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PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 [ Loxodonta africana (African savanna elephant) ]

Gene ID: 100653731, updated on 11-Apr-2024

Summary

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Gene symbol
PIK3R1
Gene description
phosphoinositide-3-kinase regulatory subunit 1
See related
EnsemblRapid:ENSLAFG00000018267
Gene type
protein coding
RefSeq status
MODEL
Organism
Loxodonta africana
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_04 current mLoxAfr1.hap2 (GCF_030014295.1) 2 NC_087343.1 (73250847..73348318)
102 previous assembly Loxafr3.0 (GCF_000001905.1) Unplaced Scaffold NW_003573427.1 (71876413..71976566)

Chromosome 2 - NC_087343.1Genomic Context describing neighboring genes Neighboring gene B-cell CLL/lymphoma 9 protein-like Neighboring gene small ribosomal subunit protein uS11-like Neighboring gene uncharacterized LOC135228250 Neighboring gene uncharacterized LOC135228251 Neighboring gene large ribosomal subunit protein eL33-like Neighboring gene solute carrier family 30 member 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of phosphatidylinositol 3-kinase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol 3-kinase regulatory subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_030014295.1-RS_2024_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mLoxAfr1.hap2

Genomic

  1. NC_087343.1 Reference mLoxAfr1.hap2

    Range
    73250847..73348318
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003408071.4 → XP_003408119.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1

    See identical proteins and their annotated locations for XP_003408119.1

    UniProtKB/TrEMBL
    G3TKF7
    Related
    ENSLAFP00000015303.5, ENSLAFT00000018268.5
    Conserved Domains (6) summary
    cd09930
    Location:617 → 720
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:325 → 435
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11910
    Location:5 → 79
    SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12924
    Location:440 → 600
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    cd04388
    Location:114 → 302
    RhoGAP_p85; RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region ...
    pfam16454
    Location:439 → 598
    PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain

  2. XM_010588191.3 → XP_010586493.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1

    See identical proteins and their annotated locations for XP_010586493.1

    UniProtKB/TrEMBL
    G3TKF7
    Conserved Domains (6) summary
    cd09930
    Location:617 → 720
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:325 → 435
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd11910
    Location:5 → 79
    SH3_PI3K_p85alpha; Src Homology 3 domain of the p85alpha regulatory subunit of Class IA Phosphatidylinositol 3-kinases
    cd12924
    Location:440 → 600
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    cd04388
    Location:114 → 302
    RhoGAP_p85; RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region ...
    pfam16454
    Location:439 → 598
    PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain

  3. XM_064272766.1 → XP_064128836.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2

  4. XM_064272768.1 → XP_064128838.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3

    Related
    ENSLAFP00000041131.1, ENSLAFT00000058352.1

  5. XM_003408072.4 → XP_003408120.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X4

    Related
    ENSLAFP00000031815.1, ENSLAFT00000052157.1
    Conserved Domains (4) summary
    cd09930
    Location:347 → 450
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:55 → 165
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd12924
    Location:170 → 330
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    pfam16454
    Location:169 → 328
    PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
Nucleotide Protein
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