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Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet]. York (UK): Centre for Reviews and Dissemination (UK); 1995-.
Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet].
Show detailsBibliographic details: Pouwer F, Nijpels G, Beekman A T, Dekker J M, van Dam R M, Heine R J, Snoek F J. Fat food for a bad mood. Could we treat and prevent depression in Type 2 diabetes by means of omega-3 polyunsaturated fatty acids: a review of the evidence. Diabetic Medicine 2005; 22(11): 1465-1475. [PubMed: 16241908]
Abstract
AIMS: Evidence strongly suggests that depression is a common complication of Type 2 diabetes mellitus. However, there is considerable room to improve the effectiveness of pharmacological antidepressant agents, as in only 50-60% of the depressed subjects with diabetes does pharmacotherapy lead to remission of depression. The aim of the present paper was to review whether polyunsaturated fatty acids (PUFA) of the omega-3 family could be used for the prevention and treatment of depression in Type 2 diabetes.
METHODS: MEDLINE database and published reference lists were used to identify studies that examined the associations between omega-3 PUFA and depression. To examine potential side-effects, such as on glycaemic control, studies regarding the use of omega-3 supplements in Type 2 diabetes were also reviewed.
RESULTS: Epidemiological and clinical studies suggest that a high intake of omega-3 PUFA protects against the development of depression. There is also some evidence that a low intake of omega-3 is associated with an increased risk of Type 2 diabetes, but the results are less conclusive. Results from randomized controlled trials in non-diabetic subjects with major depression show that eicosapentaenoic acid is an effective adjunct treatment of depression in diabetes, while docosahexanoic acid is not. Moreover, consumption of omega-3 PUFA reduces the risk of cardiovascular disease and may therefore indirectly decrease depression in Type 2 diabetes, via the reduction of cardiovascular complications.
CONCLUSIONS: Supplementation with omega-3 PUFA, in particular eicosapentaenoic acid, may be a safe and helpful tool to reduce the incidence of depression and to treat depression in Type 2 diabetes. Further studies are now justified to test these hypotheses in patients with Type 2 diabetes.
- Structured dietary advice incorporating walnuts achieves optimal fat and energy balance in patients with type 2 diabetes mellitus.[J Am Diet Assoc. 2005]Structured dietary advice incorporating walnuts achieves optimal fat and energy balance in patients with type 2 diabetes mellitus.Gillen LJ, Tapsell LC, Patch CS, Owen A, Batterham M. J Am Diet Assoc. 2005 Jul; 105(7):1087-96.
- Review Omega-3 polyunsaturated fatty acids and depression: a review of the evidence and a methodological critique.[Prev Med. 2006]Review Omega-3 polyunsaturated fatty acids and depression: a review of the evidence and a methodological critique.Sontrop J, Campbell MK. Prev Med. 2006 Jan; 42(1):4-13. Epub 2005 Dec 7.
- Review The role of omega-3 fatty acids in mood disorders.[Curr Opin Investig Drugs. 2008]Review The role of omega-3 fatty acids in mood disorders.Stahl LA, Begg DP, Weisinger RS, Sinclair AJ. Curr Opin Investig Drugs. 2008 Jan; 9(1):57-64.
- Highly purified omega-3 polyunsaturated fatty acids are effective as adjunct therapy for secondary prevention of myocardial infarction.[Herz. 2006]Highly purified omega-3 polyunsaturated fatty acids are effective as adjunct therapy for secondary prevention of myocardial infarction.Verboom CN, Critical Analysis of GISSI-Prevenzione Trial. Herz. 2006 Dec; 31 Suppl 3:49-59.
- Omega-3 fatty acid deficiency in major depressive disorder is caused by the interaction between diet and a genetically determined abnormality in phospholipid metabolism.[Med Hypotheses. 2007]Omega-3 fatty acid deficiency in major depressive disorder is caused by the interaction between diet and a genetically determined abnormality in phospholipid metabolism.Ross BM. Med Hypotheses. 2007; 68(3):515-24. Epub 2006 Oct 12.
- Fat food for a bad mood. Could we treat and prevent depression in Type 2 diabete...Fat food for a bad mood. Could we treat and prevent depression in Type 2 diabetes by means of omega-3 polyunsaturated fatty acids: a review of the evidence - Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews
- ras GTPase-activating protein-binding protein 2 [Tribolium castaneum]ras GTPase-activating protein-binding protein 2 [Tribolium castaneum]gi|91076984|ref|XP_975463.1|Protein
- 1-deoxy-D-xylulose 5-phosphate reductoisomerase [Escherichia coli str. K-12 subs...1-deoxy-D-xylulose 5-phosphate reductoisomerase [Escherichia coli str. K-12 substr. MG1655]gi|16128166|gnl|REF_b0173|NP_414715 NP_414715.1|Protein
- protein ENL [Homo sapiens]protein ENL [Homo sapiens]gi|21361272|ref|NP_005925.2|Protein
- hypothetical protein RirG_240650 [Rhizophagus irregularis DAOM 197198w]hypothetical protein RirG_240650 [Rhizophagus irregularis DAOM 197198w]gi|595441343|gb|EXX53789.1||gnl|WGS |RirT_240650Protein
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