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MASP2 MBL associated serine protease 2 [ Felis catus (domestic cat) ]

Gene ID: 101099568, updated on 8-Mar-2024

Summary

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Official Symbol
MASP2
Official Full Name
MBL associated serine protease 2
Primary source
VGNC:VGNC:68191
See related
EnsemblRapid:ENSFCTG00005031960
Gene type
protein coding
RefSeq status
MODEL
Organism
Felis catus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: C1
Exon count:
13
Annotation release Status Assembly Chr Location
105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) C1 NC_058375.1 (7957767..7974943, complement)
104 previous assembly Felis_catus_9.0 (GCF_000181335.3) C1 NC_018730.3 (7986546..7999960, complement)

Chromosome C1 - NC_058375.1Genomic Context describing neighboring genes Neighboring gene castor zinc finger 1 Neighboring gene uncharacterized LOC109502081 Neighboring gene uncharacterized LOC123379352 Neighboring gene TAR DNA binding protein Neighboring gene exosome component 10 Neighboring gene spermidine synthase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in complement activation, lectin pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
mannan-binding lectin serine protease 2
Names
mannan binding lectin serine peptidase 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference F.catus_Fca126_mat1.0 Primary Assembly

Genomic

  1. NC_058375.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

    Range
    7957767..7974943 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003989575.4 → XP_003989624.2  mannan-binding lectin serine protease 2 isoform X1

    UniProtKB/TrEMBL
    M3VU02
    Related
    ENSFCTP00005059748.1, ENSFCTT00005088608.1
    Conserved Domains (5) summary
    cd00033
    Location:315 → 376
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00042
    Location:43 → 149
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    smart00179
    Location:153 → 191
    EGF_CA; Calcium-binding EGF-like domain
    cd00041
    Location:199 → 310
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00190
    Location:460 → 697
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. XM_019836146.2 → XP_019691705.2  mannan-binding lectin serine protease 2 isoform X2

    Related
    ENSFCTP00005059737.1, ENSFCTT00005088593.1
    Conserved Domains (4) summary
    cd00033
    Location:190 → 251
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00179
    Location:29 → 66
    EGF_CA; Calcium-binding EGF-like domain
    cd00041
    Location:74 → 185
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00190
    Location:335 → 572
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  3. XM_019836149.2 → XP_019691708.1  mannan-binding lectin serine protease 2 isoform X3

    Related
    ENSFCTP00005059725.1, ENSFCTT00005088573.1
    Conserved Domains (2) summary
    smart00042
    Location:43 → 149
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    smart00179
    Location:153 → 191
    EGF_CA; Calcium-binding EGF-like domain
Nucleotide Protein
Heading Accession and Version

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