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pik3r1 phosphoinositide-3-kinase regulatory subunit 1 [ Anolis carolinensis (green anole) ]

Gene ID: 100556883, updated on 3-Apr-2024

Summary

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Gene symbol
pik3r1
Gene description
phosphoinositide-3-kinase regulatory subunit 1
See related
Ensembl:ENSACAG00000016290
Gene type
protein coding
RefSeq status
MODEL
Organism
Anolis carolinensis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Iguania; Dactyloidae; Anolis
Orthologs
human mouse all
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Genomic context

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See pik3r1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current rAnoCar3.1.pri (GCF_035594765.1) 2 NC_085842.1 (290924584..290993251, complement)
102 previous assembly AnoCar2.0 (GCF_000090745.1) 2 NC_014777.1 (11912721..11972362)

Chromosome 2 - NC_085842.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 30 member 5 Neighboring gene U1 spliceosomal RNA Neighboring gene U2 spliceosomal RNA Neighboring gene CD180 molecule

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of phosphatidylinositol 3-kinase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol 3-kinase regulatory subunit alpha
Names
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_035594765.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference rAnoCar3.1.pri

Genomic

  1. NC_085842.1 Reference rAnoCar3.1.pri

    Range
    290924584..290993251 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_062972361.1 → XP_062828431.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1

    UniProtKB/TrEMBL
    G1KSH1

  2. XM_008102904.3 → XP_008101111.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2

    UniProtKB/TrEMBL
    R4GAH3
    Related
    ENSACAP00000022271.1
    Conserved Domains (5) summary
    cd09930
    Location:554 → 657
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:262 → 372
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd12924
    Location:377 → 537
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    cd04388
    Location:52 → 245
    RhoGAP_p85; RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region ...
    pfam16454
    Location:376 → 535
    PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain

  3. XM_008102908.3 → XP_008101115.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X4

    See identical proteins and their annotated locations for XP_008101115.1

    Conserved Domains (4) summary
    cd09930
    Location:296 → 399
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:4 → 114
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd12924
    Location:119 → 279
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    pfam16454
    Location:118 → 277
    PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain

  4. XM_008102907.3 → XP_008101114.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X4

    See identical proteins and their annotated locations for XP_008101114.1

    Conserved Domains (4) summary
    cd09930
    Location:296 → 399
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:4 → 114
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd12924
    Location:119 → 279
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    pfam16454
    Location:118 → 277
    PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain

  5. XM_008102905.3 → XP_008101112.1  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3

    UniProtKB/TrEMBL
    A0A803TIM1
    Related
    ENSACAP00000035061.1
    Conserved Domains (4) summary
    cd09930
    Location:347 → 450
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cd09942
    Location:55 → 165
    SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
    cd12924
    Location:170 → 330
    iSH2_PIK3R1; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 1, PIK3R1, also called p85alpha
    pfam16454
    Location:169 → 328
    PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
Nucleotide Protein
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