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LGR4 leucine rich repeat containing G protein-coupled receptor 4 [ Homo sapiens (human) ]

Gene ID: 55366, updated on 8-Aug-2021

Summary

Official Symbol
LGR4provided by HGNC
Official Full Name
leucine rich repeat containing G protein-coupled receptor 4provided by HGNC
Primary source
HGNC:HGNC:13299
See related
Ensembl:ENSG00000205213 MIM:606666
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPR48; BNMD17
Summary
The protein encoded by this gene is a G-protein coupled receptor that binds R-spondins and activates the Wnt signaling pathway. This Wnt signaling pathway activation is necessary for proper development of many organs of the body. [provided by RefSeq, Oct 2016]
Expression
Ubiquitous expression in kidney (RPKM 28.0), colon (RPKM 27.7) and 23 other tissues See more
Orthologs
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Genomic context

See LGR4 in Genome Data Viewer
Location:
11p14.1
Exon count:
18
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (27365961..27472790, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (27387508..27494337, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376601 Neighboring gene coiled-coil domain containing 34 Neighboring gene Sharpr-MPRA regulatory region 4633 Neighboring gene LGR4 antisense RNA 1 Neighboring gene ribosomal protein L37a pseudogene 7 Neighboring gene lin-7 homolog C, crumbs cell polarity complex component

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Bone mineral density quantitative trait locus 17
MedGen: C3714987 OMIM: 615311 GeneReviews: Not available
not available
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
GeneReviews: Not available
Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-hormone receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in activation of adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in bone mineralization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in bone remodeling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in canonical Wnt signaling pathway involved in metanephric kidney development IEA
Inferred from Electronic Annotation
more info
 
involved_in cell differentiation involved in metanephros development IEA
Inferred from Electronic Annotation
more info
 
involved_in circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in digestive tract development IEA
Inferred from Electronic Annotation
more info
 
involved_in epithelial cell proliferation involved in renal tubule morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in hair follicle development IEA
Inferred from Electronic Annotation
more info
 
involved_in hormone-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in intestinal stem cell homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in male genitalia development IEA
Inferred from Electronic Annotation
more info
 
involved_in metanephric glomerulus development IEA
Inferred from Electronic Annotation
more info
 
involved_in metanephric nephron tubule morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in negative regulation of cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of toll-like receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
involved_in osteoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of branching involved in ureteric bud morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
involved_in spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
leucine-rich repeat-containing G-protein coupled receptor 4
Names
G protein-coupled receptor 48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051818.1 RefSeqGene

    Range
    5001..111815
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001346432.2NP_001333361.1  leucine-rich repeat-containing G-protein coupled receptor 4 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC090597, AC100771
    Consensus CDS
    CCDS86187.1
    UniProtKB/Swiss-Prot
    Q9BXB1
    UniProtKB/TrEMBL
    Q59ER8
    Related
    ENSP00000374508.4, ENST00000389858.4
  2. NM_018490.5NP_060960.2  leucine-rich repeat-containing G-protein coupled receptor 4 isoform 1 precursor

    See identical proteins and their annotated locations for NP_060960.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC090597, AC100771
    Consensus CDS
    CCDS31449.1
    UniProtKB/Swiss-Prot
    Q9BXB1
    UniProtKB/TrEMBL
    Q59ER8
    Related
    ENSP00000368516.4, ENST00000379214.9
    Conserved Domains (5) summary
    cd00116
    Location:44239
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:5982
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00001
    Location:556801
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam01462
    Location:2956
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:177237
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    27365961..27472790 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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