OAZ2 ornithine decarboxylase antizyme 2 [Pongo abelii (Sumatran orangutan)] - Gene

Summary

Gene symbol: OAZ2
Gene description: ornithine decarboxylase antizyme 2
Locus tag: CR201_G0037081
See related: Ensembl:ENSPPYG00000006552
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Pongo abelii
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo
Summary: The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo, however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. [provided by RefSeq, Aug 2014]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPonAbe1-v2.0_pri (GCF_028885655.2)	16	NC_072001.2 (67768349..67783967, complement)
RS_2023_04	previous assembly	NHGRI_mPonAbe1-v1.1-hic.freeze_pri (GCF_028885655.1)	15	NC_072000.1 (65048011..65063629, complement)

Chromosome 16 - NC_072001.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Oaz2-ps (e-PCR), detects polymorphism
- UniSTS:531479

Oaz2 (e-PCR), detects polymorphism
- UniSTS:527466

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ornithine decarboxylase inhibitor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: ornithine decarboxylase antizyme 2

Names: AZ2; ODC-Az 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001133124.1 → NP_001126596.1 ornithine decarboxylase antizyme 2

See identical proteins and their annotated locations for NP_001126596.1

Status: REVIEWED

Source sequence(s)

CR860615

UniProtKB/Swiss-Prot

Q5R680

UniProtKB/TrEMBL

A0A2J8T8A4, H2NNH2

Related

ENSPPYP00000007433.2, ENSPPYT00000007737.3

Conserved Domains (1) summary

pfam02100
Location:100 → 181

ODC_AZ; Ornithine decarboxylase antizyme

RefSeqs of Annotated Genomes: GCF_028885655.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

Genomic

NC_072001.2 Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

Range

67768349..67783967 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)