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TIAM2 TIAM Rac1 associated GEF 2 [ Homo sapiens (human) ]

Gene ID: 26230, updated on 6-Sep-2021

Summary

Official Symbol
TIAM2provided by HGNC
Official Full Name
TIAM Rac1 associated GEF 2provided by HGNC
Primary source
HGNC:HGNC:11806
See related
Ensembl:ENSG00000146426 MIM:604709
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STEF; TIAM-2
Summary
This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 5.7), brain (RPKM 4.1) and 18 other tissues See more
Orthologs
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Genomic context

See TIAM2 in Genome Data Viewer
Location:
6q25.2-q25.3
Exon count:
30
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (154995315..155257723)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (155316449..155578857)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene SR-related CTD associated factor 8 Neighboring gene RNA, U6 small nuclear 824, pseudogene Neighboring gene microRNA 1273c Neighboring gene lysophosphatidylcholine acyltransferase 3 pseudogene Neighboring gene transcription factor B1, mitochondrial Neighboring gene claudin 20 Neighboring gene NADPH oxidase 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of T-cell lymphoma invasion and metastasis 2 (TIAM2) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: SCAF8

Homology

Clone Names

  • FLJ41865

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
involved_in small GTPase mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in filopodium IEA
Inferred from Electronic Annotation
more info
 
located_in growth cone IEA
Inferred from Electronic Annotation
more info
 
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
rho guanine nucleotide exchange factor TIAM2
Names
SIF and TIAM1-like exchange factor
T cell lymphoma invasion and metastasis 2
T-lymphoma invasion and metastasis-inducing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010927.3NP_001010927.2  rho guanine nucleotide exchange factor TIAM2 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL139101, AL355343, AL596202
    Consensus CDS
    CCDS34559.1
    Related
    ENSP00000275246.7, ENST00000275246.11
    Conserved Domains (2) summary
    smart00325
    Location:28217
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01255
    Location:219391
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
  2. NM_001384546.1NP_001371475.1  rho guanine nucleotide exchange factor TIAM2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL136228, AL139101, AL355343, AL596202
    Related
    ENSP00000437188.2, ENST00000461783.7
    Conserved Domains (6) summary
    smart00325
    Location:11031292
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:888973
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:505631
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:12941466
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam18385
    Location:645742
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
    cl28922
    Location:811881
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  3. NM_001384547.1NP_001371476.1  rho guanine nucleotide exchange factor TIAM2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL139101, AL355343, AL596202
    Related
    ENSP00000353528.4, ENST00000360366.8
    Conserved Domains (6) summary
    smart00325
    Location:11031292
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:888973
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:505631
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:12941466
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam18385
    Location:645742
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
    cl28922
    Location:811881
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  4. NM_012454.4NP_036586.3  rho guanine nucleotide exchange factor TIAM2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL136228, AL139101, AL355343, AL596202
    Consensus CDS
    CCDS34558.1
    Related
    ENSP00000507157.1, ENST00000682666.1
    Conserved Domains (6) summary
    smart00325
    Location:11031292
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:888973
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:505631
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:12941466
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    pfam18385
    Location:645742
    Tiam_CC_Ex; T-lymphoma invasion and metastasis CC-Ex domain
    cl28922
    Location:811881
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    154995315..155257723
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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