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SPTAN1 spectrin alpha, non-erythrocytic 1 [ Felis catus (domestic cat) ]

Gene ID: 101080748, updated on 17-Aug-2024

Summary

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Official Symbol
SPTAN1
Official Full Name
spectrin alpha, non-erythrocytic 1
Primary source
VGNC:VGNC:65658
See related
EnsemblRapid:ENSFCTG00005030379
Gene type
protein coding
RefSeq status
MODEL
Organism
Felis catus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: D4
Exon count:
59
Annotation release Status Assembly Chr Location
105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) D4 NC_058380.1 (86968862..87030746)
104 previous assembly Felis_catus_9.0 (GCF_000181335.3) D4 NC_018735.3 (89164777..89226614)

Chromosome D4 - NC_058380.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC109493987 Neighboring gene 60S ribosomal protein L37a-like Neighboring gene GLE1 RNA export mediator Neighboring gene dynein 2 intermediate chain 2 Neighboring gene SET nuclear proto-oncogene Neighboring gene protein kinase N3 Neighboring gene zinc finger DHHC-type palmitoyltransferase 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cortical actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
spectrin alpha chain, non-erythrocytic 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference F.catus_Fca126_mat1.0 Primary Assembly

Genomic

  1. NC_058380.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

    Range
    86968862..87030746
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_019816634.3 → XP_019672193.2  spectrin alpha chain, non-erythrocytic 1 isoform X3

    UniProtKB/TrEMBL
    A0A2I2UU45
    Related
    ENSFCTP00005058057.1, ENSFCTT00005085025.1
    Conserved Domains (5) summary
    PTZ00184
    Location:2346 → 2495
    PTZ00184; calmodulin; Provisional
    smart00150
    Location:1666 → 1766
    SPEC; Spectrin repeats
    cd11808
    Location:971 → 1023
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2353 → 2421
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:679 → 890
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  2. XM_019816632.2 → XP_019672191.2  spectrin alpha chain, non-erythrocytic 1 isoform X1

    UniProtKB/TrEMBL
    A0A2I2V259
    Conserved Domains (5) summary
    PTZ00184
    Location:2358 → 2507
    PTZ00184; calmodulin; Provisional
    smart00150
    Location:1678 → 1778
    SPEC; Spectrin repeats
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2365 → 2433
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  3. XM_019816637.3 → XP_019672196.2  spectrin alpha chain, non-erythrocytic 1 isoform X6

    UniProtKB/TrEMBL
    A0A2I2U6D2
    Conserved Domains (5) summary
    PTZ00184
    Location:2337 → 2486
    PTZ00184; calmodulin; Provisional
    smart00150
    Location:1678 → 1778
    SPEC; Spectrin repeats
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2344 → 2412
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  4. XM_019816639.3 → XP_019672198.2  spectrin alpha chain, non-erythrocytic 1 isoform X8

    UniProtKB/TrEMBL
    A0A2I2U6D2
    Related
    ENSFCTP00005058019.1, ENSFCTT00005084934.1
    Conserved Domains (5) summary
    PTZ00184
    Location:2331 → 2480
    PTZ00184; calmodulin; Provisional
    smart00150
    Location:1678 → 1778
    SPEC; Spectrin repeats
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2338 → 2406
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  5. XM_019816633.2 → XP_019672192.2  spectrin alpha chain, non-erythrocytic 1 isoform X2

    UniProtKB/TrEMBL
    A0A2I2V259
    Conserved Domains (5) summary
    PTZ00184
    Location:2353 → 2502
    PTZ00184; calmodulin; Provisional
    smart00150
    Location:1673 → 1773
    SPEC; Spectrin repeats
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2360 → 2428
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  6. XM_019816638.3 → XP_019672197.2  spectrin alpha chain, non-erythrocytic 1 isoform X7

    UniProtKB/TrEMBL
    A0A2I2U6D2
    Related
    ENSFCTP00005058145.1, ENSFCTT00005085232.1
    Conserved Domains (5) summary
    PTZ00184
    Location:2332 → 2481
    PTZ00184; calmodulin; Provisional
    smart00150
    Location:1673 → 1773
    SPEC; Spectrin repeats
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2339 → 2407
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  7. XM_019816635.2 → XP_019672194.2  spectrin alpha chain, non-erythrocytic 1 isoform X4

    UniProtKB/TrEMBL
    A0A2I2V259
    Conserved Domains (5) summary
    PTZ00184
    Location:2342 → 2491
    PTZ00184; calmodulin; Provisional
    smart00150
    Location:1662 → 1762
    SPEC; Spectrin repeats
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2349 → 2417
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  8. XM_019816636.2 → XP_019672195.2  spectrin alpha chain, non-erythrocytic 1 isoform X5

    UniProtKB/TrEMBL
    A0A2I2V259
    Conserved Domains (5) summary
    PTZ00184
    Location:2338 → 2487
    PTZ00184; calmodulin; Provisional
    smart00150
    Location:1658 → 1758
    SPEC; Spectrin repeats
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2345 → 2413
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  9. XM_019816640.3 → XP_019672199.2  spectrin alpha chain, non-erythrocytic 1 isoform X9

    UniProtKB/TrEMBL
    A0A2I2U6D2
    Conserved Domains (5) summary
    PTZ00184
    Location:2317 → 2466
    PTZ00184; calmodulin; Provisional
    smart00150
    Location:1658 → 1758
    SPEC; Spectrin repeats
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2324 → 2392
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  10. XM_019816641.3 → XP_019672200.2  spectrin alpha chain, non-erythrocytic 1 isoform X10

    UniProtKB/TrEMBL
    A0A2I2U6D2
    Related
    ENSFCTP00005058102.1, ENSFCTT00005085131.1
    Conserved Domains (5) summary
    PTZ00184
    Location:2312 → 2461
    PTZ00184; calmodulin; Provisional
    smart00150
    Location:1653 → 1753
    SPEC; Spectrin repeats
    cd11808
    Location:983 → 1035
    SH3_Alpha_Spectrin; Src homology 3 domain of Alpha Spectrin
    cd00051
    Location:2319 → 2387
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:691 → 902
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
Nucleotide Protein
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