lgr4 leucine-rich repeat containing G protein-coupled receptor 4 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: lgr4provided by Xenbase
Official Full Name: leucine-rich repeat containing G protein-coupled receptor 4provided by Xenbase
Primary source: Xenbase:XB-GENE-5959108
See related: Ensembl:ENSXETG00000030403
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	4	NC_030680.2 (21077274..21157562)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	4	NC_030680.1 (11872155..11953020)

Chromosome 4 - NC_030680.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Crystal structures of the Lgr4 ectodomain alone and bound to Rspo1.
Title: Crystal structures of Lgr4 and its complex with R-spondin1.
Multi-functional norrin is a ligand for the LGR4 receptor.
Title: Multi-functional norrin is a ligand for the LGR4 receptor.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
NOT enables G protein-coupled receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-hormone receptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in activation of adenylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within bone mineralization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within bone remodeling	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cytokine production	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of toll-like receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within osteoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within rhythmic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spermatogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: leucine-rich repeat-containing G-protein coupled receptor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001126498.1 → NP_001119970.1 leucine-rich repeat-containing G-protein coupled receptor 4 precursor

See identical proteins and their annotated locations for NP_001119970.1

Status: PROVISIONAL

Source sequence(s)

BC158183

UniProtKB/Swiss-Prot

B0BLW3, F6US71

UniProtKB/TrEMBL

A0A6I8S8T9

Related

ENSXETP00000089604.2, ENSXETT00000078503.2

Conserved Domains (4) summary

PLN00113
Location:53 → 445

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00031
Location:323 → 344

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:61 → 84

LRR_RI; leucine-rich repeat [structural motif]

cd15361
Location:542 → 815

7tmA_LGR4; leucine-rich repeats-containing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors