U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

tiam2a TIAM Rac1 associated GEF 2a [ Danio rerio (zebrafish) ]

Gene ID: 100334442, updated on 27-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
tiam2aprovided by ZNC
Official Full Name
TIAM Rac1 associated GEF 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030219-98
See related
Ensembl:ENSDARG00000087780 AllianceGenome:ZFIN:ZDB-GENE-030219-98
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
tiam2; id:ibd5033
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in activation of GTPase activity; positive regulation of axonogenesis; and small GTPase mediated signal transduction. Predicted to act upstream of or within intracellular signal transduction. Predicted to be active in membrane and synapse. Is expressed in somite and tail bud. Orthologous to human TIAM2 (TIAM Rac1 associated GEF 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 17
Exon count:
31
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (49039109..49218365)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (48999006..49135390)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene HCLS1 binding protein 3 Neighboring gene SR-related CTD-associated factor 8 Neighboring gene claudin 20 Neighboring gene transcription factor B1, mitochondrial Neighboring gene zgc:113176

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Direct activation of the Mauthner cell by electric field pulses drives ultrarapid escape responses. Tabor KM, et al. J Neurophysiol, 2014 Aug 15. PMID 24848468, Free PMC Article
  2. Presynaptic Inhibition Selectively Gates Auditory Transmission to the Brainstem Startle Circuit. Tabor KM, et al. Curr Biol, 2018 Aug 20. PMID 30078569, Free PMC Article
  3. Constitutive RAC activation is not sufficient to initiate melanocyte neoplasia but accelerates malignant progression. Dalton LE, et al. J Invest Dermatol, 2013 Jun. PMID 23337888
  4. ERK1 and ERK2 MAPK are key regulators of distinct gene sets in zebrafish embryogenesis. Krens SF, et al. BMC Genomics, 2008 Apr 28. PMID 18442396, Free PMC Article
  5. A gene expression screen in zebrafish embryogenesis. Kudoh T, et al. Genome Res, 2001 Dec. PMID 11731487

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in small GTPase-mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
T-lymphoma invasion and metastasis-inducing protein 2
Names
T cell lymphoma invasion and metastasis 2a
T-cell lymphoma invasion and metastasis 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    49039109..49218365
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021467480.1 → XP_021323155.1  T-lymphoma invasion and metastasis-inducing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M3AJ94
    Conserved Domains (5) summary
    smart00325
    Location:1100 → 1289
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:906 → 986
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:488 → 613
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1291 → 1458
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    cl00155
    Location:829 → 904
    UBQ; Ubiquitin-like proteins

  2. XM_009293288.3 → XP_009291563.1  T-lymphoma invasion and metastasis-inducing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M3AJ94
    Conserved Domains (5) summary
    smart00325
    Location:1100 → 1289
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:906 → 986
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:488 → 613
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1291 → 1458
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    cl00155
    Location:829 → 904
    UBQ; Ubiquitin-like proteins

  3. XM_009293289.3 → XP_009291564.1  T-lymphoma invasion and metastasis-inducing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A286Y9S9, A0A8M3B2N1
    Related
    ENSDARP00000143330.1, ENSDART00000177166.2
    Conserved Domains (6) summary
    cd00992
    Location:891 → 971
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:488 → 613
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1276 → 1443
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam00169
    Location:490 → 602
    PH; PH domain
    pfam00621
    Location:1085 → 1274
    RhoGEF; RhoGEF domain
    cl00155
    Location:814 → 889
    UBQ; Ubiquitin-like proteins

  4. XM_009293290.3 → XP_009291565.1  T-lymphoma invasion and metastasis-inducing protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8M3AK43
    Conserved Domains (2) summary
    cd01255
    Location:333 → 500
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam00621
    Location:142 → 331
    RhoGEF; RhoGEF domain

  5. XM_021467481.1 → XP_021323156.1  T-lymphoma invasion and metastasis-inducing protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A8M9PLL7
    Conserved Domains (2) summary
    smart00325
    Location:87 → 276
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01255
    Location:278 → 445
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.