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DHTKD1 dehydrogenase E1 and transketolase domain containing 1 [ Pongo abelii (Sumatran orangutan) ]

Gene ID: 100173320, updated on 3-Apr-2024

Summary

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Gene symbol
DHTKD1
Gene description
dehydrogenase E1 and transketolase domain containing 1
Locus tag
CR201_G0018282
See related
Ensembl:ENSPPYG00000002833
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pongo abelii
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo
Also known as
E1a; OADC-E1; OADH-E1
Orthologs
human mouse all
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Genomic context

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See DHTKD1 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPonAbe1-v2.0_pri (GCF_028885655.2) 8 NC_071993.2 (12199768..12260336)
RS_2023_04 previous assembly NHGRI_mPonAbe1-v1.1-hic.freeze_pri (GCF_028885655.1) 10 NC_071995.1 (12198632..12258607)

Chromosome 8 - NC_071993.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112135247 Neighboring gene proline and serine rich 2 Neighboring gene U6 spliceosomal RNA Neighboring gene UPF2 regulator of nonsense mediated mRNA decay Neighboring gene U6 spliceosomal RNA Neighboring gene small nucleolar RNA U13 Neighboring gene SEC61 translocon subunit alpha 2 Neighboring gene nudix hydrolase 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • DKFZp469C0919

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables oxoglutarate dehydrogenase (succinyl-transferring) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables thiamine pyrophosphate binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
2-oxoadipate dehydrogenase complex component E1
Names
2-oxoadipate dehydrogenase, mitochondrial
Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial
alpha-KADH-E1
alpha-ketoadipate dehydrogenase
dehydrogenase E1 and transketolase domain-containing protein 1
NP_001126339.1
XP_024108853.1
XP_054377620.1
XP_054377621.1
XP_054377622.1
XP_054377623.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001132867.2 → NP_001126339.1  2-oxoadipate dehydrogenase complex component E1

    See identical proteins and their annotated locations for NP_001126339.1

    Status: PROVISIONAL

    Source sequence(s)
    CR860147
    UniProtKB/Swiss-Prot
    Q5R7H0
    UniProtKB/TrEMBL
    A0A2J8VKC6, A0A8I5YQF6
    Related
    ENSPPYP00000033157.1, ENSPPYT00000049244.1
    Conserved Domains (4) summary
    PRK09404
    Location:58 → 919
    sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
    cd02016
    Location:176 → 449
    TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...
    pfam02779
    Location:568 → 771
    Transket_pyr; Transketolase, pyrimidine binding domain
    pfam16870
    Location:778 → 918
    OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal

RefSeqs of Annotated Genomes: GCF_028885655.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

Genomic

  1. NC_071993.2 Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

    Range
    12199768..12260336
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054521646.2 → XP_054377621.1  2-oxoadipate dehydrogenase complex component E1 isoform X3

  2. XM_054521645.2 → XP_054377620.1  2-oxoadipate dehydrogenase complex component E1 isoform X2

  3. XM_024253085.3 → XP_024108853.1  2-oxoadipate dehydrogenase complex component E1 isoform X1

    UniProtKB/TrEMBL
    A0A2J8VKC6, A0A8I5YQF6, H2NC65
    Related
    ENSPPYP00000003298.3
    Conserved Domains (1) summary
    cl25580
    Location:58 → 880
    OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal

  4. XM_054521647.2 → XP_054377622.1  2-oxoadipate dehydrogenase complex component E1 isoform X4

  5. XM_054521648.2 → XP_054377623.1  2-oxoadipate dehydrogenase complex component E1 isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5R7H0.1 GenPept UniProtKB/Swiss-Prot:Q5R7H0

Gene LinkOut

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