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RGS12 regulator of G protein signaling 12 [ Sarcophilus harrisii (Tasmanian devil) ]

Gene ID: 100930548, updated on 8-Mar-2024

Summary

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Gene symbol
RGS12
Gene description
regulator of G protein signaling 12
See related
Ensembl:ENSSHAG00000002156
Gene type
protein coding
RefSeq status
MODEL
Organism
Sarcophilus harrisii
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 6
Exon count:
19
Annotation release Status Assembly Chr Location
103 current mSarHar1.11 (GCF_902635505.1) 6 NC_045431.1 (185295924..185522257, complement)
102 previous assembly Devil_ref v7.0 (GCF_000189315.1) 6 Unlocalized Scaffold NW_003846883.1 (26472..230112, complement)

Chromosome 6 - NC_045431.1Genomic Context describing neighboring genes Neighboring gene docking protein 7 Neighboring gene HGF activator Neighboring gene Myb/SANT DNA binding domain containing 1 Neighboring gene huntingtin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
regulator of G-protein signaling 12

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Sarcophilus harrisii Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mSarHar1.11 Primary Assembly

Genomic

  1. NC_045431.1 Reference mSarHar1.11 Primary Assembly

    Range
    185295924..185522257 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_031943011.1 → XP_031798871.1  regulator of G-protein signaling 12 isoform X2

    UniProtKB/TrEMBL
    G3VGY1
    Conserved Domains (8) summary
    cd08742
    Location:712 → 826
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    smart00390
    Location:975 → 996
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    cd00992
    Location:20 → 96
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13162
    Location:230 → 361
    PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
    pfam16611
    Location:893 → 967
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16612
    Location:1025 → 1168
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16613
    Location:832 → 869
    RGS12_us1; Unstructured region of RGS12
    cl28922
    Location:866 → 891
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  2. XM_031943010.1 → XP_031798870.1  regulator of G-protein signaling 12 isoform X1

    UniProtKB/TrEMBL
    G3VGY1
    Related
    ENSSHAP00000002435.2, ENSSHAT00000002461.2
    Conserved Domains (9) summary
    cd08742
    Location:712 → 826
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    smart00390
    Location:1184 → 1205
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    cd00992
    Location:20 → 96
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13162
    Location:230 → 361
    PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
    cd17136
    Location:958 → 1027
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    cd17138
    Location:1028 → 1100
    RBD2_RGS12; Ras-binding domain (RBD) 2 of regulator of G protein signaling 12 (RGS12)
    pfam16611
    Location:1102 → 1176
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16612
    Location:1234 → 1377
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16613
    Location:832 → 945
    RGS12_us1; Unstructured region of RGS12

  3. XM_031943012.1 → XP_031798872.1  regulator of G-protein signaling 12 isoform X3

    UniProtKB/TrEMBL
    G3VGY0
    Related
    ENSSHAP00000002434.2, ENSSHAT00000002460.2
    Conserved Domains (7) summary
    cd08742
    Location:68 → 182
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    smart00390
    Location:540 → 561
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    cd17136
    Location:314 → 383
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    cd17138
    Location:384 → 456
    RBD2_RGS12; Ras-binding domain (RBD) 2 of regulator of G protein signaling 12 (RGS12)
    pfam16611
    Location:458 → 532
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16612
    Location:590 → 733
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16613
    Location:188 → 301
    RGS12_us1; Unstructured region of RGS12
Nucleotide Protein
Heading Accession and Version

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