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Ogdh oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) [ Mus musculus (house mouse) ]

Gene ID: 18293, updated on 14-May-2024

Summary

Official Symbol
Ogdhprovided by MGI
Official Full Name
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)provided by MGI
Primary source
MGI:MGI:1098267
See related
Ensembl:ENSMUSG00000020456 AllianceGenome:MGI:1098267
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E1o; d1401; OGDH-E1; mKIAA4192; 2210403E04Rik; 2210412K19Rik
Summary
Enables oxoglutarate dehydrogenase (NAD+) activity. Acts upstream of or within brain development. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human OGDH (oxoglutarate dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart adult (RPKM 260.2), kidney adult (RPKM 89.4) and 22 other tissues See more
Orthologs
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Genomic context

See Ogdh in Genome Data Viewer
Location:
11 A1; 11 3.94 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (6241597..6309094)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (6291597..6359094)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:6167755-6167938 Neighboring gene DEAD box helicase 56 Neighboring gene STARR-positive B cell enhancer ABC_E9136 Neighboring gene transmembrane p24 trafficking protein 4 Neighboring gene STARR-positive B cell enhancer ABC_E6948 Neighboring gene STARR-positive B cell enhancer ABC_E2347 Neighboring gene predicted gene, 46270 Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_28459 Neighboring gene STARR-seq mESC enhancer starr_28461 Neighboring gene zinc finger, MIZ-type containing 2 Neighboring gene STARR-seq mESC enhancer starr_28463 Neighboring gene microRNA 7651 Neighboring gene STARR-positive B cell enhancer ABC_E5206 Neighboring gene peptidylprolyl isomerase A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA4192

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in 2-oxoglutarate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in NADH metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cerebellar cortex development IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within glycolytic process IEA
Inferred from Electronic Annotation
more info
 
involved_in hippocampus development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in olfactory bulb mitral cell layer development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in pyramidal neuron development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in striatum development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in succinyl-CoA metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in tangential migration from the subventricular zone to the olfactory bulb IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in thalamus development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in tricarboxylic acid cycle ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of oxoglutarate dehydrogenase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of oxoglutarate dehydrogenase complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of oxoglutarate dehydrogenase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
2-oxoglutarate dehydrogenase complex component E1
Names
2-oxoglutarate dehydrogenase, mitochondrial
OGDC-E1
alpha-KGDH-E1
alpha-ketoglutarate dehydrogenase
oxoglutarate dehydrogenase (lipoamide)
thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase
NP_001239211.1
NP_001239212.1
NP_001239216.1
NP_001239217.1
NP_001348831.1
NP_001348832.1
NP_001348833.1
NP_001348834.1
NP_035086.2
XP_006514645.1
XP_006514647.1
XP_030101508.1
XP_030101509.1
XP_030101510.1
XP_030101511.1
XP_030101512.1
XP_036012306.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252282.1NP_001239211.1  2-oxoglutarate dehydrogenase complex component E1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK147289, AK169286, AK220536, AL607152
    UniProtKB/Swiss-Prot
    Q60597
    Conserved Domains (5) summary
    PRK09404
    Location:491030
    sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
    cd02016
    Location:279542
    TPP_E1_OGDC_like; Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of ...
    pfam02779
    Location:664879
    Transket_pyr; Transketolase, pyrimidine binding domain
    pfam16078
    Location:4782
    2-oxogl_dehyd_N; 2-oxoglutarate dehydrogenase N-terminus
    pfam16870
    Location:8861029
    OxoGdeHyase_C; 2-oxoglutarate dehydrogenase C-terminal
  2. NM_001252283.1NP_001239212.1  2-oxoglutarate dehydrogenase complex component E1 isoform 2

    See identical proteins and their annotated locations for NP_001239212.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate coding exon, compared to variant 1. The resulting isoform (2) has a shorter and different internal segment, compared to isoform 1. Variants 2, 6 and 7 encode the same isoform (2).
    Source sequence(s)
    AK147289, AL607152, BC057354
    Consensus CDS
    CCDS56758.1
    UniProtKB/Swiss-Prot
    Q60597
    Related
    ENSMUSP00000091041.4, ENSMUST00000093350.10
    Conserved Domains (1) summary
    PRK09404
    Location:491026
    sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
  3. NM_001252287.2NP_001239216.1  2-oxoglutarate dehydrogenase complex component E1 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001239216.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and a region of the coding sequence, compared to variant 1. The resulting isoform (3) has a shorter and different internal segment, compared to isoform 1. Variants 3, 4 and 8 encode the same isoform (3).
    Source sequence(s)
    AK147289, AL607152, BY768178, CJ145669
    Consensus CDS
    CCDS36106.1
    UniProtKB/Swiss-Prot
    Q3UDM7, Q5DTI4, Q5SVX7, Q5SVX9, Q60597, Q6PFZ2, Q80Y57, Q8K0K7, Q8K2Z3, Q8R3M2, Q91WP2
    Related
    ENSMUSP00000099090.3, ENSMUST00000101554.9
    Conserved Domains (1) summary
    PRK09404
    Location:491015
    sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
  4. NM_001252288.1NP_001239217.1  2-oxoglutarate dehydrogenase complex component E1 isoform 4

    See identical proteins and their annotated locations for NP_001239217.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR exon and lacks an in-frame coding exon, compared to variant 1. The resulting isoform (4) lacks an internal segment, compared to isoform 1. Variants 5 and 9 encode the same isoform (4).
    Source sequence(s)
    AK147289, AL607152, BC049104, BY782774, BY785860
    Consensus CDS
    CCDS56759.1
    UniProtKB/TrEMBL
    Z4YJV4
    Related
    ENSMUSP00000080569.5, ENSMUST00000081894.5
    Conserved Domains (1) summary
    PRK09404
    Location:491011
    sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
  5. NM_001361902.1NP_001348831.1  2-oxoglutarate dehydrogenase complex component E1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK147289, AL607152, BC049104, BC057354, BY125742
    Consensus CDS
    CCDS56758.1
    Conserved Domains (1) summary
    PRK09404
    Location:491026
    sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
  6. NM_001361903.1NP_001348832.1  2-oxoglutarate dehydrogenase complex component E1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK147289, AL607152, BC057354, CJ145669
    Consensus CDS
    CCDS56758.1
    Conserved Domains (1) summary
    PRK09404
    Location:491026
    sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
  7. NM_001361904.1NP_001348833.1  2-oxoglutarate dehydrogenase complex component E1 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AK147289, AL607152, BY768178, CK620645
    Consensus CDS
    CCDS36106.1
    UniProtKB/Swiss-Prot
    Q3UDM7, Q5DTI4, Q5SVX7, Q5SVX9, Q60597, Q6PFZ2, Q80Y57, Q8K0K7, Q8K2Z3, Q8R3M2, Q91WP2
    Conserved Domains (1) summary
    PRK09404
    Location:491015
    sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
  8. NM_001361905.1NP_001348834.1  2-oxoglutarate dehydrogenase complex component E1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AK147289, AL607152, BB842096, BC049104
    Consensus CDS
    CCDS56759.1
    UniProtKB/TrEMBL
    Z4YJV4
    Conserved Domains (1) summary
    PRK09404
    Location:491011
    sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
  9. NM_010956.4NP_035086.2  2-oxoglutarate dehydrogenase complex component E1 isoform 3 precursor

    See identical proteins and their annotated locations for NP_035086.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in a region of the coding sequence, compared to variant 1. The resulting isoform (3) has a shorter and different internal segment, compared to isoform 1. Variants 3 and 4 encode the same isoform 3.
    Source sequence(s)
    AK147289, AL607152
    Consensus CDS
    CCDS36106.1
    UniProtKB/Swiss-Prot
    Q3UDM7, Q5DTI4, Q5SVX7, Q5SVX9, Q60597, Q6PFZ2, Q80Y57, Q8K0K7, Q8K2Z3, Q8R3M2, Q91WP2
    Related
    ENSMUSP00000003461.9, ENSMUST00000003461.15
    Conserved Domains (1) summary
    PRK09404
    Location:491015
    sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    6241597..6309094
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245651.1XP_030101511.1  2-oxoglutarate dehydrogenase complex component E1 isoform X3

    UniProtKB/TrEMBL
    Z4YJV4
    Conserved Domains (1) summary
    PRK09404
    Location:491011
    sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
  2. XM_036156413.1XP_036012306.1  2-oxoglutarate dehydrogenase complex component E1 isoform X4

    Conserved Domains (1) summary
    PRK09404
    Location:3804
    sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
  3. XM_006514582.3XP_006514645.1  2-oxoglutarate dehydrogenase complex component E1 isoform X1

    See identical proteins and their annotated locations for XP_006514645.1

    UniProtKB/Swiss-Prot
    Q60597
    Conserved Domains (1) summary
    PRK09404
    Location:491026
    sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
  4. XM_030245650.1XP_030101510.1  2-oxoglutarate dehydrogenase complex component E1 isoform X3

    UniProtKB/TrEMBL
    Z4YJV4
    Conserved Domains (1) summary
    PRK09404
    Location:491011
    sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
  5. XM_030245649.2XP_030101509.1  2-oxoglutarate dehydrogenase complex component E1 isoform X2

    UniProtKB/Swiss-Prot
    Q3UDM7, Q5DTI4, Q5SVX7, Q5SVX9, Q60597, Q6PFZ2, Q80Y57, Q8K0K7, Q8K2Z3, Q8R3M2, Q91WP2
    Conserved Domains (1) summary
    PRK09404
    Location:491015
    sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
  6. XM_006514584.4XP_006514647.1  2-oxoglutarate dehydrogenase complex component E1 isoform X1

    See identical proteins and their annotated locations for XP_006514647.1

    UniProtKB/Swiss-Prot
    Q60597
    Conserved Domains (1) summary
    PRK09404
    Location:491026
    sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
  7. XM_030245652.1XP_030101512.1  2-oxoglutarate dehydrogenase complex component E1 isoform X3

    UniProtKB/TrEMBL
    Z4YJV4
    Conserved Domains (1) summary
    PRK09404
    Location:491011
    sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed
  8. XM_030245648.1XP_030101508.1  2-oxoglutarate dehydrogenase complex component E1 isoform X2

    UniProtKB/Swiss-Prot
    Q3UDM7, Q5DTI4, Q5SVX7, Q5SVX9, Q60597, Q6PFZ2, Q80Y57, Q8K0K7, Q8K2Z3, Q8R3M2, Q91WP2
    Conserved Domains (1) summary
    PRK09404
    Location:491015
    sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed