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Drug-induced disorder of liver

MedGen UID:
163652
•Concept ID:
C0860207
•
Disease or Syndrome
Synonyms: Disease, Drug-Induced Liver; Diseases, Drug-Induced Liver; Drug Induced Liver Disease; Drug Induced Liver Injury; Drug-Induced Liver Disease; Drug-Induced Liver Diseases; Drug-Induced Liver Injuries; Drug-Induced Liver Injury; Injuries, Drug-Induced Liver; Injury, Drug-Induced Liver; Liver Disease, Drug-Induced; Liver Diseases, Drug-Induced; Liver Injuries, Drug-Induced; Liver Injury, Drug Induced; Liver Injury, Drug-Induced
SNOMED CT: Drug-induced disorder of liver (427399008); Drug induced hepatotoxicity (427399008)

Definition

Damage to the liver tissue due to drug overdose. [from NCI]

Professional guidelines

PubMed

Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update.
Sarin SK, Choudhury A, Sharma MK, Maiwall R, Al Mahtab M, Rahman S, Saigal S, Saraf N, Soin AS, Devarbhavi H, Kim DJ, Dhiman RK, Duseja A, Taneja S, Eapen CE, Goel A, Ning Q, Chen T, Ma K, Duan Z, Yu C, Treeprasertsuk S, Hamid SS, Butt AS, Jafri W, Shukla A, Saraswat V, Tan SS, Sood A, Midha V, Goyal O, Ghazinyan H, Arora A, Hu J, Sahu M, Rao PN, Lee GH, Lim SG, Lesmana LA, Lesmana CR, Shah S, Prasad VGM, Payawal DA, Abbas Z, Dokmeci AK, Sollano JD, Carpio G, Shresta A, Lau GK, Fazal Karim M, Shiha G, Gani R, Kalista KF, Yuen MF, Alam S, Khanna R, Sood V, Lal BB, Pamecha V, Jindal A, Rajan V, Arora V, Yokosuka O, Niriella MA, Li H, Qi X, Tanaka A, Mochida S, Chaudhuri DR, Gane E, Win KM, Chen WT, Rela M, Kapoor D, Rastogi A, Kale P, Rastogi A, Sharma CB, Bajpai M, Singh V, Premkumar M, Maharashi S, Olithselvan A, Philips CA, Srivastava A, Yachha SK, Wani ZA, Thapa BR, Saraya A, Shalimar, Kumar A, Wadhawan M, Gupta S, Madan K, Sakhuja P, Vij V, Sharma BC, Garg H, Garg V, Kalal C, Anand L, Vyas T, Mathur RP, Kumar G, Jain P, Pasupuleti SSR, Chawla YK, Chowdhury A, Alam S, Song DS, Yang JM, Yoon EL; APASL ACLF Research Consortium (AARC) for APASL ACLF working Party.
Hepatol Int 2019 Jul;13(4):353-390. Epub 2019 Jun 6 doi: 10.1007/s12072-019-09946-3. PMID: 31172417Free PMC Article
EASL Clinical Practice Guidelines: Drug-induced liver injury.
European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; Clinical Practice Guideline Panel: Chair:; Panel members; EASL Governing Board representative:
J Hepatol 2019 Jun;70(6):1222-1261. Epub 2019 Mar 27 doi: 10.1016/j.jhep.2019.02.014. PMID: 30926241
Management of toxicities of immune checkpoint inhibitors.
Spain L, Diem S, Larkin J
Cancer Treat Rev 2016 Mar;44:51-60. Epub 2016 Feb 6 doi: 10.1016/j.ctrv.2016.02.001. PMID: 26874776

Recent clinical studies

Etiology

Drug induced liver injury: an update.
Garcia-Cortes M, Robles-Diaz M, Stephens C, Ortega-Alonso A, Lucena MI, Andrade RJ
Arch Toxicol 2020 Oct;94(10):3381-3407. Epub 2020 Aug 27 doi: 10.1007/s00204-020-02885-1. PMID: 32852569
Drug-induced liver injury.
Andrade RJ, Chalasani N, Björnsson ES, Suzuki A, Kullak-Ublick GA, Watkins PB, Devarbhavi H, Merz M, Lucena MI, Kaplowitz N, Aithal GP
Nat Rev Dis Primers 2019 Aug 22;5(1):58. doi: 10.1038/s41572-019-0105-0. PMID: 31439850
EASL Clinical Practice Guidelines: Drug-induced liver injury.
European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; Clinical Practice Guideline Panel: Chair:; Panel members; EASL Governing Board representative:
J Hepatol 2019 Jun;70(6):1222-1261. Epub 2019 Mar 27 doi: 10.1016/j.jhep.2019.02.014. PMID: 30926241
The diagnosis and management of idiosyncratic drug-induced liver injury.
Hassan A, Fontana RJ
Liver Int 2019 Jan;39(1):31-41. Epub 2018 Aug 19 doi: 10.1111/liv.13931. PMID: 30003672
Drug-induced liver injury.
Katarey D, Verma S
Clin Med (Lond) 2016 Dec;16(Suppl 6):s104-s109. doi: 10.7861/clinmedicine.16-6-s104. PMID: 27956449Free PMC Article

Diagnosis

ACG Clinical Guideline: Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury.
Chalasani NP, Maddur H, Russo MW, Wong RJ, Reddy KR; Practice Parameters Committee of the American College of Gastroenterology
Am J Gastroenterol 2021 May 1;116(5):878-898. doi: 10.14309/ajg.0000000000001259. PMID: 33929376
Drug induced liver injury: an update.
Garcia-Cortes M, Robles-Diaz M, Stephens C, Ortega-Alonso A, Lucena MI, Andrade RJ
Arch Toxicol 2020 Oct;94(10):3381-3407. Epub 2020 Aug 27 doi: 10.1007/s00204-020-02885-1. PMID: 32852569
Drug-induced liver injury.
Andrade RJ, Chalasani N, Björnsson ES, Suzuki A, Kullak-Ublick GA, Watkins PB, Devarbhavi H, Merz M, Lucena MI, Kaplowitz N, Aithal GP
Nat Rev Dis Primers 2019 Aug 22;5(1):58. doi: 10.1038/s41572-019-0105-0. PMID: 31439850
EASL Clinical Practice Guidelines: Drug-induced liver injury.
European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; Clinical Practice Guideline Panel: Chair:; Panel members; EASL Governing Board representative:
J Hepatol 2019 Jun;70(6):1222-1261. Epub 2019 Mar 27 doi: 10.1016/j.jhep.2019.02.014. PMID: 30926241
Drug-induced liver injury.
Katarey D, Verma S
Clin Med (Lond) 2016 Dec;16(Suppl 6):s104-s109. doi: 10.7861/clinmedicine.16-6-s104. PMID: 27956449Free PMC Article

Therapy

Acetaminophen Poisoning.
Chiew AL, Buckley NA
Crit Care Clin 2021 Jul;37(3):543-561. doi: 10.1016/j.ccc.2021.03.005. PMID: 34053705
Drug-induced liver injury.
Andrade RJ, Chalasani N, Björnsson ES, Suzuki A, Kullak-Ublick GA, Watkins PB, Devarbhavi H, Merz M, Lucena MI, Kaplowitz N, Aithal GP
Nat Rev Dis Primers 2019 Aug 22;5(1):58. doi: 10.1038/s41572-019-0105-0. PMID: 31439850
The diagnosis and management of idiosyncratic drug-induced liver injury.
Hassan A, Fontana RJ
Liver Int 2019 Jan;39(1):31-41. Epub 2018 Aug 19 doi: 10.1111/liv.13931. PMID: 30003672
Acute liver failure.
Bernal W, Auzinger G, Dhawan A, Wendon J
Lancet 2010 Jul 17;376(9736):190-201. doi: 10.1016/S0140-6736(10)60274-7. PMID: 20638564
Hepatotoxicity of chemotherapy.
Floyd J, Mirza I, Sachs B, Perry MC
Semin Oncol 2006 Feb;33(1):50-67. doi: 10.1053/j.seminoncol.2005.11.002. PMID: 16473644

Prognosis

Drug induced liver injury: an update.
Garcia-Cortes M, Robles-Diaz M, Stephens C, Ortega-Alonso A, Lucena MI, Andrade RJ
Arch Toxicol 2020 Oct;94(10):3381-3407. Epub 2020 Aug 27 doi: 10.1007/s00204-020-02885-1. PMID: 32852569
Drug-induced liver injury.
Andrade RJ, Chalasani N, Björnsson ES, Suzuki A, Kullak-Ublick GA, Watkins PB, Devarbhavi H, Merz M, Lucena MI, Kaplowitz N, Aithal GP
Nat Rev Dis Primers 2019 Aug 22;5(1):58. doi: 10.1038/s41572-019-0105-0. PMID: 31439850
Biomarkers of drug-induced liver injury.
McGill MR, Jaeschke H
Adv Pharmacol 2019;85:221-239. Epub 2019 Mar 6 doi: 10.1016/bs.apha.2019.02.001. PMID: 31307588Free PMC Article
Incidence and Etiology of Drug-Induced Liver Injury in Mainland China.
Shen T, Liu Y, Shang J, Xie Q, Li J, Yan M, Xu J, Niu J, Liu J, Watkins PB, Aithal GP, Andrade RJ, Dou X, Yao L, Lv F, Wang Q, Li Y, Zhou X, Zhang Y, Zong P, Wan B, Zou Z, Yang D, Nie Y, Li D, Wang Y, Han X, Zhuang H, Mao Y, Chen C
Gastroenterology 2019 Jun;156(8):2230-2241.e11. Epub 2019 Feb 8 doi: 10.1053/j.gastro.2019.02.002. PMID: 30742832
Acute liver failure.
Bernal W, Auzinger G, Dhawan A, Wendon J
Lancet 2010 Jul 17;376(9736):190-201. doi: 10.1016/S0140-6736(10)60274-7. PMID: 20638564

Clinical prediction guides

ACG Clinical Guideline: Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury.
Chalasani NP, Maddur H, Russo MW, Wong RJ, Reddy KR; Practice Parameters Committee of the American College of Gastroenterology
Am J Gastroenterol 2021 May 1;116(5):878-898. doi: 10.14309/ajg.0000000000001259. PMID: 33929376
Drug induced liver injury: an update.
Garcia-Cortes M, Robles-Diaz M, Stephens C, Ortega-Alonso A, Lucena MI, Andrade RJ
Arch Toxicol 2020 Oct;94(10):3381-3407. Epub 2020 Aug 27 doi: 10.1007/s00204-020-02885-1. PMID: 32852569
Drug-induced liver injury.
Andrade RJ, Chalasani N, Björnsson ES, Suzuki A, Kullak-Ublick GA, Watkins PB, Devarbhavi H, Merz M, Lucena MI, Kaplowitz N, Aithal GP
Nat Rev Dis Primers 2019 Aug 22;5(1):58. doi: 10.1038/s41572-019-0105-0. PMID: 31439850
Biomarkers of drug-induced liver injury.
McGill MR, Jaeschke H
Adv Pharmacol 2019;85:221-239. Epub 2019 Mar 6 doi: 10.1016/bs.apha.2019.02.001. PMID: 31307588Free PMC Article
Drug-Induced Liver Injury.
Fisher K, Vuppalanchi R, Saxena R
Arch Pathol Lab Med 2015 Jul;139(7):876-87. doi: 10.5858/arpa.2014-0214-RA. PMID: 26125428

Recent systematic reviews

Systematic review: ibuprofen-induced liver injury.
Zoubek ME, Lucena MI, Andrade RJ, Stephens C
Aliment Pharmacol Ther 2020 Mar;51(6):603-611. Epub 2020 Jan 27 doi: 10.1111/apt.15645. PMID: 31984540
Comparative effectiveness and safety of statins as a class and of specific statins for primary prevention of cardiovascular disease: A systematic review, meta-analysis, and network meta-analysis of randomized trials with 94,283 participants.
Yebyo HG, Aschmann HE, Kaufmann M, Puhan MA
Am Heart J 2019 Apr;210:18-28. Epub 2019 Jan 10 doi: 10.1016/j.ahj.2018.12.007. PMID: 30716508
Nimesulide-induced hepatotoxicity: A systematic review and meta-analysis.
Kwon J, Kim S, Yoo H, Lee E
PLoS One 2019;14(1):e0209264. Epub 2019 Jan 24 doi: 10.1371/journal.pone.0209264. PMID: 30677025Free PMC Article
Systematic review and meta-analysis of the efficacy and safety of leflunomide and methotrexate in the treatment of rheumatoid arthritis.
Alfaro-Lara R, Espinosa-Ortega HF, Arce-Salinas CA; PRECIS study group, all physicians belong to Division of Internal Medicine. Hospital Central Sur de Pemex
Reumatol Clin (Engl Ed) 2019 May-Jun;15(3):133-139. Epub 2017 Sep 1 doi: 10.1016/j.reuma.2017.07.020. PMID: 28867467
Current and future directions in the treatment and prevention of drug-induced liver injury: a systematic review.
Stine JG, Lewis JH
Expert Rev Gastroenterol Hepatol 2016;10(4):517-36. Epub 2015 Dec 25 doi: 10.1586/17474124.2016.1127756. PMID: 26633044Free PMC Article

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