Amino Acid Substitution

The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.

Year introduced: 1998

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Tree Number(s): E05.393.420.601.035, G05.558.109

MeSH Unique ID: D019943

Entry Terms:

• Amino Acid Substitutions
• Substitution, Amino Acid
• Substitutions, Amino Acid

Previous Indexing:

• Amino Acid Sequence (1966-1997)

See Also:

• Mutagenesis, Site-Directed
• Mutation, Missense

All MeSH Categories
Analytical, Diagnostic and Therapeutic Techniques and Equipment Category
Investigative Techniques
Genetic Techniques
Genetic Engineering
Protein Engineering
Amino Acid Substitution

All MeSH Categories
Phenomena and Processes Category
Genetic Phenomena
Mutagenesis
Amino Acid Substitution