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adam22 ADAM metallopeptidase domain 22 [ Danio rerio (zebrafish) ]

Gene ID: 100126805, updated on 17-Sep-2024

Summary

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Official Symbol
adam22provided by ZNC
Official Full Name
ADAM metallopeptidase domain 22provided by ZNC
Primary source
ZFIN:ZDB-GENE-070810-1
See related
Ensembl:ENSDARG00000060532 AllianceGenome:ZFIN:ZDB-GENE-070810-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:173905
Summary
Predicted to enable metalloendopeptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of postsynaptic density membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 61. Orthologous to human ADAM22 (ADAM metallopeptidase domain 22). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 16
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (43152922..43286157)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (43248969..43381352)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 40 Neighboring gene DBF4-CDC7 kinase regulatory subunit Neighboring gene claudin 12 Neighboring gene WASH complex subunit 5 Neighboring gene proteasome 20S subunit alpha 2a Neighboring gene mitochondrial ribosomal protein L32

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Phylogenetic and evolutionary relationships and developmental expression patterns of the zebrafish twist gene family. Yeo GH, et al. Dev Genes Evol, 2009 Jun. PMID 19565261
  2. The evolution of the vertebrate metzincins; insights from Ciona intestinalis and Danio rerio. Huxley-Jones J, et al. BMC Evol Biol, 2007 Apr 17. PMID 17439641, Free PMC Article
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
disintegrin and metalloproteinase domain-containing protein 22
Names
a disintegrin and metallopeptidase domain 22

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    43152922..43286157
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_002664981.7 → XP_002665027.3  disintegrin and metalloproteinase domain-containing protein 22 isoform X4

    UniProtKB/TrEMBL
    A0A8M1RE30, F1QF43
    Related
    ENSDARP00000111920.1, ENSDART00000125590.4
    Conserved Domains (5) summary
    smart00608
    Location:531 → 672
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:242 → 437
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:454 → 528
    Disintegrin; Disintegrin
    pfam01421
    Location:242 → 439
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:81 → 190
    Pep_M12B_propep; Reprolysin family propeptide

  2. XM_021467004.2 → XP_021322679.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X1

    UniProtKB/TrEMBL
    A0A8M9PDU9
    Conserved Domains (4) summary
    smart00608
    Location:531 → 672
    ACR; ADAM Cysteine-Rich Domain
    pfam00200
    Location:454 → 527
    Disintegrin
    pfam01562
    Location:74 → 191
    Pep_M12B_propep; Reprolysin family propeptide
    cl26139
    Location:242 → 439
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease

  3. XM_009292610.4 → XP_009290885.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X2

    UniProtKB/TrEMBL
    A0A8M3AJF6
    Conserved Domains (5) summary
    smart00608
    Location:531 → 672
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:242 → 437
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:454 → 528
    Disintegrin; Disintegrin
    pfam01421
    Location:242 → 439
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:81 → 190
    Pep_M12B_propep; Reprolysin family propeptide

  4. XM_068214233.1 → XP_068070334.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X3

  5. XM_009292611.2 → XP_009290886.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X5

    UniProtKB/TrEMBL
    A0A8M3ATT0
    Conserved Domains (5) summary
    smart00608
    Location:531 → 672
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:242 → 437
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam00200
    Location:454 → 528
    Disintegrin; Disintegrin
    pfam01421
    Location:242 → 439
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:81 → 190
    Pep_M12B_propep; Reprolysin family propeptide

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001111085.1: Suppressed sequence

    Description
    NM_001111085.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript and the encoded protein.
Nucleotide Protein Strain
Heading Accession and Version

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