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GRB10 growth factor receptor bound protein 10 [ Sus scrofa (pig) ]

Gene ID: 100188977, updated on 8-Mar-2024

Summary

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Official Symbol
GRB10provided by VGNC
Official Full Name
growth factor receptor bound protein 10provided by VGNC
Primary source
VGNC:VGNC:88662
See related
Ensembl:ENSSSCG00000015631
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression
Ubiquitous expression in longissimus dorsi muscle (RPKM 8.5), psoas major muscle (RPKM 8.1) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See GRB10 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
25
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 9 NC_010451.4 (136580363..136742552, complement)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 9 NC_010451.3 (150268567..150398500, complement)

Chromosome 9 - NC_010451.4Genomic Context describing neighboring genes Neighboring gene fidgetin like 1 Neighboring gene dopa decarboxylase Neighboring gene cordon-bleu WH2 repeat protein Neighboring gene uncharacterized LOC106505064

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences. Uenishi H, et al. Nucleic Acids Res, 2007 Jan. PMID 17145712, Free PMC Article
  2. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables insulin receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
growth factor receptor-bound protein 10
Names
GRB10 adapter protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134965.1 → NP_001128437.1  growth factor receptor-bound protein 10

    See identical proteins and their annotated locations for NP_001128437.1

    Status: PROVISIONAL

    Source sequence(s)
    EF174195
    UniProtKB/Swiss-Prot
    B5KFD3, B5KFD4, B5KFD6, B5KFD7
    UniProtKB/TrEMBL
    A0A8D1NIL4
    Conserved Domains (4) summary
    cd01787
    Location:161 → 243
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:482 → 589
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:281 → 403
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:421 → 462
    BPS; BPS (Between PH and SH2)

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010451.4 Reference Sscrofa11.1 Primary Assembly

    Range
    136580363..136742552 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021101958.1 → XP_020957617.1  growth factor receptor-bound protein 10 isoform X3

    UniProtKB/TrEMBL
    A0A8D1FET8
    Conserved Domains (4) summary
    cd01787
    Location:102 → 184
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:423 → 530
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:222 → 344
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:362 → 403
    BPS; BPS (Between PH and SH2)

  2. XM_021101955.1 → XP_020957614.1  growth factor receptor-bound protein 10 isoform X1

    UniProtKB/Swiss-Prot
    B5KFD3, B5KFD4, B5KFD6, B5KFD7
    UniProtKB/TrEMBL
    A0A8D1NIL4
    Related
    ENSSSCP00000031279.1, ENSSSCT00000060494.2
    Conserved Domains (4) summary
    cd01787
    Location:161 → 243
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:482 → 589
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:281 → 403
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:421 → 462
    BPS; BPS (Between PH and SH2)

  3. XM_021101957.1 → XP_020957616.1  growth factor receptor-bound protein 10 isoform X3

    UniProtKB/TrEMBL
    A0A8D1FET8
    Conserved Domains (4) summary
    cd01787
    Location:102 → 184
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:423 → 530
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:222 → 344
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:362 → 403
    BPS; BPS (Between PH and SH2)

  4. XM_021101965.1 → XP_020957624.1  growth factor receptor-bound protein 10 isoform X3

    UniProtKB/TrEMBL
    A0A8D1FET8
    Conserved Domains (4) summary
    cd01787
    Location:102 → 184
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:423 → 530
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:222 → 344
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:362 → 403
    BPS; BPS (Between PH and SH2)

  5. XM_021101963.1 → XP_020957622.1  growth factor receptor-bound protein 10 isoform X6

    UniProtKB/TrEMBL
    A0A8D0LFR9
    Conserved Domains (4) summary
    cd01787
    Location:46 → 125
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:364 → 471
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:163 → 285
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:303 → 344
    BPS; BPS (Between PH and SH2)

  6. XM_021101966.1 → XP_020957625.1  growth factor receptor-bound protein 10 isoform X3

    UniProtKB/TrEMBL
    A0A8D1FET8
    Conserved Domains (4) summary
    cd01787
    Location:102 → 184
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:423 → 530
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:222 → 344
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:362 → 403
    BPS; BPS (Between PH and SH2)

  7. XM_021101962.1 → XP_020957621.1  growth factor receptor-bound protein 10 isoform X5

    UniProtKB/TrEMBL
    A0A8D0LFR9
    Conserved Domains (4) summary
    cd01787
    Location:55 → 134
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:373 → 480
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:172 → 294
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:312 → 353
    BPS; BPS (Between PH and SH2)

  8. XM_021101959.1 → XP_020957618.1  growth factor receptor-bound protein 10 isoform X3

    UniProtKB/TrEMBL
    A0A8D1FET8
    Conserved Domains (4) summary
    cd01787
    Location:102 → 184
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:423 → 530
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:222 → 344
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:362 → 403
    BPS; BPS (Between PH and SH2)

  9. XM_021101964.1 → XP_020957623.1  growth factor receptor-bound protein 10 isoform X7

    UniProtKB/TrEMBL
    A0A8D0LFR9
    Conserved Domains (4) summary
    cd01787
    Location:15 → 94
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd10415
    Location:333 → 440
    SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
    cd01259
    Location:132 → 254
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:272 → 313
    BPS; BPS (Between PH and SH2)

  10. XM_021101960.1 → XP_020957619.1  growth factor receptor-bound protein 10 isoform X4

    UniProtKB/TrEMBL
    A0A8D1SZB1
    Conserved Domains (4) summary
    cd01787
    Location:102 → 184
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd01259
    Location:222 → 344
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:362 → 403
    BPS; BPS (Between PH and SH2)
    cl15255
    Location:423 → 451
    SH2; Src homology 2 (SH2) domain

  11. XM_021101956.1 → XP_020957615.1  growth factor receptor-bound protein 10 isoform X2

    UniProtKB/TrEMBL
    A0A8D1C0B1
    Related
    ENSSSCP00000057939.2, ENSSSCT00000057201.2
    Conserved Domains (4) summary
    cd01787
    Location:161 → 243
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd01259
    Location:281 → 403
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:421 → 462
    BPS; BPS (Between PH and SH2)
    cl15255
    Location:482 → 510
    SH2; Src homology 2 (SH2) domain

  12. XM_021101961.1 → XP_020957620.1  growth factor receptor-bound protein 10 isoform X4

    UniProtKB/TrEMBL
    A0A8D1SZB1
    Conserved Domains (4) summary
    cd01787
    Location:102 → 184
    GRB7_RA; RA (RAS-associated like) domain of Grb7
    cd01259
    Location:222 → 344
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    pfam08947
    Location:362 → 403
    BPS; BPS (Between PH and SH2)
    cl15255
    Location:423 → 451
    SH2; Src homology 2 (SH2) domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B5KFD7.1 GenPept UniProtKB/Swiss-Prot:B5KFD7

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