Protein Engineering

Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes.

Year introduced: 1989

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Tree Number(s): E05.393.420.601

MeSH Unique ID: D015202

Entry Terms:

• Engineering, Protein
• Genetic Engineering of Proteins
• Genetic Engineering, Protein
• Engineering, Protein Genetic
• Protein Genetic Engineering
• Proteins, Genetic Engineering

Previous Indexing:

• Genes, Structural (1983-1988)
• Genetic Intervention (1983-1988)
• Mutation (1983-1988)

See Also:

• Mutagenesis, Site-Directed
• Directed Molecular Evolution

All MeSH Categories
Analytical, Diagnostic and Therapeutic Techniques and Equipment Category
Investigative Techniques
Genetic Techniques
Genetic Engineering
Protein Engineering
Amino Acid Substitution
Cell Surface Display Techniques
Mutagenesis, Insertional
Mutagenesis, Site-Directed
Targeted Gene Repair