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NGLY1 N-glycanase 1 [ Canis lupus familiaris (dog) ]

Gene ID: 100682555, updated on 8-Mar-2024

Summary

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Official Symbol
NGLY1provided by VGNC
Official Full Name
N-glycanase 1provided by VGNC
Primary source
VGNC:VGNC:43796
See related
Ensembl:ENSCAFG00845026707
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 23
Exon count:
14
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 23 NC_051827.1 (18347625..18405157)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 23 NC_006605.4 (18042146..18099607)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 23 NC_049244.1 (18383003..18440512)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 23 NC_049283.1 (18166197..18223888)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 23 NC_049764.1 (18269312..18326783)

Chromosome 23 - NC_051827.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102156347 Neighboring gene ribosomal protein L31 pseudogene Neighboring gene 3-oxoacyl-ACP synthase, mitochondrial Neighboring gene DNA topoisomerase II beta Neighboring gene retinoic acid receptor beta Neighboring gene uncharacterized LOC111091903

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in glycoprotein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein deglycosylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein quality control for misfolded or incompletely synthesized proteins IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
XP_003639867.2
XP_038288056.1
XP_038288057.1
XP_038288058.1
XP_038288059.1
XP_038313052.1
XP_038313053.1
XP_038313054.1
XP_038363359.1
XP_038363360.1
XP_038363361.1
XP_038363362.1
XP_038363363.1
XP_038426603.1
XP_038426604.1
XP_038426605.1
XP_038426606.1
XP_038490784.1
XP_038490785.1
XP_038490786.1
XP_038490787.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051827.1 Reference ROS_Cfam_1.0

    Range
    18347625..18405157
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038432128.1 → XP_038288056.1  peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform X1

    UniProtKB/TrEMBL
    A0A8C0R7E2, A0A8C0TIN5
    Related
    ENSCAFP00845037076.1, ENSCAFT00845047241.1
    Conserved Domains (4) summary
    cd10459
    Location:19 → 109
    PUB_PNGase; PNGase/UBA or UBX (PUB) domain of the P97 adaptor protein Peptide:N-glycanase (PNGase)
    pfam01841
    Location:259 → 355
    Transglut_core; Transglutaminase-like superfamily
    pfam04721
    Location:458 → 652
    PAW; PNGase C-terminal domain, mannose-binding module PAW
    cl10615
    Location:339 → 393
    sm_acid_XPC-like; small acidic domain of Xeroderma pigmentosum group C complementing protein and similar proteins

  2. XM_038432131.1 → XP_038288059.1  peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform X3

    UniProtKB/TrEMBL
    A0A8C0R7E2, A0A8C0TFZ9, A0A8I3Q049
    Related
    ENSCAFP00845037270.1, ENSCAFT00845047501.1
    Conserved Domains (4) summary
    cd10459
    Location:19 → 109
    PUB_PNGase; PNGase/UBA or UBX (PUB) domain of the P97 adaptor protein Peptide:N-glycanase (PNGase)
    pfam01841
    Location:259 → 355
    Transglut_core; Transglutaminase-like superfamily
    cl10509
    Location:458 → 541
    PAW; PNGase C-terminal domain, mannose-binding module PAW
    cl10615
    Location:339 → 393
    sm_acid_XPC-like; small acidic domain of Xeroderma pigmentosum group C complementing protein and similar proteins

  3. XM_038432129.1 → XP_038288057.1  peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform X2

    UniProtKB/TrEMBL
    A0A8I3PQI1
    Conserved Domains (4) summary
    pfam01841
    Location:182 → 278
    Transglut_core; Transglutaminase-like superfamily
    pfam04721
    Location:381 → 575
    PAW; PNGase C-terminal domain, mannose-binding module PAW
    cl10615
    Location:262 → 316
    sm_acid_XPC-like; small acidic domain of Xeroderma pigmentosum group C complementing protein and similar proteins
    cl15262
    Location:1 → 32
    PUB; PNGase/UBA or UBX (PUB) domain of p97 adaptor proteins

  4. XM_038432130.1 → XP_038288058.1  peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform X2

    UniProtKB/TrEMBL
    A0A8I3PQI1
    Related
    ENSCAFP00845037015.1, ENSCAFT00845047168.1
    Conserved Domains (4) summary
    pfam01841
    Location:182 → 278
    Transglut_core; Transglutaminase-like superfamily
    pfam04721
    Location:381 → 575
    PAW; PNGase C-terminal domain, mannose-binding module PAW
    cl10615
    Location:262 → 316
    sm_acid_XPC-like; small acidic domain of Xeroderma pigmentosum group C complementing protein and similar proteins
    cl15262
    Location:1 → 32
    PUB; PNGase/UBA or UBX (PUB) domain of p97 adaptor proteins

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049283.1 Alternate UMICH_Zoey_3.1

    Range
    18166197..18223888
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038507431.1 → XP_038363359.1  peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform X1

    Conserved Domains (4) summary
    cd10459
    Location:19 → 109
    PUB_PNGase; PNGase/UBA or UBX (PUB) domain of the P97 adaptor protein Peptide:N-glycanase (PNGase)
    pfam01841
    Location:259 → 355
    Transglut_core; Transglutaminase-like superfamily
    pfam04721
    Location:458 → 652
    PAW; PNGase C-terminal domain, mannose-binding module PAW
    cl10615
    Location:339 → 393
    sm_acid_XPC-like; small acidic domain of Xeroderma pigmentosum group C complementing protein and similar proteins

  2. XM_038507435.1 → XP_038363363.1  peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform X3

    Conserved Domains (4) summary
    cd10459
    Location:19 → 109
    PUB_PNGase; PNGase/UBA or UBX (PUB) domain of the P97 adaptor protein Peptide:N-glycanase (PNGase)
    pfam01841
    Location:259 → 355
    Transglut_core; Transglutaminase-like superfamily
    cl10509
    Location:458 → 541
    PAW; PNGase C-terminal domain, mannose-binding module PAW
    cl10615
    Location:339 → 393
    sm_acid_XPC-like; small acidic domain of Xeroderma pigmentosum group C complementing protein and similar proteins

  3. XM_038507433.1 → XP_038363361.1  peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform X2

    Conserved Domains (4) summary
    pfam01841
    Location:182 → 278
    Transglut_core; Transglutaminase-like superfamily
    pfam04721
    Location:381 → 575
    PAW; PNGase C-terminal domain, mannose-binding module PAW
    cl10615
    Location:262 → 316
    sm_acid_XPC-like; small acidic domain of Xeroderma pigmentosum group C complementing protein and similar proteins
    cl15262
    Location:1 → 32
    PUB; PNGase/UBA or UBX (PUB) domain of p97 adaptor proteins

  4. XM_038507434.1 → XP_038363362.1  peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform X2

    Conserved Domains (4) summary
    pfam01841
    Location:182 → 278
    Transglut_core; Transglutaminase-like superfamily
    pfam04721
    Location:381 → 575
    PAW; PNGase C-terminal domain, mannose-binding module PAW
    cl10615
    Location:262 → 316
    sm_acid_XPC-like; small acidic domain of Xeroderma pigmentosum group C complementing protein and similar proteins
    cl15262
    Location:1 → 32
    PUB; PNGase/UBA or UBX (PUB) domain of p97 adaptor proteins

  5. XM_038507432.1 → XP_038363360.1  peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform X4

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049764.1 Alternate UNSW_CanFamBas_1.0

    Range
    18269312..18326783
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038634856.1 → XP_038490784.1  peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform X1

    Conserved Domains (4) summary
    cd10459
    Location:19 → 109
    PUB_PNGase; PNGase/UBA or UBX (PUB) domain of the P97 adaptor protein Peptide:N-glycanase (PNGase)
    pfam01841
    Location:259 → 355
    Transglut_core; Transglutaminase-like superfamily
    pfam04721
    Location:458 → 652
    PAW; PNGase C-terminal domain, mannose-binding module PAW
    cl10615
    Location:339 → 393
    sm_acid_XPC-like; small acidic domain of Xeroderma pigmentosum group C complementing protein and similar proteins

  2. XM_038634859.1 → XP_038490787.1  peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform X3

    Conserved Domains (4) summary
    cd10459
    Location:19 → 109
    PUB_PNGase; PNGase/UBA or UBX (PUB) domain of the P97 adaptor protein Peptide:N-glycanase (PNGase)
    pfam01841
    Location:259 → 355
    Transglut_core; Transglutaminase-like superfamily
    cl10509
    Location:458 → 541
    PAW; PNGase C-terminal domain, mannose-binding module PAW
    cl10615
    Location:339 → 393
    sm_acid_XPC-like; small acidic domain of Xeroderma pigmentosum group C complementing protein and similar proteins

  3. XM_038634857.1 → XP_038490785.1  peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform X2

    Conserved Domains (4) summary
    pfam01841
    Location:182 → 278
    Transglut_core; Transglutaminase-like superfamily
    pfam04721
    Location:381 → 575
    PAW; PNGase C-terminal domain, mannose-binding module PAW
    cl10615
    Location:262 → 316
    sm_acid_XPC-like; small acidic domain of Xeroderma pigmentosum group C complementing protein and similar proteins
    cl15262
    Location:1 → 32
    PUB; PNGase/UBA or UBX (PUB) domain of p97 adaptor proteins

  4. XM_038634858.1 → XP_038490786.1  peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform X2

    Conserved Domains (4) summary
    pfam01841
    Location:182 → 278
    Transglut_core; Transglutaminase-like superfamily
    pfam04721
    Location:381 → 575
    PAW; PNGase C-terminal domain, mannose-binding module PAW
    cl10615
    Location:262 → 316
    sm_acid_XPC-like; small acidic domain of Xeroderma pigmentosum group C complementing protein and similar proteins
    cl15262
    Location:1 → 32
    PUB; PNGase/UBA or UBX (PUB) domain of p97 adaptor proteins

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049244.1 Alternate UU_Cfam_GSD_1.0

    Range
    18383003..18440512
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038570675.1 → XP_038426603.1  peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform X1

    UniProtKB/TrEMBL
    A0A8C0R7E2, A0A8C0TIN5
    Conserved Domains (4) summary
    cd10459
    Location:19 → 109
    PUB_PNGase; PNGase/UBA or UBX (PUB) domain of the P97 adaptor protein Peptide:N-glycanase (PNGase)
    pfam01841
    Location:259 → 355
    Transglut_core; Transglutaminase-like superfamily
    pfam04721
    Location:458 → 652
    PAW; PNGase C-terminal domain, mannose-binding module PAW
    cl10615
    Location:339 → 393
    sm_acid_XPC-like; small acidic domain of Xeroderma pigmentosum group C complementing protein and similar proteins

  2. XM_038570678.1 → XP_038426606.1  peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform X3

    UniProtKB/TrEMBL
    A0A8C0R7E2, A0A8C0TFZ9, A0A8I3Q049
    Conserved Domains (4) summary
    cd10459
    Location:19 → 109
    PUB_PNGase; PNGase/UBA or UBX (PUB) domain of the P97 adaptor protein Peptide:N-glycanase (PNGase)
    pfam01841
    Location:259 → 355
    Transglut_core; Transglutaminase-like superfamily
    cl10509
    Location:458 → 541
    PAW; PNGase C-terminal domain, mannose-binding module PAW
    cl10615
    Location:339 → 393
    sm_acid_XPC-like; small acidic domain of Xeroderma pigmentosum group C complementing protein and similar proteins

  3. XM_038570676.1 → XP_038426604.1  peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform X2

    UniProtKB/TrEMBL
    A0A8I3PQI1
    Conserved Domains (4) summary
    pfam01841
    Location:182 → 278
    Transglut_core; Transglutaminase-like superfamily
    pfam04721
    Location:381 → 575
    PAW; PNGase C-terminal domain, mannose-binding module PAW
    cl10615
    Location:262 → 316
    sm_acid_XPC-like; small acidic domain of Xeroderma pigmentosum group C complementing protein and similar proteins
    cl15262
    Location:1 → 32
    PUB; PNGase/UBA or UBX (PUB) domain of p97 adaptor proteins

  4. XM_038570677.1 → XP_038426605.1  peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform X2

    UniProtKB/TrEMBL
    A0A8I3PQI1
    Conserved Domains (4) summary
    pfam01841
    Location:182 → 278
    Transglut_core; Transglutaminase-like superfamily
    pfam04721
    Location:381 → 575
    PAW; PNGase C-terminal domain, mannose-binding module PAW
    cl10615
    Location:262 → 316
    sm_acid_XPC-like; small acidic domain of Xeroderma pigmentosum group C complementing protein and similar proteins
    cl15262
    Location:1 → 32
    PUB; PNGase/UBA or UBX (PUB) domain of p97 adaptor proteins

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006605.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    18042146..18099607
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003639819.5 → XP_003639867.2  peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform X1

    UniProtKB/TrEMBL
    A0A8C0R7E2, A0A8C0TIN5
    Conserved Domains (4) summary
    cd10459
    Location:19 → 109
    PUB_PNGase; PNGase/UBA or UBX (PUB) domain of the P97 adaptor protein Peptide:N-glycanase (PNGase)
    pfam01841
    Location:259 → 355
    Transglut_core; Transglutaminase-like superfamily
    pfam04721
    Location:458 → 652
    PAW; PNGase C-terminal domain, mannose-binding module PAW
    cl10615
    Location:339 → 393
    sm_acid_XPC-like; small acidic domain of Xeroderma pigmentosum group C complementing protein and similar proteins

  2. XM_038457126.1 → XP_038313054.1  peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform X3

    UniProtKB/TrEMBL
    A0A8C0R7E2, A0A8C0TFZ9, A0A8I3Q049
    Conserved Domains (4) summary
    cd10459
    Location:19 → 109
    PUB_PNGase; PNGase/UBA or UBX (PUB) domain of the P97 adaptor protein Peptide:N-glycanase (PNGase)
    pfam01841
    Location:259 → 355
    Transglut_core; Transglutaminase-like superfamily
    cl10509
    Location:458 → 541
    PAW; PNGase C-terminal domain, mannose-binding module PAW
    cl10615
    Location:339 → 393
    sm_acid_XPC-like; small acidic domain of Xeroderma pigmentosum group C complementing protein and similar proteins

  3. XM_038457124.1 → XP_038313052.1  peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform X2

    UniProtKB/TrEMBL
    A0A8I3PQI1
    Conserved Domains (4) summary
    pfam01841
    Location:182 → 278
    Transglut_core; Transglutaminase-like superfamily
    pfam04721
    Location:381 → 575
    PAW; PNGase C-terminal domain, mannose-binding module PAW
    cl10615
    Location:262 → 316
    sm_acid_XPC-like; small acidic domain of Xeroderma pigmentosum group C complementing protein and similar proteins
    cl15262
    Location:1 → 32
    PUB; PNGase/UBA or UBX (PUB) domain of p97 adaptor proteins

  4. XM_038457125.1 → XP_038313053.1  peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform X2

    UniProtKB/TrEMBL
    A0A8I3PQI1
    Conserved Domains (4) summary
    pfam01841
    Location:182 → 278
    Transglut_core; Transglutaminase-like superfamily
    pfam04721
    Location:381 → 575
    PAW; PNGase C-terminal domain, mannose-binding module PAW
    cl10615
    Location:262 → 316
    sm_acid_XPC-like; small acidic domain of Xeroderma pigmentosum group C complementing protein and similar proteins
    cl15262
    Location:1 → 32
    PUB; PNGase/UBA or UBX (PUB) domain of p97 adaptor proteins
Nucleotide Protein
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