U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Drug-induced liver injury

MedGen UID:
163652
Concept ID:
C0860207
Disease or Syndrome
Synonyms: Disease, Drug-Induced Liver; Diseases, Drug-Induced Liver; Drug Induced Liver Disease; Drug Induced Liver Injury; Drug-Induced Liver Disease; Drug-Induced Liver Diseases; Drug-Induced Liver Injuries; Drug-Induced Liver Injury; Injuries, Drug-Induced Liver; Injury, Drug-Induced Liver; Liver Disease, Drug-Induced; Liver Diseases, Drug-Induced; Liver Injuries, Drug-Induced; Liver Injury, Drug Induced; Liver Injury, Drug-Induced
SNOMED CT: Drug-induced disorder of liver (427399008); Drug induced hepatotoxicity (427399008)
 
Monarch Initiative: MONDO:0005359

Definition

Damage to the liver tissue due to drug overdose. [from NCI]

Professional guidelines

PubMed

Björnsson HK, Björnsson ES
Eur J Intern Med 2022 Mar;97:26-31. Epub 2021 Nov 9 doi: 10.1016/j.ejim.2021.10.035. PMID: 34772600
European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; Clinical Practice Guideline Panel: Chair:; Panel members; EASL Governing Board representative:
J Hepatol 2019 Jun;70(6):1222-1261. Epub 2019 Mar 27 doi: 10.1016/j.jhep.2019.02.014. PMID: 30926241
Mansour D, McPherson S
Clin Med (Lond) 2018 Apr 1;18(Suppl 2):s60-s65. doi: 10.7861/clinmedicine.18-2-s60. PMID: 29700095Free PMC Article

Recent clinical studies

Etiology

Li X, Tang J, Mao Y
Liver Int 2022 Aug;42(9):1999-2014. Epub 2022 Apr 2 doi: 10.1111/liv.15262. PMID: 35353431
Björnsson HK, Björnsson ES
Eur J Intern Med 2022 Mar;97:26-31. Epub 2021 Nov 9 doi: 10.1016/j.ejim.2021.10.035. PMID: 34772600
Andrade RJ, Chalasani N, Björnsson ES, Suzuki A, Kullak-Ublick GA, Watkins PB, Devarbhavi H, Merz M, Lucena MI, Kaplowitz N, Aithal GP
Nat Rev Dis Primers 2019 Aug 22;5(1):58. doi: 10.1038/s41572-019-0105-0. PMID: 31439850
European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; Clinical Practice Guideline Panel: Chair:; Panel members; EASL Governing Board representative:
J Hepatol 2019 Jun;70(6):1222-1261. Epub 2019 Mar 27 doi: 10.1016/j.jhep.2019.02.014. PMID: 30926241
Katarey D, Verma S
Clin Med (Lond) 2016 Dec;16(Suppl 6):s104-s109. doi: 10.7861/clinmedicine.16-6-s104. PMID: 27956449Free PMC Article

Diagnosis

Tan CK, Ho D, Wang LM, Kumar R
World J Gastroenterol 2022 Jun 28;28(24):2654-2666. doi: 10.3748/wjg.v28.i24.2654. PMID: 35979160Free PMC Article
Björnsson HK, Björnsson ES
Eur J Intern Med 2022 Mar;97:26-31. Epub 2021 Nov 9 doi: 10.1016/j.ejim.2021.10.035. PMID: 34772600
Andrade RJ, Chalasani N, Björnsson ES, Suzuki A, Kullak-Ublick GA, Watkins PB, Devarbhavi H, Merz M, Lucena MI, Kaplowitz N, Aithal GP
Nat Rev Dis Primers 2019 Aug 22;5(1):58. doi: 10.1038/s41572-019-0105-0. PMID: 31439850
European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; Clinical Practice Guideline Panel: Chair:; Panel members; EASL Governing Board representative:
J Hepatol 2019 Jun;70(6):1222-1261. Epub 2019 Mar 27 doi: 10.1016/j.jhep.2019.02.014. PMID: 30926241
Katarey D, Verma S
Clin Med (Lond) 2016 Dec;16(Suppl 6):s104-s109. doi: 10.7861/clinmedicine.16-6-s104. PMID: 27956449Free PMC Article

Therapy

Dauvilliers Y, Mignot E, Del Río Villegas R, Du Y, Hanson E, Inoue Y, Kadali H, Koundourakis E, Meyer S, Rogers R, Scammell TE, Sheikh SI, Swick T, Szakács Z, von Rosenstiel P, Wu J, Zeitz H, Murthy NV, Plazzi G, von Hehn C
N Engl J Med 2023 Jul 27;389(4):309-321. doi: 10.1056/NEJMoa2301940. PMID: 37494485
Day JW, Mendell JR, Mercuri E, Finkel RS, Strauss KA, Kleyn A, Tauscher-Wisniewski S, Tukov FF, Reyna SP, Chand DH
Drug Saf 2021 Oct;44(10):1109-1119. Epub 2021 Aug 12 doi: 10.1007/s40264-021-01107-6. PMID: 34383289Free PMC Article
Hassan A, Fontana RJ
Liver Int 2019 Jan;39(1):31-41. Epub 2018 Aug 19 doi: 10.1111/liv.13931. PMID: 30003672
Abenavoli L, Izzo AA, Milić N, Cicala C, Santini A, Capasso R
Phytother Res 2018 Nov;32(11):2202-2213. Epub 2018 Aug 6 doi: 10.1002/ptr.6171. PMID: 30080294
Floyd J, Mirza I, Sachs B, Perry MC
Semin Oncol 2006 Feb;33(1):50-67. doi: 10.1053/j.seminoncol.2005.11.002. PMID: 16473644

Prognosis

Li X, Tang J, Mao Y
Liver Int 2022 Aug;42(9):1999-2014. Epub 2022 Apr 2 doi: 10.1111/liv.15262. PMID: 35353431
Devarbhavi H, Aithal G, Treeprasertsuk S, Takikawa H, Mao Y, Shasthry SM, Hamid S, Tan SS, Philips CA, George J, Jafri W, Sarin SK; Asia Pacific Association of Study of Liver
Hepatol Int 2021 Apr;15(2):258-282. Epub 2021 Feb 27 doi: 10.1007/s12072-021-10144-3. PMID: 33641080
Shen T, Liu Y, Shang J, Xie Q, Li J, Yan M, Xu J, Niu J, Liu J, Watkins PB, Aithal GP, Andrade RJ, Dou X, Yao L, Lv F, Wang Q, Li Y, Zhou X, Zhang Y, Zong P, Wan B, Zou Z, Yang D, Nie Y, Li D, Wang Y, Han X, Zhuang H, Mao Y, Chen C
Gastroenterology 2019 Jun;156(8):2230-2241.e11. Epub 2019 Feb 8 doi: 10.1053/j.gastro.2019.02.002. PMID: 30742832
Asrani SK, Devarbhavi H, Eaton J, Kamath PS
J Hepatol 2019 Jan;70(1):151-171. Epub 2018 Sep 26 doi: 10.1016/j.jhep.2018.09.014. PMID: 30266282
Tostmann A, Boeree MJ, Aarnoutse RE, de Lange WC, van der Ven AJ, Dekhuijzen R
J Gastroenterol Hepatol 2008 Feb;23(2):192-202. Epub 2007 Nov 6 doi: 10.1111/j.1440-1746.2007.05207.x. PMID: 17995946

Clinical prediction guides

Zhang CJ, Meyer SR, O'Meara MJ, Huang S, Capeling MM, Ferrer-Torres D, Childs CJ, Spence JR, Fontana RJ, Sexton JZ
J Hepatol 2023 May;78(5):998-1006. Epub 2023 Feb 3 doi: 10.1016/j.jhep.2023.01.019. PMID: 36738840Free PMC Article
Hayashi PH, Lucena MI, Fontana RJ, Bjornsson ES, Aithal GP, Barnhart H, Gonzalez-Jimenez A, Yang Q, Gu J, Andrade RJ, Hoofnagle JH
Hepatology 2022 Jul;76(1):18-31. Epub 2022 Mar 22 doi: 10.1002/hep.32327. PMID: 35014066Free PMC Article
Chalasani NP, Maddur H, Russo MW, Wong RJ, Reddy KR; Practice Parameters Committee of the American College of Gastroenterology
Am J Gastroenterol 2021 May 1;116(5):878-898. doi: 10.14309/ajg.0000000000001259. PMID: 33929376
McGill MR, Jaeschke H
Adv Pharmacol 2019;85:221-239. Epub 2019 Mar 6 doi: 10.1016/bs.apha.2019.02.001. PMID: 31307588Free PMC Article
Danan G, Teschke R
Int J Mol Sci 2015 Dec 24;17(1) doi: 10.3390/ijms17010014. PMID: 26712744Free PMC Article

Recent systematic reviews

Xue H, Wei M, Ji L
Phytomedicine 2023 Sep;118:154961. Epub 2023 Jul 9 doi: 10.1016/j.phymed.2023.154961. PMID: 37453191
Takesue Y, Hanai Y, Oda K, Hamada Y, Ueda T, Mayumi T, Matsumoto K, Fujii S, Takahashi Y, Miyazaki Y, Kimura T; Japanese Antimicrobial Therapeutic Drug Monitoring Guideline Committee
Clin Ther 2022 Dec;44(12):1604-1623. Epub 2022 Nov 22 doi: 10.1016/j.clinthera.2022.10.005. PMID: 36424314
Piloiu C, Dumitrascu DL
Am J Ther 2021 Feb 3;28(3):e335-e340. doi: 10.1097/MJT.0000000000001341. PMID: 33590990
Alfaro-Lara R, Espinosa-Ortega HF, Arce-Salinas CA; PRECIS study group, all physicians belong to Division of Internal Medicine. Hospital Central Sur de Pemex
Reumatol Clin (Engl Ed) 2019 May-Jun;15(3):133-139. Epub 2017 Sep 1 doi: 10.1016/j.reuma.2017.07.020. PMID: 28867467
Buzzetti E, Parikh PM, Gerussi A, Tsochatzis E
Pharmacol Res 2017 Jun;120:97-108. Epub 2017 Mar 20 doi: 10.1016/j.phrs.2017.03.014. PMID: 28336373

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...