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RGS12 regulator of G protein signaling 12 [ Homo sapiens (human) ]

Gene ID: 6002, updated on 4-Sep-2021

Summary

Official Symbol
RGS12provided by HGNC
Official Full Name
regulator of G protein signaling 12provided by HGNC
Primary source
HGNC:HGNC:9994
See related
Ensembl:ENSG00000159788 MIM:602512
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in skin (RPKM 3.7), brain (RPKM 3.2) and 24 other tissues See more
Orthologs
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Genomic context

See RGS12 in Genome Data Viewer
Location:
4p16.3
Exon count:
26
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (3285891..3439913)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (3315874..3441640)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene huntingtin Neighboring gene Sharpr-MPRA regulatory region 10599 Neighboring gene Myb/SANT DNA binding domain containing 1 Neighboring gene X antigen family member 3 pseudogene Neighboring gene ribosomal protein L7a pseudogene 29 Neighboring gene uncharacterized LOC105374354 Neighboring gene HGF activator

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp761K1617, DKFZp761K1817

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity TAS
Traceable Author Statement
more info
 
enables GTPase regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in condensed nuclear chromosome TAS
Traceable Author Statement
more info
PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nuclear matrix IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
colocalizes_with synapse ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
regulator of G-protein signaling 12
Names
regulator of G-protein signalling 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029903.1 RefSeqGene

    Range
    5001..130767
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001394154.1NP_001381083.1  regulator of G-protein signaling 12 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL590235, AL645949
    Conserved Domains (9) summary
    cd08742
    Location:716830
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    smart00390
    Location:11881209
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    cd00992
    Location:2096
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13162
    Location:228359
    PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
    cd17136
    Location:9621031
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    pfam16611
    Location:11061180
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16612
    Location:12391376
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16613
    Location:836949
    RGS12_us1; Unstructured region of RGS12
    cl28922
    Location:10321104
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  2. NM_001394155.1NP_001381084.1  regulator of G-protein signaling 12 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL590235, AL645949
    Conserved Domains (9) summary
    cd08742
    Location:716830
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    smart00390
    Location:11881209
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    cd00992
    Location:2096
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13162
    Location:228359
    PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
    cd17136
    Location:9621031
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    pfam16611
    Location:11061180
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16612
    Location:12391376
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16613
    Location:836949
    RGS12_us1; Unstructured region of RGS12
    cl28922
    Location:10321104
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  3. NM_001394156.1NP_001381085.1  regulator of G-protein signaling 12 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL590235, AL645949
    Conserved Domains (9) summary
    cd08742
    Location:716830
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    smart00390
    Location:11881209
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    cd00992
    Location:2096
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13162
    Location:228359
    PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
    cd17136
    Location:9621031
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    pfam16611
    Location:11061180
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16612
    Location:12391376
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16613
    Location:836949
    RGS12_us1; Unstructured region of RGS12
    cl28922
    Location:10321104
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  4. NM_001394157.1NP_001381086.1  regulator of G-protein signaling 12 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL590235, AL645949
    Conserved Domains (5) summary
    cd08742
    Location:716830
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    cd00992
    Location:2096
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13162
    Location:228359
    PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
    cd17136
    Location:9621031
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    cl28922
    Location:10321104
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  5. NM_001394158.1NP_001381087.1  regulator of G-protein signaling 12 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL590235, AL645949
    Conserved Domains (7) summary
    cd08742
    Location:716830
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    cd00992
    Location:2096
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13162
    Location:228359
    PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
    cd17136
    Location:9621031
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    pfam16611
    Location:11061137
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16613
    Location:836949
    RGS12_us1; Unstructured region of RGS12
    cl28922
    Location:10321104
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  6. NM_001394159.1NP_001381088.1  regulator of G-protein signaling 12 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL645949
  7. NM_001394161.1NP_001381090.1  regulator of G-protein signaling 12 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL590235, AL645949
    Conserved Domains (7) summary
    smart00390
    Location:387408
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    cd17136
    Location:161230
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    pfam16611
    Location:305379
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16612
    Location:438575
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16613
    Location:35148
    RGS12_us1; Unstructured region of RGS12
    cl02565
    Location:129
    RGS; Regulator of G protein signaling (RGS) domain superfamily
    cl28922
    Location:231303
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  8. NM_001394162.1NP_001381091.1  regulator of G-protein signaling 12 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL590235, AL645949
    Conserved Domains (7) summary
    smart00390
    Location:387408
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    cd17136
    Location:161230
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    pfam16611
    Location:305379
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16612
    Location:438575
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16613
    Location:35148
    RGS12_us1; Unstructured region of RGS12
    cl02565
    Location:129
    RGS; Regulator of G protein signaling (RGS) domain superfamily
    cl28922
    Location:231303
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  9. NM_001394163.1NP_001381092.1  regulator of G-protein signaling 12 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL590235, AL645949
    Conserved Domains (7) summary
    smart00390
    Location:387408
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    cd17136
    Location:161230
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    pfam16611
    Location:305379
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16612
    Location:438575
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16613
    Location:35148
    RGS12_us1; Unstructured region of RGS12
    cl02565
    Location:129
    RGS; Regulator of G protein signaling (RGS) domain superfamily
    cl28922
    Location:231303
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  10. NM_002926.5NP_002917.1  regulator of G-protein signaling 12 isoform 2

    See identical proteins and their annotated locations for NP_002917.1

    Status: REVIEWED

    Source sequence(s)
    AL590235, AL645949
    Consensus CDS
    CCDS3367.1
    UniProtKB/Swiss-Prot
    O14924
    Related
    ENSP00000372238.3, ENST00000382788.7
    Conserved Domains (9) summary
    cd08742
    Location:716830
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    smart00390
    Location:11881209
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    cd00992
    Location:2096
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13162
    Location:228359
    PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
    cd17136
    Location:9621031
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    pfam16611
    Location:11061180
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16612
    Location:12391376
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16613
    Location:836949
    RGS12_us1; Unstructured region of RGS12
    cl28922
    Location:10321104
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  11. NM_198227.2NP_937870.1  regulator of G-protein signaling 12 isoform 3

    See identical proteins and their annotated locations for NP_937870.1

    Status: REVIEWED

    Source sequence(s)
    AF030109, AF030112, BM984992, CB242608
    Consensus CDS
    CCDS3368.1
    UniProtKB/Swiss-Prot
    O14924
    Related
    ENSP00000342133.4, ENST00000338806.4
    Conserved Domains (7) summary
    smart00455
    Location:387456
    RBD; Raf-like Ras-binding domain
    cd01817
    Location:315387
    RGS12_RBD; Ubiquitin domain of RGS12 and RGS14
    cd08742
    Location:68182
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    pfam02188
    Location:540561
    GoLoco; GoLoco motif
    pfam16611
    Location:458528
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16612
    Location:606726
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16613
    Location:188285
    RGS12_us1; Unstructured region of RGS12
  12. NM_198229.3NP_937872.1  regulator of G-protein signaling 12 isoform 1

    See identical proteins and their annotated locations for NP_937872.1

    Status: REVIEWED

    Source sequence(s)
    AL590235, AL645949
    Consensus CDS
    CCDS3366.1
    UniProtKB/Swiss-Prot
    O14924
    Related
    ENSP00000339381.5, ENST00000344733.9
    Conserved Domains (9) summary
    cd08742
    Location:716830
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    smart00390
    Location:11881209
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    cd00992
    Location:2096
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13162
    Location:228359
    PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
    cd17136
    Location:9621031
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    pfam16611
    Location:11061180
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16612
    Location:12391376
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16613
    Location:836949
    RGS12_us1; Unstructured region of RGS12
    cl28922
    Location:10321104
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    3285891..3439913
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513543.2XP_011511845.1  regulator of G-protein signaling 12 isoform X4

    See identical proteins and their annotated locations for XP_011511845.1

    UniProtKB/Swiss-Prot
    O14924
    Conserved Domains (7) summary
    smart00390
    Location:387408
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    cd17136
    Location:161230
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    pfam16611
    Location:305379
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16612
    Location:438575
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16613
    Location:35148
    RGS12_us1; Unstructured region of RGS12
    cl02565
    Location:129
    RGS; Regulator of G protein signaling (RGS) domain superfamily
    cl28922
    Location:231303
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  2. XM_017008529.2XP_016864018.1  regulator of G-protein signaling 12 isoform X1

    UniProtKB/Swiss-Prot
    O14924
    Conserved Domains (9) summary
    cd08742
    Location:716830
    RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
    smart00390
    Location:11881209
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    cd00992
    Location:2096
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13162
    Location:228359
    PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
    cd17136
    Location:9621031
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    pfam16611
    Location:11061180
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16612
    Location:12391376
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16613
    Location:836949
    RGS12_us1; Unstructured region of RGS12
    cl28922
    Location:10321104
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  3. XM_017008531.2XP_016864020.1  regulator of G-protein signaling 12 isoform X4

    UniProtKB/Swiss-Prot
    O14924
    Conserved Domains (7) summary
    smart00390
    Location:387408
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    cd17136
    Location:161230
    RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
    pfam16611
    Location:305379
    RGS12_us2; Unstructured region between RBD and GoLoco
    pfam16612
    Location:438575
    RGS12_usC; C-terminal unstructured region of RGS12
    pfam16613
    Location:35148
    RGS12_us1; Unstructured region of RGS12
    cl02565
    Location:129
    RGS; Regulator of G protein signaling (RGS) domain superfamily
    cl28922
    Location:231303
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  4. XM_017008534.1XP_016864023.1  regulator of G-protein signaling 12 isoform X5

RNA

  1. XR_002959745.1 RNA Sequence

  2. XR_427479.2 RNA Sequence

  3. XR_924987.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_198230.1: Suppressed sequence

    Description
    NM_198230.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_198430.1: Suppressed sequence

    Description
    NM_198430.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  3. NM_198432.1: Suppressed sequence

    Description
    NM_198432.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  4. NM_198587.1: Suppressed sequence

    Description
    NM_198587.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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