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cubn cubilin (intrinsic factor-cobalamin receptor) [ Danio rerio (zebrafish) ]

Gene ID: 100144772, updated on 12-Sep-2024

Summary

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Official Symbol
cubnprovided by ZNC
Official Full Name
cubilin (intrinsic factor-cobalamin receptor)provided by ZNC
Primary source
ZFIN:ZDB-GENE-060228-6
See related
Ensembl:ENSDARG00000087013 AllianceGenome:ZFIN:ZDB-GENE-060228-6
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable calcium ion binding activity; cargo receptor activity; and cobalamin binding activity. Predicted to act upstream of or within cholesterol metabolic process and protein transport. Predicted to be located in endosome; lysosomal membrane; and plasma membrane. Is expressed in pronephric duct; pronephric tubule; pronephros; proximal convoluted tubule; and proximal straight tubule. Orthologous to human CUBN (cubilin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 24
Exon count:
66
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (32035626..32150405, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (32120980..32233249, complement)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene complement component 1, q subcomponent-like 3a Neighboring gene Ras suppressor protein 1 Neighboring gene tRNA aspartic acid methyltransferase 1 Neighboring gene vimentin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Comparative genomic analysis of slc39a12/ZIP12: insight into a zinc transporter required for vertebrate nervous system development. Chowanadisai W. PLoS One, 2014. PMID 25375179, Free PMC Article
  2. Elucidation of megalin/LRP2-dependent endocytic transport processes in the larval zebrafish pronephros. Anzenberger U, et al. J Cell Sci, 2006 May 15. PMID 16638803
  3. Analysis of nephron composition and function in the adult zebrafish kidney. McCampbell KK, et al. J Vis Exp, 2014 Aug 9. PMID 25145398, Free PMC Article
  4. Lysosome-Rich Enterocytes Mediate Protein Absorption in the Vertebrate Gut. Park J, et al. Dev Cell, 2019 Oct 7. PMID 31474562, Free PMC Article
  5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in animal organ development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cubilin

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    32035626..32150405 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021470374.2 → XP_021326049.1  cubilin

    UniProtKB/TrEMBL
    A0A8M9PME6
    Related
    ENSDARP00000135504.1, ENSDART00000166212.2
    Conserved Domains (5) summary
    cd00041
    Location:1522 → 1632
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00054
    Location:433 → 469
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00431
    Location:1058 → 1166
    CUB; CUB domain
    pfam07645
    Location:260 → 299
    EGF_CA; Calcium-binding EGF domain
    pfam12947
    Location:352 → 387
    EGF_3; EGF domain
Nucleotide Protein Strain
Heading Accession and Version

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