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GRB14 growth factor receptor bound protein 14 [ Ovis aries (sheep) ]

Gene ID: 101105217, updated on 8-Mar-2024

Summary

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Gene symbol
GRB14
Gene description
growth factor receptor bound protein 14
See related
EnsemblRapid:ENSOARG00020009236
Gene type
protein coding
RefSeq status
MODEL
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 2 NC_056055.1 (144980078..145105415)

Chromosome 2 - NC_056055.1Genomic Context describing neighboring genes Neighboring gene cordon-bleu WH2 repeat protein like 1 Neighboring gene uncharacterized LOC121818711 Neighboring gene large ribosomal subunit protein uL1-like Neighboring gene fidgetin, microtubule severing factor Neighboring gene uncharacterized LOC132659313

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056055.1 Chromosome 2 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
growth factor receptor-bound protein 14

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UI_Ramb_v3.0 Primary Assembly

Genomic

  1. NC_056055.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Range
    144980078..145105415
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004004651.6 → XP_004004700.2  growth factor receptor-bound protein 14 isoform X1

    UniProtKB/TrEMBL
    A0A6P3E1D5, W5P757
    Related
    ENSOARP00020011762.1, ENSOART00020014261.2
    Conserved Domains (4) summary
    cd10414
    Location:433 → 540
    SH2_Grb14; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 14 (Grb14) proteins
    cd01259
    Location:230 → 351
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16139
    Location:107 → 191
    RA_GRB14; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 14
    pfam08947
    Location:370 → 414
    BPS; BPS (Between PH and SH2)

  2. XM_042243799.2 → XP_042099733.1  growth factor receptor-bound protein 14 isoform X2

    UniProtKB/TrEMBL
    W5P757
    Conserved Domains (3) summary
    cd10414
    Location:406 → 513
    SH2_Grb14; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 14 (Grb14) proteins
    cd01259
    Location:230 → 342
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16139
    Location:107 → 191
    RA_GRB14; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 14

  3. XM_042243800.2 → XP_042099734.1  growth factor receptor-bound protein 14 isoform X3

    UniProtKB/TrEMBL
    W5P757
    Conserved Domains (3) summary
    cd01259
    Location:230 → 351
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16139
    Location:107 → 191
    RA_GRB14; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 14
    cl15255
    Location:433 → 480
    SH2; Src homology 2 (SH2) domain

  4. XM_042243801.2 → XP_042099735.1  growth factor receptor-bound protein 14 isoform X4

    Conserved Domains (2) summary
    cd01259
    Location:230 → 351
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16139
    Location:107 → 191
    RA_GRB14; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 14

  5. XM_012135485.5 → XP_011990875.1  growth factor receptor-bound protein 14 isoform X5

    See identical proteins and their annotated locations for XP_011990875.1

    UniProtKB/TrEMBL
    W5P757
    Related
    ENSOARP00020051165.1, ENSOART00020046647.1
    Conserved Domains (4) summary
    cd10414
    Location:346 → 453
    SH2_Grb14; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 14 (Grb14) proteins
    cd01259
    Location:143 → 264
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16139
    Location:20 → 104
    RA_GRB14; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 14
    pfam08947
    Location:283 → 327
    BPS; BPS (Between PH and SH2)
Nucleotide Protein Strain
Heading Accession and Version

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