Literature
PubMed
PubMed® comprises more than 36 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full text content from PubMed Central and publisher web sites.
Literature databases
Books and reports
Ontology used for PubMed indexing
Books, journals and more in the NLM Collections
Scientific and medical abstracts/citations
Full-text journal articles
Data
Genes
Gene sequences and annotations used as references for the study of orthologs structure, expression, and evolution
Collected information about gene loci
Functional genomics studies
Gene expression and molecular abundance profiles
Homologous genes sets for selected organisms
Sequence sets from phylogenetic and population studies
Proteins
Protein sequences, 3-D structures, and tools for the study of functional protein domains and active sites
Conserved protein domains
Protein sequences grouped by identity
Protein sequences
Models representing homologous proteins with a common function
Experimentally-determined biomolecular structures
BLAST
A tool to find regions of similarity between biological sequences
Search nucleotide sequence databases
Search protein sequence databases
Search protein databases using a translated nucleotide query
Search translated nucleotide databases using a protein query
Find primers specific to your PCR template
Genomes
Genome sequence assemblies, large-scale functional genomics data, and source biological samples
Genome assembly information
Museum, herbaria, and other biorepository collections
Biological projects providing data to NCBI
Descriptions of biological source materials
Genome sequencing projects by organism
DNA and RNA sequences
High-throughput sequence reads
Taxonomic classification and nomenclature
Clinical
Heritable DNA variations, associations with human pathologies, and clinical diagnostics and treatments
Privately and publicly funded clinical studies conducted around the world
Human variations of clinical significance
Genotype/phenotype interaction studies
Short genetic variations
Genome structural variation studies
Genetic testing registry
Medical genetics literature and links
Online mendelian inheritance in man
PubChem
Repository of chemical information, molecular pathways, and tools for bioactivity screening
Bioactivity screening studies
Chemical information with structures, information and links
Molecular pathways with links to genes, proteins and chemicals
Deposited substance and chemical information
News
Research news
NIH study shows higher mortality rates for patients on respiratory support in rural intermediate care units
Findings highlight the importance of providing ICU-level care to rural patients with respiratory failure
Zero Gravity, Zero Gain: The Genetics Behind Muscle Loss in Space
Simulated microgravity in mice reveals a constellation of genes that may influence muscle weakening during spaceflight.
Coronavirus FAQ: How long does my post-COVID protection last? When is it booster time?
How long does immunity last after an infection? Are rapid tests always accurate? How often is a booster in order? In this installment of our FAQ series, we look into questions about "COVID time."
Recent blog posts
Findings in Tuberculosis Immunity Point Toward New Approaches to Treatment and Prevention
Tuberculosis, caused by the bacteria Mycobacterium tuberculosis (Mtb), took 1.3 million lives in 2022, making it the second leading infectious killer around the world after COVID-19. Current TB treatments require months of daily medicine and certain cases of TB are becoming increasingly difficult to treat because of drug resistance. While TB case counts had been steadily decreasing before the COVID-19 pandemic, in the last couple of years there’s been an uptick. Although a TB vaccine exists and offers some protection to young children, the vaccine, known as BCG, has not effectively prevented TB in adults. Developing more protective and longer lasting TB vaccines remains an urgent priority for NIH. As part of this effort, NIH Immune Mechanisms of Protection Against Mycobacterium tuberculosis Centers (IMPAc-TB) are working to learn more about how we can harness our immune systems to mount the best protection against Mtb. And I’m happy to share some encouraging results now reported in the journal PLoS Pathogens, which show progress in understanding TB immunity and suggest additional strategies to fight this deadly bacterial infection in the future.
Enhancements to ClinVar Website Now Live
As previously announced, we updated the ClinVar website as part of our effort to better support the display of submitted somatic variation data. What changed? Updated ClinVar search results Germline / Somatic origin filter Somatic Classification and Review Status summary Updated Variant (VCV) record page Includes both Germline and Somatic data for the same variant … Continue reading Enhancements to ClinVar Website Now Live
HomoloGene Now Redirects to NCBI Datasets Gene
A new way to view and download related genes As previously announced, HomoloGene now automatically redirects to the NCBI Datasets Gene page giving you easy access to up-to-date sequence and homology data. The NCBI Datasets Gene Table provides a link to NCBI Orthologs with expanded gene and protein information and links to tools. NCBI Orthologs … Continue reading HomoloGene Now Redirects to NCBI Datasets Gene