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JAK2 Janus kinase 2 [ Callithrix jacchus (white-tufted-ear marmoset) ]

Gene ID: 100413251, updated on 6-Jun-2024

Summary

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Gene symbol
JAK2
Gene description
Janus kinase 2
See related
Ensembl:ENSCJAG00000011228
Gene type
protein coding
RefSeq status
MODEL
Organism
Callithrix jacchus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix
Orthologs
human mouse all
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Genomic context

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See JAK2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2023_03 current mCalJa1.2.pat.X (GCF_011100555.1) 1 NC_071442.1 (108450801..108573420)
105 previous assembly Callithrix_jacchus_cj1700_1.1 (GCF_009663435.1) 1 NC_048383.1 (109797505..109920574)

Chromosome 1 - NC_071442.1Genomic Context describing neighboring genes Neighboring gene small nuclear ribonucleoprotein E-like Neighboring gene RNA terminal phosphate cyclase like 1 Neighboring gene protein GVQW1-like Neighboring gene eukaryotic translation initiation factor 1-like Neighboring gene DDB1- and CUL4-associated factor 16-like Neighboring gene insulin like 6 Neighboring gene relaxin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. De novo assembly of the common marmoset transcriptome from NextGen mRNA sequences. Maudhoo MD, et al. Gigascience, 2014. PMID 25243066, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cytokine receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables histone binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in hemopoiesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein kinase JAK2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_011100555.1-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mCalJa1.2.pat.X

Genomic

  1. NC_071442.1 Reference mCalJa1.2.pat.X

    Range
    108450801..108573420
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054255949.1 → XP_054111924.1  tyrosine-protein kinase JAK2

    UniProtKB/TrEMBL
    F6RLI3

  2. XM_017973423.3 → XP_017828912.2  tyrosine-protein kinase JAK2

    UniProtKB/TrEMBL
    F6RLI3
    Conserved Domains (6) summary
    cd10379
    Location:384 → 480
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    cd13333
    Location:264 → 384
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:543 → 804
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:842 → 1125
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
    pfam18377
    Location:141 → 259
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:37 → 132
    FERM_F1; FERM F1 ubiquitin-like domain

  3. XM_054255936.1 → XP_054111911.1  tyrosine-protein kinase JAK2

    UniProtKB/TrEMBL
    F6RLI3

  4. XM_002742906.6 → XP_002742952.4  tyrosine-protein kinase JAK2

    UniProtKB/TrEMBL
    F6RLI3
    Conserved Domains (6) summary
    cd10379
    Location:384 → 480
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    cd13333
    Location:264 → 384
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:543 → 804
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:842 → 1125
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
    pfam18377
    Location:141 → 259
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:37 → 132
    FERM_F1; FERM F1 ubiquitin-like domain
Nucleotide Protein
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