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Grb14 growth factor receptor bound protein 14 [ Mus musculus (house mouse) ]

Gene ID: 50915, updated on 13-Oct-2022

Summary

Official Symbol
Grb14provided by MGI
Official Full Name
growth factor receptor bound protein 14provided by MGI
Primary source
MGI:MGI:1355324
See related
Ensembl:ENSMUSG00000026888 AllianceGenome:MGI:1355324
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables protein-macromolecule adaptor activity. Predicted to be involved in insulin receptor signaling pathway; negative regulation of insulin receptor signaling pathway; and negative regulation of meiotic cell cycle process involved in oocyte maturation. Predicted to act upstream of or within signal transduction. Predicted to be located in Golgi apparatus and endosome. Predicted to be active in cytoplasm and plasma membrane. Is expressed in male reproductive gland or organ; nervous system; and nucleus pulposus. Orthologous to human GRB14 (growth factor receptor bound protein 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart adult (RPKM 19.5), ovary adult (RPKM 12.9) and 18 other tissues See more
Orthologs
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Genomic context

See Grb14 in Genome Data Viewer
Location:
2; 2 C1.3
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (64742820..64853354, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (64912476..65022766, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene Parkinson disease 7 domain containing 1 pseudogene Neighboring gene predicted gene 13578 Neighboring gene U7 small nuclear RNA Neighboring gene Cobl-like 1 Neighboring gene predicted gene 13594

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables molecular function inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
growth factor receptor-bound protein 14
Names
GRB14 adapter protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001412538.1NP_001399467.1  growth factor receptor-bound protein 14 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL928703, AL929129
  2. NM_001412539.1NP_001399468.1  growth factor receptor-bound protein 14 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL928703, AL929129
  3. NM_001412540.1NP_001399469.1  growth factor receptor-bound protein 14 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL928703, AL929129
  4. NM_016719.2NP_057928.1  growth factor receptor-bound protein 14 isoform 1

    See identical proteins and their annotated locations for NP_057928.1

    Status: VALIDATED

    Source sequence(s)
    AL928703, AL929129
    Consensus CDS
    CCDS16071.1
    UniProtKB/Swiss-Prot
    Q9CR03, Q9JLM9
    UniProtKB/TrEMBL
    A2ASX2
    Related
    ENSMUSP00000028252.8, ENSMUST00000028252.14
    Conserved Domains (5) summary
    cd01787
    Location:104188
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10414
    Location:431538
    SH2_Grb14; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 14 (Grb14) proteins
    cd01259
    Location:228349
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam00169
    Location:233339
    PH; PH domain
    pfam08947
    Location:368412
    BPS; BPS (Between PH and SH2)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    64742820..64853354 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162369.1XP_036018262.1  growth factor receptor-bound protein 14 isoform X1

    Conserved Domains (4) summary
    cd01259
    Location:228349
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:368412
    BPS; BPS (Between PH and SH2)
    cl15255
    Location:431459
    SH2; Src homology 2 (SH2) domain
    cl28922
    Location:105189
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  2. XM_036162370.1XP_036018263.1  growth factor receptor-bound protein 14 isoform X3

    Conserved Domains (4) summary
    cd10414
    Location:343450
    SH2_Grb14; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 14 (Grb14) proteins
    cd01259
    Location:140261
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:280324
    BPS; BPS (Between PH and SH2)
    cl28922
    Location:19101
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  3. XM_006499883.5XP_006499946.1  growth factor receptor-bound protein 14 isoform X2

    Conserved Domains (4) summary
    cd10414
    Location:346453
    SH2_Grb14; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 14 (Grb14) proteins
    cd01259
    Location:143264
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:283327
    BPS; BPS (Between PH and SH2)
    cl28922
    Location:20104
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold