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IDE insulin degrading enzyme [ Pongo abelii (Sumatran orangutan) ]

Gene ID: 100434053, updated on 26-Mar-2024

Summary

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Gene symbol
IDE
Gene description
insulin degrading enzyme
Locus tag
CR201_G0037965
See related
Ensembl:ENSPPYG00000002483
Gene type
protein coding
RefSeq status
MODEL
Organism
Pongo abelii
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo
Orthologs
human mouse all
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Genomic context

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See IDE in Genome Data Viewer
Location:
chromosome: 8
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPonAbe1-v2.0_pri (GCF_028885655.2) 8 NC_071993.2 (99222936..99354126, complement)
RS_2023_04 previous assembly NHGRI_mPonAbe1-v1.1-hic.freeze_pri (GCF_028885655.1) 10 NC_071995.1 (95406397..95537525, complement)

Chromosome 8 - NC_071993.2Genomic Context describing neighboring genes Neighboring gene membrane associated ring-CH-type finger 5 Neighboring gene uncharacterized LOC134762067 Neighboring gene uncharacterized LOC129048319 Neighboring gene kinesin family member 11 Neighboring gene U2 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in amyloid-beta metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in hormone catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in peptide catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis involved in protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in peroxisomal matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
insulin-degrading enzyme

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028885655.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

Genomic

  1. NC_071993.2 Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

    Range
    99222936..99354126 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_002820978.6 → XP_002821024.1  insulin-degrading enzyme isoform X2

    UniProtKB/TrEMBL
    A0A2J8Y587, A0A6D2WTR2, H2NB07
    Related
    ENSPPYP00000002877.2
    Conserved Domains (1) summary
    COG1025
    Location:52 → 958
    Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]

  2. XM_009245626.4 → XP_009243901.1  insulin-degrading enzyme isoform X1

    UniProtKB/TrEMBL
    A0A8I5TXH8
    Related
    ENSPPYP00000032280.1
    Conserved Domains (4) summary
    COG1025
    Location:52 → 958
    Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
    pfam00675
    Location:74 → 212
    Peptidase_M16; Insulinase (Peptidase family M16)
    pfam05193
    Location:238 → 416
    Peptidase_M16_C; Peptidase M16 inactive domain
    pfam16187
    Location:422 → 703
    Peptidase_M16_M; Middle or third domain of peptidase_M16

  3. XM_024253395.3 → XP_024109163.1  insulin-degrading enzyme isoform X3

    Conserved Domains (1) summary
    COG1025
    Location:11 → 917
    Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
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