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HNF4A hepatocyte nuclear factor 4 alpha [ Equus caballus (horse) ]

Gene ID: 100056007, updated on 8-Mar-2024

Summary

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Official Symbol
HNF4Aprovided by VGNC
Official Full Name
hepatocyte nuclear factor 4 alphaprovided by VGNC
Primary source
VGNC:VGNC:18819
See related
Ensembl:ENSECAG00000024450
Gene type
protein coding
RefSeq status
MODEL
Organism
Equus caballus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Orthologs
human mouse all
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Genomic context

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See HNF4A in Genome Data Viewer
Location:
chromosome: 22
Exon count:
10
Annotation release Status Assembly Chr Location
103 current EquCab3.0 (GCF_002863925.1) 22 NC_009165.3 (34525662..34552367)
102 previous assembly EquCab2.0 (GCF_000002305.2) 22 NC_009165.2 (33627201..33653935)

Chromosome 22 - NC_009165.3Genomic Context describing neighboring genes Neighboring gene R3H domain containing like Neighboring gene uncharacterized LOC106782409 Neighboring gene alpha tocopherol transfer protein like Neighboring gene serine incorporator 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear steroid receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in anatomical structure development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
hepatocyte nuclear factor 4-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Equus caballus Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference EquCab3.0 Primary Assembly

Genomic

  1. NC_009165.3 Reference EquCab3.0 Primary Assembly

    Range
    34525662..34552367
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_014735167.2 → XP_014590653.1  hepatocyte nuclear factor 4-alpha isoform X1

    UniProtKB/TrEMBL
    A0A5F5Q2X7
    Conserved Domains (2) summary
    cd06931
    Location:151 → 373
    NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
    cd06960
    Location:60 → 135
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers

  2. XM_014735168.2 → XP_014590654.1  hepatocyte nuclear factor 4-alpha isoform X3

    UniProtKB/TrEMBL
    A0A5F5Q2X7
    Conserved Domains (2) summary
    cd06931
    Location:151 → 373
    NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
    cd06960
    Location:60 → 135
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers

  3. XM_001502993.6 → XP_001503043.1  hepatocyte nuclear factor 4-alpha isoform X2

    See identical proteins and their annotated locations for XP_001503043.1

    UniProtKB/TrEMBL
    A0A5F5PJZ1
    Related
    ENSECAP00000048870.1, ENSECAT00000073545.2
    Conserved Domains (2) summary
    cd06931
    Location:151 → 373
    NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
    cd06960
    Location:60 → 135
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers

  4. XM_003363931.4 → XP_003363979.1  hepatocyte nuclear factor 4-alpha isoform X4

    See identical proteins and their annotated locations for XP_003363979.1

    UniProtKB/TrEMBL
    A0A5F5Q2X7
    Conserved Domains (2) summary
    cd06931
    Location:151 → 373
    NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
    cd06960
    Location:60 → 135
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
Nucleotide Protein
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