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HNF4A hepatocyte nuclear factor 4 alpha [ Homo sapiens (human) ]

Gene ID: 3172, updated on 10-Oct-2024

Summary

Official Symbol
HNF4Aprovided by HGNC
Official Full Name
hepatocyte nuclear factor 4 alphaprovided by HGNC
Primary source
HGNC:HGNC:5024
See related
Ensembl:ENSG00000101076 MIM:600281; AllianceGenome:HGNC:5024
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TCF; HNF4; MODY; FRTS4; MODY1; NR2A1; TCF14; HNF4a7; HNF4a8; HNF4a9; NR2A21; TCF-14; HNF4alpha
Summary
The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012]
Expression
Biased expression in duodenum (RPKM 37.7), colon (RPKM 32.8) and 7 other tissues See more
Orthologs
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Genomic context

See HNF4A in Genome Data Viewer
Location:
20q13.12
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (44355699..44434596)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (46090439..46170188)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (42984339..43063236)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:42938689-42939418 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:42939419-42940148 Neighboring gene fat storage inducing transmembrane protein 2 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:42952746-42953298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:42962599-42963110 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:42964365-42965354 Neighboring gene R3H domain containing like Neighboring gene R3HDML antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:42981671-42982170 Neighboring gene HNF4A antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17923 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:43017550-43018051 Neighboring gene microRNA 3646 Neighboring gene long intergenic non-protein coding RNA 1430 Neighboring gene long intergenic non-protein coding RNA 1620

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Biological, clinical and population relevance of 95 loci for blood lipids.
EBI GWAS Catalog
Common variants at 30 loci contribute to polygenic dyslipidemia.
EBI GWAS Catalog
Discovery and refinement of loci associated with lipid levels.
EBI GWAS Catalog
Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.
EBI GWAS Catalog
Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci.
EBI GWAS Catalog
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.
EBI GWAS Catalog
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
EBI GWAS Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ39654

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
 
enables fatty acid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nuclear receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables signaling receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in blood coagulation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cholesterol homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in intracellular receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phospholipid homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of gastrulation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of growth hormone receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of insulin secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of lipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of ornithine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to glucose ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in rhythmic process IEA
Inferred from Electronic Annotation
more info
 
involved_in sex differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction involved in regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in triglyceride homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in xenobiotic metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
hepatocyte nuclear factor 4-alpha
Names
HNF4A wild type
HNF4alpha10/11/12
hepatic nuclear factor 4 alpha
nuclear receptor subfamily 2 group A member 1
transcription factor 14
transcription factor HNF-4

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009818.1 RefSeqGene

    Range
    5001..82045
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_483

mRNA and Protein(s)

  1. NM_000457.6NP_000448.3  hepatocyte nuclear factor 4-alpha isoform 2

    See identical proteins and their annotated locations for NP_000448.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes the longest isoform (2, also known as HNF4alpha2).
    Source sequence(s)
    AL132772
    Consensus CDS
    CCDS13330.1
    UniProtKB/Swiss-Prot
    A5JW41, B2RPP8, O00659, O00723, P41235, Q14540, Q5QPB8, Q6B4V5, Q6B4V6, Q6B4V7, Q92653, Q92654, Q92655, Q99864, Q9NQH0
    UniProtKB/TrEMBL
    B6ZGT3, F1D8T1
    Related
    ENSP00000312987.3, ENST00000316099.10
    Conserved Domains (2) summary
    cd06931
    Location:151373
    NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
    cd06960
    Location:60135
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
  2. NM_001030003.3NP_001025174.1  hepatocyte nuclear factor 4-alpha isoform 4

    See identical proteins and their annotated locations for NP_001025174.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' terminal exon (resulting in translation initiation from an alternate upstream start codon) and uses an alternate in-frame donor splice site in the 3' coding region compared to variant 2. The resulting shorter isoform (4, also known as HNF4alpha7) has a distinct N-terminus and lacks a 10 aa protein segment in the C-terminal region compared to isoform 2.
    Source sequence(s)
    AL117382, AL132772, AW134564, AY680696
    Consensus CDS
    CCDS46604.1
    UniProtKB/TrEMBL
    B6ZGT3
    Related
    ENSP00000396216.1, ENST00000457232.5
    Conserved Domains (2) summary
    cd06931
    Location:129351
    NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
    cd06960
    Location:38113
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
  3. NM_001030004.3NP_001025175.1  hepatocyte nuclear factor 4-alpha isoform 6

    See identical proteins and their annotated locations for NP_001025175.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) contains an alternate 5' terminal exon (resulting in translation initiation from an alternate upstream start codon) and differs at the 3' end that causes a frame-shift compared to variant 2. The resulting shorter isoform (6, also known as HNF4alpha9) has distinct N- and C-termini compared to isoform 2.
    Source sequence(s)
    AL117382, AL132772, AY680698
    Consensus CDS
    CCDS68131.1
    UniProtKB/TrEMBL
    A0A087WXV4
    Related
    ENSP00000476609.1, ENST00000609795.5
    Conserved Domains (2) summary
    cd06931
    Location:129351
    NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
    cd06960
    Location:38113
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
  4. NM_001258355.2NP_001245284.1  hepatocyte nuclear factor 4-alpha isoform 7

    See identical proteins and their annotated locations for NP_001245284.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) contains an additional coding exon in the 5' region that results in translation initiation from an alternate downstream start codon compared to variant 2. The resulting shorter isoform (7) has a distinct N-terminus compared to isoform 2.
    Source sequence(s)
    AL132772, AW134564, BP274413, HQ692869, Z49825
    UniProtKB/TrEMBL
    B6ZGT3
    Conserved Domains (2) summary
    cd06931
    Location:144366
    NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
    cd06960
    Location:53128
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
  5. NM_001287182.2NP_001274111.1  hepatocyte nuclear factor 4-alpha isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs at the 5' end (resulting in translation initiation from an alternate upstream start codon) and uses an alternate in-frame donor splice site in the 3' coding region compared to variant 2. The resulting shorter isoform (8, also known as HNF4alpha10) has a distinct N-terminus and lacks a 10 aa protein segment in the C-terminal region compared to isoform 2.
    Source sequence(s)
    AL117382, AL132772, AW134564, AY680696, FJ608822
    UniProtKB/TrEMBL
    B6ZGT3
    Conserved Domains (2) summary
    cd06931
    Location:126348
    NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
    cd06960
    Location:35110
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
  6. NM_001287183.2NP_001274112.1  hepatocyte nuclear factor 4-alpha isoform 9

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs at the 5' end, which results in translation initiation from an alternate upstream start codon compared to variant 2. The resulting shorter isoform (9, also known as HNF4alpha11) has a distinct N-terminus compared to isoform 2.
    Source sequence(s)
    AL117382, AL132772
    UniProtKB/TrEMBL
    B6ZGT3
    Conserved Domains (2) summary
    cd06931
    Location:126348
    NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
    cd06960
    Location:35110
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
  7. NM_001287184.2NP_001274113.1  hepatocyte nuclear factor 4-alpha isoform 10

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs at the 5' end (resulting in translation initiation from an alternate upstream start codon) and at the 3' end (that causes a frame-shift) compared to variant 2. The resulting shorter isoform (10, also known as HNF4alpha12) has distinct N- and C-termini compared to isoform 2.
    Source sequence(s)
    AL117382, AL132772, AY680698, BC137539, FJ608822
    UniProtKB/TrEMBL
    A0A087WXV4
    Conserved Domains (2) summary
    cd06931
    Location:126348
    NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
    cd06960
    Location:35110
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
  8. NM_175914.5NP_787110.2  hepatocyte nuclear factor 4-alpha isoform 5

    See identical proteins and their annotated locations for NP_787110.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate 5' terminal exon, which results in translation initiation from an alternate upstream start codon compared to variant 2. The resulting shorter isoform (5, also known as HNF4alpha8) has a distinct N-terminus compared to isoform 2.
    Source sequence(s)
    AL117382, AL132772
    Consensus CDS
    CCDS42876.1
    UniProtKB/TrEMBL
    B6ZGT3, F1D8T0
    Related
    ENSP00000315180.4, ENST00000316673.9
    Conserved Domains (2) summary
    cd06931
    Location:129351
    NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
    cd06960
    Location:38113
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
  9. NM_178849.3NP_849180.1  hepatocyte nuclear factor 4-alpha isoform 1

    See identical proteins and their annotated locations for NP_849180.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame donor splice site in the 3' coding region compared to variant 2. The resulting shorter isoform (1, also known as HNF4alpha1) lacks a 10 aa protein segment compared to isoform 2.
    Source sequence(s)
    AL132772, AW134564, BP274413, HQ692860
    Consensus CDS
    CCDS46605.1
    UniProtKB/TrEMBL
    B6ZGT3, F1D8S2
    Related
    ENSP00000412111.1, ENST00000415691.2
    Conserved Domains (2) summary
    cd06931
    Location:151373
    NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
    cd06960
    Location:60135
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
  10. NM_178850.3NP_849181.1  hepatocyte nuclear factor 4-alpha isoform 3

    See identical proteins and their annotated locations for NP_849181.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has a different 3' end that causes a frame-shift compared to variant 2. The resulting shorter isoform (3, also known as HNF4alpha3) has a distinct C-terminus compared to isoform 2.
    Source sequence(s)
    AL132772, BC137539, BP274413
    Consensus CDS
    CCDS13331.1
    UniProtKB/TrEMBL
    A0A087WXV4
    Related
    ENSP00000410911.2, ENST00000443598.6
    Conserved Domains (2) summary
    cd06931
    Location:151373
    NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
    cd06960
    Location:60135
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    44355699..44434596
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047440138.1XP_047296094.1  hepatocyte nuclear factor 4-alpha isoform X2

    UniProtKB/TrEMBL
    F1D8S2
  2. XM_047440135.1XP_047296091.1  hepatocyte nuclear factor 4-alpha isoform X1

    UniProtKB/Swiss-Prot
    A5JW41, B2RPP8, O00659, O00723, P41235, Q14540, Q5QPB8, Q6B4V5, Q6B4V6, Q6B4V7, Q92653, Q92654, Q92655, Q99864, Q9NQH0
    UniProtKB/TrEMBL
    F1D8T1
  3. XM_047440136.1XP_047296092.1  hepatocyte nuclear factor 4-alpha isoform X1

    UniProtKB/Swiss-Prot
    A5JW41, B2RPP8, O00659, O00723, P41235, Q14540, Q5QPB8, Q6B4V5, Q6B4V6, Q6B4V7, Q92653, Q92654, Q92655, Q99864, Q9NQH0
    UniProtKB/TrEMBL
    F1D8T1
  4. XM_047440137.1XP_047296093.1  hepatocyte nuclear factor 4-alpha isoform X1

    UniProtKB/Swiss-Prot
    A5JW41, B2RPP8, O00659, O00723, P41235, Q14540, Q5QPB8, Q6B4V5, Q6B4V6, Q6B4V7, Q92653, Q92654, Q92655, Q99864, Q9NQH0
    UniProtKB/TrEMBL
    F1D8T1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    46090439..46170188
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054323403.1XP_054179378.1  hepatocyte nuclear factor 4-alpha isoform X1

    UniProtKB/Swiss-Prot
    A5JW41, B2RPP8, O00659, O00723, P41235, Q14540, Q5QPB8, Q6B4V5, Q6B4V6, Q6B4V7, Q92653, Q92654, Q92655, Q99864, Q9NQH0
    UniProtKB/TrEMBL
    F1D8T1
  2. XM_054323402.1XP_054179377.1  hepatocyte nuclear factor 4-alpha isoform X1

    UniProtKB/Swiss-Prot
    A5JW41, B2RPP8, O00659, O00723, P41235, Q14540, Q5QPB8, Q6B4V5, Q6B4V6, Q6B4V7, Q92653, Q92654, Q92655, Q99864, Q9NQH0
    UniProtKB/TrEMBL
    F1D8T1
  3. XM_054323405.1XP_054179380.1  hepatocyte nuclear factor 4-alpha isoform X2

    UniProtKB/TrEMBL
    F1D8S2
  4. XM_054323404.1XP_054179379.1  hepatocyte nuclear factor 4-alpha isoform X1

    UniProtKB/Swiss-Prot
    A5JW41, B2RPP8, O00659, O00723, P41235, Q14540, Q5QPB8, Q6B4V5, Q6B4V6, Q6B4V7, Q92653, Q92654, Q92655, Q99864, Q9NQH0
    UniProtKB/TrEMBL
    F1D8T1