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RGS12 regulator of G protein signaling 12 [ Homo sapiens (human) ]

Gene ID: 6002, updated on 12-Oct-2019

Summary

Official Symbol
RGS12provided by HGNC
Official Full Name
regulator of G protein signaling 12provided by HGNC
Primary source
HGNC:HGNC:9994
See related
Ensembl:ENSG00000159788 MIM:602512
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in skin (RPKM 3.7), brain (RPKM 3.2) and 24 other tissues See more
Orthologs

Genomic context

See RGS12 in Genome Data Viewer
Location:
4p16.3
Exon count:
24
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (3292978..3439913)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (3315874..3441640)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene huntingtin Neighboring gene Sharpr-MPRA regulatory region 10599 Neighboring gene Myb/SANT DNA binding domain containing 1 Neighboring gene X antigen family member 3 pseudogene Neighboring gene ribosomal protein L7a pseudogene 29 Neighboring gene uncharacterized LOC105374354 Neighboring gene HGF activator

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp761K1617, DKFZp761K1817

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
GTPase activity TAS
Traceable Author Statement
more info
 
GTPase regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
condensed nuclear chromosome TAS
Traceable Author Statement
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear matrix IEA
Inferred from Electronic Annotation
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
colocalizes_with synapse ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
regulator of G-protein signaling 12
Names
regulator of G-protein signalling 12

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029903.1 RefSeqGene

    Range
    5001..130767
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002926.3NP_002917.1  regulator of G-protein signaling 12 isoform 2

    See identical proteins and their annotated locations for NP_002917.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longest transcript. It differs in the 3' UTR and coding region, compared to variant 1. These differences result in an isoform (2) with a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AF030111, AL590235, AL645949
    Consensus CDS
    CCDS3367.1
    UniProtKB/Swiss-Prot
    O14924
    Related
    ENSP00000372238.3, ENST00000382788.7
    Conserved Domains (9) summary
    smart00455
    Location:10351104
    RBD; Raf-like Ras-binding domain
    cd01817
    Location:9631035
    RGS12_RBD; Ubiquitin domain of RGS12 and RGS14
    cd08742
    Location:716830
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    cd00992
    Location:2096
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13162
    Location:228359
    PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
    pfam02188
    Location:11881209
    GoLoco; GoLoco motif
    pfam16611
    Location:11061176
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16612
    Location:12541374
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16613
    Location:836933
    RGS12_us1; Unstructured region of RGS12
  2. NM_198227.2NP_937870.1  regulator of G-protein signaling 12 isoform 3

    See identical proteins and their annotated locations for NP_937870.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream ATG and an isoform (3) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AF030109, AF030112, BM984992, CB242608
    Consensus CDS
    CCDS3368.1
    UniProtKB/Swiss-Prot
    O14924
    Related
    ENSP00000342133.4, ENST00000338806.4
    Conserved Domains (7) summary
    smart00455
    Location:387456
    RBD; Raf-like Ras-binding domain
    cd01817
    Location:315387
    RGS12_RBD; Ubiquitin domain of RGS12 and RGS14
    cd08742
    Location:68182
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    pfam02188
    Location:540561
    GoLoco; GoLoco motif
    pfam16611
    Location:458528
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16612
    Location:606726
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16613
    Location:188285
    RGS12_us1; Unstructured region of RGS12
  3. NM_198229.2NP_937872.1  regulator of G-protein signaling 12 isoform 1

    See identical proteins and their annotated locations for NP_937872.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AF030111, AL590235, AL645949, BE048490
    Consensus CDS
    CCDS3366.1
    UniProtKB/Swiss-Prot
    O14924
    Related
    ENSP00000339381.5, ENST00000344733.9
    Conserved Domains (9) summary
    smart00455
    Location:10351104
    RBD; Raf-like Ras-binding domain
    cd01817
    Location:9631035
    RGS12_RBD; Ubiquitin domain of RGS12 and RGS14
    cd08742
    Location:716830
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    cd00992
    Location:2096
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13162
    Location:228359
    PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
    pfam02188
    Location:11881209
    GoLoco; GoLoco motif
    pfam16611
    Location:11061176
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16612
    Location:12541374
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16613
    Location:836933
    RGS12_us1; Unstructured region of RGS12

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    3292978..3439913
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006713905.1XP_006713968.1  regulator of G-protein signaling 12 isoform X1

    See identical proteins and their annotated locations for XP_006713968.1

    UniProtKB/Swiss-Prot
    O14924
    Related
    ENSP00000338509.4, ENST00000336727.7
    Conserved Domains (9) summary
    smart00455
    Location:10351104
    RBD; Raf-like Ras-binding domain
    cd01817
    Location:9631035
    RGS12_RBD; Ubiquitin domain of RGS12 and RGS14
    cd08742
    Location:716830
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    cd00992
    Location:2096
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13162
    Location:228359
    PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
    pfam02188
    Location:11881209
    GoLoco; GoLoco motif
    pfam16611
    Location:11061176
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16612
    Location:12541374
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16613
    Location:836933
    RGS12_us1; Unstructured region of RGS12
  2. XM_006713906.2XP_006713969.1  regulator of G-protein signaling 12 isoform X2

    UniProtKB/Swiss-Prot
    O14924
    Conserved Domains (7) summary
    smart00455
    Location:10351104
    RBD; Raf-like Ras-binding domain
    cd01817
    Location:9631035
    RGS12_RBD; Ubiquitin domain of RGS12 and RGS14
    cd08742
    Location:716830
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    cd00992
    Location:2096
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13162
    Location:228359
    PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
    pfam16611
    Location:11061137
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16613
    Location:836933
    RGS12_us1; Unstructured region of RGS12
  3. XM_017008530.1XP_016864019.1  regulator of G-protein signaling 12 isoform X3

  4. XM_011513543.2XP_011511845.1  regulator of G-protein signaling 12 isoform X4

    See identical proteins and their annotated locations for XP_011511845.1

    UniProtKB/Swiss-Prot
    O14924
    Conserved Domains (7) summary
    smart00455
    Location:234303
    RBD; Raf-like Ras-binding domain
    cd01817
    Location:162234
    RGS12_RBD; Ubiquitin domain of RGS12 and RGS14
    pfam02188
    Location:387408
    GoLoco; GoLoco motif
    pfam16611
    Location:305375
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16612
    Location:453573
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16613
    Location:35132
    RGS12_us1; Unstructured region of RGS12
    cl02565
    Location:129
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  5. XM_017008529.2XP_016864018.1  regulator of G-protein signaling 12 isoform X1

    UniProtKB/Swiss-Prot
    O14924
    Conserved Domains (9) summary
    smart00455
    Location:10351104
    RBD; Raf-like Ras-binding domain
    cd01817
    Location:9631035
    RGS12_RBD; Ubiquitin domain of RGS12 and RGS14
    cd08742
    Location:716830
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    cd00992
    Location:2096
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13162
    Location:228359
    PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
    pfam02188
    Location:11881209
    GoLoco; GoLoco motif
    pfam16611
    Location:11061176
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16612
    Location:12541374
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16613
    Location:836933
    RGS12_us1; Unstructured region of RGS12
  6. XM_017008531.2XP_016864020.1  regulator of G-protein signaling 12 isoform X4

    UniProtKB/Swiss-Prot
    O14924
    Conserved Domains (7) summary
    smart00455
    Location:234303
    RBD; Raf-like Ras-binding domain
    cd01817
    Location:162234
    RGS12_RBD; Ubiquitin domain of RGS12 and RGS14
    pfam02188
    Location:387408
    GoLoco; GoLoco motif
    pfam16611
    Location:305375
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16612
    Location:453573
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16613
    Location:35132
    RGS12_us1; Unstructured region of RGS12
    cl02565
    Location:129
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  7. XM_017008532.1XP_016864021.1  regulator of G-protein signaling 12 isoform X4

    UniProtKB/Swiss-Prot
    O14924
    Conserved Domains (7) summary
    smart00455
    Location:234303
    RBD; Raf-like Ras-binding domain
    cd01817
    Location:162234
    RGS12_RBD; Ubiquitin domain of RGS12 and RGS14
    pfam02188
    Location:387408
    GoLoco; GoLoco motif
    pfam16611
    Location:305375
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16612
    Location:453573
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16613
    Location:35132
    RGS12_us1; Unstructured region of RGS12
    cl02565
    Location:129
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  8. XM_017008534.1XP_016864023.1  regulator of G-protein signaling 12 isoform X5

  9. XM_006713907.1XP_006713970.1  regulator of G-protein signaling 12 isoform X4

    See identical proteins and their annotated locations for XP_006713970.1

    UniProtKB/Swiss-Prot
    O14924
    Conserved Domains (7) summary
    smart00455
    Location:234303
    RBD; Raf-like Ras-binding domain
    cd01817
    Location:162234
    RGS12_RBD; Ubiquitin domain of RGS12 and RGS14
    pfam02188
    Location:387408
    GoLoco; GoLoco motif
    pfam16611
    Location:305375
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16612
    Location:453573
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16613
    Location:35132
    RGS12_us1; Unstructured region of RGS12
    cl02565
    Location:129
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  10. XM_017008533.1XP_016864022.1  regulator of G-protein signaling 12 isoform X4

    UniProtKB/Swiss-Prot
    O14924
    Conserved Domains (7) summary
    smart00455
    Location:234303
    RBD; Raf-like Ras-binding domain
    cd01817
    Location:162234
    RGS12_RBD; Ubiquitin domain of RGS12 and RGS14
    pfam02188
    Location:387408
    GoLoco; GoLoco motif
    pfam16611
    Location:305375
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16612
    Location:453573
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16613
    Location:35132
    RGS12_us1; Unstructured region of RGS12
    cl02565
    Location:129
    RGS; Regulator of G protein signaling (RGS) domain superfamily

RNA

  1. XR_002959745.1 RNA Sequence

  2. XR_427479.2 RNA Sequence

  3. XR_924987.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_198230.1: Suppressed sequence

    Description
    NM_198230.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_198430.1: Suppressed sequence

    Description
    NM_198430.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  3. NM_198432.1: Suppressed sequence

    Description
    NM_198432.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  4. NM_198587.1: Suppressed sequence

    Description
    NM_198587.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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