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OGDH oxoglutarate dehydrogenase [ Equus caballus (horse) ]

Gene ID: 100065225, updated on 8-Mar-2024

Summary

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Official Symbol
OGDHprovided by VGNC
Official Full Name
oxoglutarate dehydrogenaseprovided by VGNC
Primary source
VGNC:VGNC:21013
See related
Ensembl:ENSECAG00000023953
Gene type
protein coding
RefSeq status
MODEL
Organism
Equus caballus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Orthologs
human mouse all
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Genomic context

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See OGDH in Genome Data Viewer
Location:
chromosome: 4
Exon count:
25
Annotation release Status Assembly Chr Location
103 current EquCab3.0 (GCF_002863925.1) 4 NC_009147.3 (15290098..15369636)
102 previous assembly EquCab2.0 (GCF_000002305.2) 4 NC_009147.2 (15368875..15448354)

Chromosome 4 - NC_009147.3Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111773144 Neighboring gene transmembrane p24 trafficking protein 4 Neighboring gene zinc finger MIZ-type containing 2 Neighboring gene peptidylprolyl isomerase A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables oxoglutarate dehydrogenase (succinyl-transferring) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables thiamine pyrophosphate binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of oxoglutarate dehydrogenase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
2-oxoglutarate dehydrogenase, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Equus caballus Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference EquCab3.0 Primary Assembly

Genomic

  1. NC_009147.3 Reference EquCab3.0 Primary Assembly

    Range
    15290098..15369636
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005609120.2 → XP_005609177.1  2-oxoglutarate dehydrogenase, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_005609177.1

    UniProtKB/TrEMBL
    F6WSE2, F6WSG0
    Related
    ENSECAP00000021677.3, ENSECAT00000026022.3
    Conserved Domains (5) summary
    PRK09404
    Location:49 → 1026
    sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
    cd02016
    Location:275 → 538
    TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...
    pfam02779
    Location:660 → 875
    Transket_pyr; Transketolase, pyrimidine binding domain
    pfam16078
    Location:47 → 82
    2-oxogl_dehyd_N; 2-oxoglutarate dehydrogenase N-terminus
    pfam16870
    Location:882 → 1025
    OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal

  2. XM_003364758.3 → XP_003364806.1  2-oxoglutarate dehydrogenase, mitochondrial isoform X4

    See identical proteins and their annotated locations for XP_003364806.1

    UniProtKB/TrEMBL
    F6WSE2
    Related
    ENSECAP00000082433.1, ENSECAT00000116022.1
    Conserved Domains (5) summary
    PRK09404
    Location:49 → 1011
    sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
    cd02016
    Location:260 → 523
    TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...
    pfam02779
    Location:645 → 860
    Transket_pyr; Transketolase, pyrimidine binding domain
    pfam16078
    Location:47 → 82
    2-oxogl_dehyd_N; 2-oxoglutarate dehydrogenase N-terminus
    pfam16870
    Location:867 → 1010
    OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal

  3. XM_005609119.2 → XP_005609176.1  2-oxoglutarate dehydrogenase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_005609176.1

    UniProtKB/TrEMBL
    A0A9L0RI99, F6WSE2
    Related
    ENSECAP00000061396.1, ENSECAT00000095580.1
    Conserved Domains (5) summary
    PRK09404
    Location:49 → 1030
    sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
    cd02016
    Location:279 → 542
    TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...
    pfam02779
    Location:664 → 879
    Transket_pyr; Transketolase, pyrimidine binding domain
    pfam16078
    Location:47 → 82
    2-oxogl_dehyd_N; 2-oxoglutarate dehydrogenase N-terminus
    pfam16870
    Location:886 → 1029
    OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal

  4. XM_001496616.5 → XP_001496666.1  2-oxoglutarate dehydrogenase, mitochondrial isoform X3

    See identical proteins and their annotated locations for XP_001496666.1

    UniProtKB/TrEMBL
    F6WSE2
    Related
    ENSECAP00000021678.2, ENSECAT00000026023.3
    Conserved Domains (5) summary
    PRK09404
    Location:49 → 1015
    sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
    cd02016
    Location:264 → 527
    TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...
    pfam02779
    Location:649 → 864
    Transket_pyr; Transketolase, pyrimidine binding domain
    pfam16078
    Location:47 → 82
    2-oxogl_dehyd_N; 2-oxoglutarate dehydrogenase N-terminus
    pfam16870
    Location:871 → 1014
    OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal
Nucleotide Protein
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