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TIAM2 TIAM Rac1 associated GEF 2 [ Homo sapiens (human) ]

Gene ID: 26230, updated on 21-Jun-2020

Summary

Official Symbol
TIAM2provided by HGNC
Official Full Name
TIAM Rac1 associated GEF 2provided by HGNC
Primary source
HGNC:HGNC:11806
See related
Ensembl:ENSG00000146426 MIM:604709
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STEF; TIAM-2
Summary
This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 5.7), brain (RPKM 4.1) and 18 other tissues See more
Orthologs

Genomic context

See TIAM2 in Genome Data Viewer
Location:
6q25.2-q25.3
Exon count:
27
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (155090289..155257723)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (155316488..155578857)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene microRNA 1273c Neighboring gene lysophosphatidylcholine acyltransferase 3 pseudogene Neighboring gene transcription factor B1, mitochondrial Neighboring gene claudin 20 Neighboring gene NADPH oxidase 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of T-cell lymphoma invasion and metastasis 2 (TIAM2) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: SCAF8

Homology

Clone Names

  • FLJ41865

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
Rac guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of apoptotic process TAS
Traceable Author Statement
more info
 
positive regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of lipid metabolic process TAS
Traceable Author Statement
more info
 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
small GTPase mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
filopodium IEA
Inferred from Electronic Annotation
more info
 
growth cone IEA
Inferred from Electronic Annotation
more info
 
lamellipodium IEA
Inferred from Electronic Annotation
more info
 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
perikaryon IEA
Inferred from Electronic Annotation
more info
 
synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
T-lymphoma invasion and metastasis-inducing protein 2
Names
SIF and TIAM1-like exchange factor
T cell lymphoma invasion and metastasis 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010927.3NP_001010927.2  T-lymphoma invasion and metastasis-inducing protein 2 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL139101, AL355343, AL596202
    Consensus CDS
    CCDS34559.1
    Related
    ENSP00000275246.7, ENST00000275246.11
  2. NM_001384546.1NP_001371475.1  T-lymphoma invasion and metastasis-inducing protein 2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL136228, AL139101, AL355343, AL596202
  3. NM_001384547.1NP_001371476.1  T-lymphoma invasion and metastasis-inducing protein 2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL139101, AL355343, AL596202
  4. NM_012454.4NP_036586.3  T-lymphoma invasion and metastasis-inducing protein 2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL136228, AL139101, AL355343, AL596202
    Consensus CDS
    CCDS34558.1
    Related
    ENSP00000437188.2, ENST00000461783.7

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    155090289..155257723
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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