BCL2L1 BCL2 like 1 [Oryctolagus cuniculus (rabbit)] - Gene

Summary

Gene symbol: BCL2L1
Gene description: BCL2 like 1
See related: Ensembl:ENSOCUG00000003201
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Oryctolagus cuniculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_02	current	UM_NZW_1.0 (GCF_009806435.1)	4	NC_067377.1 (15157462..15215700)

Chromosome 4 - NC_067377.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_067377.1 Chromosome 4 Reference UM_NZW_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study leads to conclude that BCLXL peak expression at the zygotic genome activation phase may be a requirement for embryo development
Title: Candidate gene expression patterns in rabbit preimplantation embryos developed in vivo and in vitro.
In this study evidence is provided that exogenous PGF2alpha differentially modulates luteal expression of BCL2L1 transcripts and protein depending on luteal stage.
Title: Expression of luteal estrogen receptor, interleukin-1, and apoptosis-associated genes after PGF2alpha administration in rabbits at different stages of pseudopregnancy.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in extrinsic apoptotic signaling pathway in absence of ligand	IEA Inferred from Electronic Annotation more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: bcl-2-like protein 1

Names: Bcl-X

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001082135.1 → NP_001075604.1 bcl-2-like protein 1

See identical proteins and their annotated locations for NP_001075604.1

Status: PROVISIONAL

Source sequence(s)

AY005131

UniProtKB/TrEMBL

Q9MYW4

Conserved Domains (3) summary

smart00265
Location:1 → 27

BH4; BH4 Bcl-2 homology region 4

cd06845
Location:81 → 194

Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...

TIGR00865
Location:1 → 233

bcl-2; apoptosis regulator

RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UM_NZW_1.0 Primary Assembly

Genomic

NC_067377.1 Reference UM_NZW_1.0 Primary Assembly

Range

15157462..15215700

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008256139.3 → XP_008254361.1 bcl-2-like protein 1 isoform X1

See identical proteins and their annotated locations for XP_008254361.1

UniProtKB/TrEMBL

Q9MYW4

Conserved Domains (3) summary

smart00265
Location:1 → 27

BH4; BH4 Bcl-2 homology region 4

cd06845
Location:81 → 194

Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...

TIGR00865
Location:1 → 233

bcl-2; apoptosis regulator
XM_008256140.3 → XP_008254362.1 bcl-2-like protein 1 isoform X1

See identical proteins and their annotated locations for XP_008254362.1

UniProtKB/TrEMBL

Q9MYW4

Conserved Domains (3) summary

smart00265
Location:1 → 27

BH4; BH4 Bcl-2 homology region 4

cd06845
Location:81 → 194

Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...

TIGR00865
Location:1 → 233

bcl-2; apoptosis regulator
XM_008256137.3 → XP_008254359.1 bcl-2-like protein 1 isoform X1

See identical proteins and their annotated locations for XP_008254359.1

UniProtKB/TrEMBL

Q9MYW4

Related

ENSOCUP00000002775.2

Conserved Domains (3) summary

smart00265
Location:1 → 27

BH4; BH4 Bcl-2 homology region 4

cd06845
Location:81 → 194

Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...

TIGR00865
Location:1 → 233

bcl-2; apoptosis regulator
XM_008256138.3 → XP_008254360.1 bcl-2-like protein 1 isoform X1

See identical proteins and their annotated locations for XP_008254360.1

UniProtKB/TrEMBL

Q9MYW4

Conserved Domains (3) summary

smart00265
Location:1 → 27

BH4; BH4 Bcl-2 homology region 4

cd06845
Location:81 → 194

Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...

TIGR00865
Location:1 → 233

bcl-2; apoptosis regulator
XM_008256141.3 → XP_008254363.1 bcl-2-like protein 1 isoform X1

See identical proteins and their annotated locations for XP_008254363.1

UniProtKB/TrEMBL

Q9MYW4

Conserved Domains (3) summary

smart00265
Location:1 → 27

BH4; BH4 Bcl-2 homology region 4

cd06845
Location:81 → 194

Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...

TIGR00865
Location:1 → 233

bcl-2; apoptosis regulator