Literature
PubMed
PubMed® comprises more than 37 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full text content from PubMed Central and publisher web sites.
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Literature databases
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Ontology used for PubMed indexing
Books, journals and more in the NLM Collections
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Data
Genes
Gene sequences and annotations used as references for the study of orthologs structure, expression, and evolution
Collected information about gene loci
Functional genomics studies
Gene expression and molecular abundance profiles
Sequence sets from phylogenetic and population studies
Proteins
Protein sequences, 3-D structures, and tools for the study of functional protein domains and active sites
Conserved protein domains
Protein sequences grouped by identity
Protein sequences
Models representing homologous proteins with a common function
Experimentally-determined biomolecular structures
BLAST
A tool to find regions of similarity between biological sequences
Search nucleotide sequence databases
Search protein sequence databases
Search protein databases using a translated nucleotide query
Search translated nucleotide databases using a protein query
Find primers specific to your PCR template
Genomes
Genome sequence assemblies, large-scale functional genomics data, and source biological samples
Genome assembly information
Museum, herbaria, and other biorepository collections
Biological projects providing data to NCBI
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Genome sequencing projects by organism
DNA and RNA sequences
High-throughput sequence reads
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Clinical
Heritable DNA variations, associations with human pathologies, and clinical diagnostics and treatments
Privately and publicly funded clinical studies conducted around the world
Human variations of clinical significance
Genotype/phenotype interaction studies
Short genetic variations
Genome structural variation studies
Genetic testing registry
Medical genetics literature and links
Online mendelian inheritance in man
PubChem
Repository of chemical information, molecular pathways, and tools for bioactivity screening
Bioactivity screening studies
Chemical information with structures, information and links
Molecular pathways with links to genes, proteins and chemicals
Deposited substance and chemical information
News
Research news
What chimpanzee gestures reveal about human communication : Short Wave
Chimpanzees are humans' closest living relatives. But does much of their communication resembles ours? According to a new study published earlier this week in the journal Current Biology, chimpanzees gesture back-and-forth in a similar way to how humans take turns speaking. The research presents an intriguing possibility that …
A study finds that dogs can smell your stress — and make decisions accordingly
Researchers made volunteers do public speaking and math on the spot, then showed them a calming video. Then, using sweat samples, glass jars and food bowls, they examined the emotional impact on dogs.
When did humans get to South America? This giant shelled mammal fossil may hold clues
A fossil of an armadillo-like mammal appears to bear cut marks from butchering by humans, suggesting people were living in South America at least 20,000 years ago, even earlier than once thought.
Recent blog posts
Epigenetic Editor Silences Toxic Proteins in the Mouse Brain, Offering Promising Path to Treat Deadly Prion Diseases
Prion diseases are fatal neurodegenerative disorders caused by a malfunction of the prion protein in the brain. Exposure to a misfolded version of the protein triggers normal proteins of the same type in the brain to misfold, forming clumps that produce infectious disease and fatal brain damage over time. There are currently no treatments, preventive vaccines, or cures for prion diseases, which can be acquired, like mad cow disease, or inherited, like fatal familial insomnia. But an encouraging new study in mice suggests a potentially promising path for developing a treatment for people with these deadly conditions. Findings from an NIH-supported study reported in Science show that the key to this approach is a molecular tool capable of silencing prion protein throughout the brain using epigenetic editing. Unlike gene editing approaches, which change the sequence of genes, epigenetic editing can turn gene expression off with the addition of a chemical tag that prevents genes from being translated into proteins. Such a strategy may be able to deliver modifying tools to the brain or other parts of the body to silence specific toxic or disease-causing genes, including the one encoding the prion protein, without the risks associated with altering DNA sequences.
Fostering the Researchers of Tomorrow: The NLM Data Science and Informatics Scholars Program
This summer’s NLM Data Science and Informatics Scholars Program welcomes its largest cohort of interns who are collaborating on innovative research in bioinformatics, data analytics, and more. Learn how they’re shaping the future of biomedical research and how NLM can accelerate your own career!
Open Access! Million Veteran Program Genome-Wide PheWAS Results Now Available in dbGaP!
The Million Veteran Program (MVP) is a research program from the U.S. Department of Veterans Affairs (VA) that has collected and analyzed health information from over one million veteran volunteers. The data include genes, lifestyles, military experiences, and exposures that may impact health and wellness. The results of the MVP phenome-wide association study (PheWAS) … Continue reading Open Access! Million Veteran Program Genome-Wide PheWAS Results Now Available in dbGaP!