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FGA fibrinogen alpha chain [ Ovis aries (sheep) ]

Gene ID: 101102090, updated on 8-Mar-2024

Summary

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Gene symbol
FGA
Gene description
fibrinogen alpha chain
See related
EnsemblRapid:ENSOARG00020016865
Gene type
protein coding
RefSeq status
MODEL
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 17
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 17 NC_056070.1 (3026610..3037578)

Chromosome 17 - NC_056070.1Genomic Context describing neighboring genes Neighboring gene lecithin retinol acyltransferase Neighboring gene fibrinogen gamma chain Neighboring gene fibrinogen beta chain Neighboring gene pleiotropic regulator 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056070.1 Chromosome 17 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables extracellular matrix structural constituent IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in blood coagulation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in blood coagulation, common pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in fibrinolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of endothelial cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in platelet activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in platelet aggregation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of heterotypic cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of peptide hormone secretion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein polymerization IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of fibrinogen complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
fibrinogen alpha chain

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UI_Ramb_v3.0 Primary Assembly

Genomic

  1. NC_056070.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Range
    3026610..3037578
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004017183.5 → XP_004017232.4  fibrinogen alpha chain

    UniProtKB/TrEMBL
    W5Q5H8
    Related
    ENSOARP00020053140.1, ENSOART00020025894.2
    Conserved Domains (3) summary
    PHA03307
    Location:269 → 405
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00087
    Location:602 → 835
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    TIGR04523
    Location:77 → 206
    Mplasa_alph_rch; helix-rich Mycoplasma protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P68214.1 GenPept UniProtKB/Swiss-Prot:P68214

Gene LinkOut

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