like ATPases
    COG0642
    Location:228 → 380
    BaeS; Signal transduction histidine kinase [Signal transduction mechanisms]
    pfam10436
    Location:30 → 203
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

  6. XM_012185920.4 → XP_012041310.1  pyruvate dehydrogenase kinase, isozyme 2 isoform X8

    See identical proteins and their annotated locations for XP_012041310.1

    Related
    ENSOARP00020063697.1, ENSOART00020045321.1
    Conserved Domains (3) summary
    smart00387
    Location:189 → 308
    HATPase_c; Histidine kinase-like ATPases
    COG0642
    Location:164 → 316
    BaeS; Signal transduction histidine kinase [Signal transduction mechanisms]
    pfam10436
    Location:1 → 139
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

  7. XM_060395545.1 → XP_060251528.1  pyruvate dehydrogenase kinase, isozyme 2 isoform X7

  8. XM_027974694.2 → XP_027830495.1  pyruvate dehydrogenase kinase, isozyme 2 isoform X4

    UniProtKB/TrEMBL
    W5P5J4

  9. XM_012185919.5 → XP_012041309.1  pyruvate dehydrogenase kinase, isozyme 2 isoform X3

    See identical proteins and their annotated locations for XP_012041309.1

    UniProtKB/TrEMBL
    W5P5J4
    Conserved Domains (3) summary
    smart00387
    Location:237 → 356
    HATPase_c; Histidine kinase-like ATPases
    COG0642
    Location:212 → 364
    BaeS; Signal transduction histidine kinase [Signal transduction mechanisms]
    pfam10436
    Location:27 → 187
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
Nucleotide Protein Strain
Heading Accession and Version

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