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NTRK2 neurotrophic receptor tyrosine kinase 2 [ Equus caballus (horse) ]

Gene ID: 100061700, updated on 11-Apr-2024

Summary

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Official Symbol
NTRK2provided by VGNC
Official Full Name
neurotrophic receptor tyrosine kinase 2provided by VGNC
Primary source
VGNC:VGNC:20927
See related
Ensembl:ENSECAG00000011815
Gene type
protein coding
RefSeq status
MODEL
Organism
Equus caballus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Orthologs
human mouse all
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Genomic context

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See NTRK2 in Genome Data Viewer
Location:
chromosome: 23
Exon count:
25
Annotation release Status Assembly Chr Location
103 current EquCab3.0 (GCF_002863925.1) 23 NC_009166.3 (5293165..5638376, complement)
102 previous assembly EquCab2.0 (GCF_000002305.2) 23 NC_009166.2 (5103383..5444150, complement)

Chromosome 23 - NC_009166.3Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111770135 Neighboring gene ATP/GTP binding carboxypeptidase 1 Neighboring gene microRNA mir-544b Neighboring gene uncharacterized LOC102150619 Neighboring gene uncharacterized LOC111770242

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables axon guidance receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables brain-derived neurotrophic factor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables brain-derived neurotrophic factor receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cell adhesion molecule binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cellular response to brain-derived neurotrophic factor stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in synapse organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in trans-synaptic signaling by neuropeptide, modulating synaptic transmission IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell-cell junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
BDNF/NT-3 growth factors receptor
Names
neurotrophic tyrosine receptor kinase type 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Equus caballus Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference EquCab3.0 Primary Assembly

Genomic

  1. NC_009166.3 Reference EquCab3.0 Primary Assembly

    Range
    5293165..5638376 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023627138.1 → XP_023482906.1  BDNF/NT-3 growth factors receptor isoform X2

    Conserved Domains (6) summary
    cd05093
    Location:536 → 823
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152 → 195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205 → 209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286 → 379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205 → 283
    Ig; Immunoglobulin domain

  2. XM_023627135.1 → XP_023482903.1  BDNF/NT-3 growth factors receptor isoform X1

    UniProtKB/TrEMBL
    F6QQD0
    Conserved Domains (6) summary
    cd05093
    Location:548 → 835
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152 → 195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205 → 209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286 → 379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205 → 283
    Ig; Immunoglobulin domain

  3. XM_023627136.1 → XP_023482904.1  BDNF/NT-3 growth factors receptor isoform X1

    UniProtKB/TrEMBL
    F6QQD0
    Conserved Domains (6) summary
    cd05093
    Location:548 → 835
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152 → 195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205 → 209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286 → 379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205 → 283
    Ig; Immunoglobulin domain

  4. XM_014735383.2 → XP_014590869.1  BDNF/NT-3 growth factors receptor isoform X3

    UniProtKB/TrEMBL
    F6QPZ0
    Conserved Domains (7) summary
    cd05855
    Location:301 → 379
    Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
    smart00408
    Location:210 → 273
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:204 → 283
    IG_like; Immunoglobulin like
    cd05093
    Location:532 → 819
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    pfam07714
    Location:538 → 807
    Pkinase_Tyr; Protein tyrosine kinase
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152 → 195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

  5. XM_023627134.1 → XP_023482902.1  BDNF/NT-3 growth factors receptor isoform X1

    UniProtKB/TrEMBL
    F6QQD0
    Conserved Domains (6) summary
    cd05093
    Location:548 → 835
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152 → 195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205 → 209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286 → 379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205 → 283
    Ig; Immunoglobulin domain

  6. XM_001496435.5 → XP_001496485.1  BDNF/NT-3 growth factors receptor isoform X3

    See identical proteins and their annotated locations for XP_001496485.1

    UniProtKB/TrEMBL
    F6QPZ0
    Related
    ENSECAP00000010154.1, ENSECAT00000012850.3
    Conserved Domains (7) summary
    cd05855
    Location:301 → 379
    Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
    smart00408
    Location:210 → 273
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:204 → 283
    IG_like; Immunoglobulin like
    cd05093
    Location:532 → 819
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    pfam07714
    Location:538 → 807
    Pkinase_Tyr; Protein tyrosine kinase
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152 → 195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

  7. XM_023627137.1 → XP_023482905.1  BDNF/NT-3 growth factors receptor isoform X1

    UniProtKB/TrEMBL
    F6QQD0
    Related
    ENSECAP00000030735.1, ENSECAT00000060271.3
    Conserved Domains (6) summary
    cd05093
    Location:548 → 835
    PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152 → 195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205 → 209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286 → 379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205 → 283
    Ig; Immunoglobulin domain

  8. XM_023627139.1 → XP_023482907.1  BDNF/NT-3 growth factors receptor isoform X4

    UniProtKB/TrEMBL
    A0A3Q2H315
    Related
    ENSECAP00000027960.2, ENSECAT00000038819.3
    Conserved Domains (7) summary
    sd00031
    Location:68 → 95
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:31 → 57
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152 → 195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205 → 209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286 → 379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205 → 283
    Ig; Immunoglobulin domain

  9. XM_003363989.4 → XP_003364037.1  BDNF/NT-3 growth factors receptor isoform X5

    See identical proteins and their annotated locations for XP_003364037.1

    Conserved Domains (7) summary
    cd05855
    Location:301 → 379
    Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
    smart00408
    Location:210 → 273
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:204 → 283
    IG_like; Immunoglobulin like
    sd00031
    Location:68 → 95
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:31 → 57
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152 → 195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

  10. XM_023627140.1 → XP_023482908.1  BDNF/NT-3 growth factors receptor isoform X6

    UniProtKB/TrEMBL
    A0A9L0TI65
    Conserved Domains (7) summary
    sd00031
    Location:68 → 95
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:31 → 57
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152 → 195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    cd00096
    Location:205 → 209
    Ig; Ig strand A' [structural motif]
    cd05855
    Location:286 → 379
    IgI_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:205 → 283
    Ig; Immunoglobulin domain

  11. XM_003363987.4 → XP_003364035.1  BDNF/NT-3 growth factors receptor isoform X7

    See identical proteins and their annotated locations for XP_003364035.1

    UniProtKB/TrEMBL
    A0A9L0SHU1, A0A9L0TI65
    Related
    ENSECAP00000074493.1, ENSECAT00000121908.1
    Conserved Domains (7) summary
    cd05855
    Location:301 → 379
    Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
    smart00408
    Location:210 → 273
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:204 → 283
    IG_like; Immunoglobulin like
    sd00031
    Location:68 → 95
    LRR_1; leucine-rich repeat [structural motif]
    pfam01462
    Location:31 → 57
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:92 → 150
    LRR_8; Leucine rich repeat
    pfam16920
    Location:152 → 195
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
Nucleotide Protein
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