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Ngly1 N-glycanase 1 [ Mus musculus (house mouse) ]

Gene ID: 59007, updated on 4-Dec-2022

Summary

Official Symbol
Ngly1provided by MGI
Official Full Name
N-glycanase 1provided by MGI
Primary source
MGI:MGI:1913276
See related
Ensembl:ENSMUSG00000021785 AllianceGenome:MGI:1913276
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Png1; PNGase; 1110002C09Rik
Summary
Predicted to enable peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity. Involved in glycoprotein catabolic process. Located in cytoplasm. Is expressed in axial musculature; nervous system; thymus primordium; and vibrissa. Human ortholog(s) of this gene implicated in NGLY1-deficiency. Orthologous to human NGLY1 (N-glycanase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 30.1), adrenal adult (RPKM 10.0) and 28 other tissues See more
Orthologs
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Genomic context

See Ngly1 in Genome Data Viewer
Location:
14 A1; 14 7.08 cM
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (6157837..6220449, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (16249314..16311926)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene retinoic acid receptor, beta Neighboring gene predicted gene, 53820 Neighboring gene predicted gene, 46442 Neighboring gene topoisomerase (DNA) II beta Neighboring gene ribosomal protein L31, pseudogene 3 Neighboring gene 3-oxoacyl-ACP synthase, mitochondrial Neighboring gene ribosomal protein L4 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity ISO
Inferred from Sequence Orthology
more info
 
enables peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in ER-associated misfolded protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in glycoprotein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glycoprotein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glycoprotein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein deglycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein deglycosylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein quality control for misfolded or incompletely synthesized proteins IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
Names
peptide N-glycanase homolog
NP_001349361.1
NP_001349362.1
NP_067479.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362432.1NP_001349361.1  peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC173482, AK148931, BC028961
    Conserved Domains (4) summary
    pfam03835
    Location:316400
    Rad4; Rad4 transglutaminase-like domain
    pfam01841
    Location:253332
    Transglut_core; Transglutaminase-like superfamily
    pfam04721
    Location:435629
    PAW; PNGase C-terminal domain, mannose-binding module PAW
    cl15262
    Location:2690
    PUB; PNGase/UBA or UBX (PUB) domain of p97 adaptor proteins
  2. NM_001362433.1NP_001349362.1  peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC173482, AK028248, AK169205, BC028961
    Consensus CDS
    CCDS88581.1
    UniProtKB/TrEMBL
    A0A286YCI0
    Related
    ENSMUSP00000152998.2, ENSMUST00000224656.2
    Conserved Domains (4) summary
    cd10459
    Location:19109
    PUB_PNGase; PNGase/UBA or UBX (PUB) domain of the P97 adaptor protein Peptide:N-glycanase (PNGase)
    pfam03835
    Location:335420
    Rad4; Rad4 transglutaminase-like domain
    pfam01841
    Location:272351
    Transglut_core; Transglutaminase-like superfamily
    pfam04721
    Location:413593
    PAW; PNGase C-terminal domain, mannose-binding module PAW
  3. NM_021504.3NP_067479.2  peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform 1

    See identical proteins and their annotated locations for NP_067479.2

    Status: VALIDATED

    Source sequence(s)
    AK028248
    Consensus CDS
    CCDS26832.1
    UniProtKB/Swiss-Prot
    Q9CTK3, Q9JI78
    Related
    ENSMUSP00000022310.7, ENSMUST00000022310.7
    Conserved Domains (5) summary
    cd10459
    Location:19109
    PUB_PNGase; PNGase/UBA or UBX (PUB) domain of the P97 adaptor protein Peptide:N-glycanase (PNGase)
    COG1305
    Location:290351
    YebA; Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones]
    pfam01841
    Location:272351
    Transglut_core; Transglutaminase-like superfamily
    pfam03835
    Location:335419
    Rad4; Rad4 transglutaminase-like domain
    pfam04721
    Location:454648
    PAW; PNGase C-terminal domain, mannose-binding module PAW

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    6157837..6220449 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)