Format

Send to

Choose Destination
J Hepatol. 2019 Jan;70(1):151-171. doi: 10.1016/j.jhep.2018.09.014. Epub 2018 Sep 26.

Burden of liver diseases in the world.

Author information

1
Baylor University Medical Center, Dallas, TX, USA.
2
St. John's Medical College Hospital, Bangalore, India.
3
Mayo Clinic College of Medicine, Rochester, MN, USA.
4
Mayo Clinic College of Medicine, Rochester, MN, USA. Electronic address: kamath.patrick@mayo.edu.

Abstract

Liver disease accounts for approximately 2 million deaths per year worldwide, 1 million due to complications of cirrhosis and 1million due to viral hepatitis and hepatocellular carcinoma. Cirrhosis is currently the 11th most common cause of death globally and liver cancer is the 16th leading cause of death; combined, they account for 3.5% of all deaths worldwide. Cirrhosis is within the top 20 causes of disability-adjusted life years and years of life lost, accounting for 1.6% and 2.1% of the worldwide burden. About 2 billion people consume alcohol worldwide and upwards of 75 million are diagnosed with alcohol-use disorders and are at risk of alcohol-associated liver disease. Approximately 2 billion adults are obese or overweight and over 400 million have diabetes; both of which are risk factors for non-alcoholic fatty liver disease and hepatocellular carcinoma. The global prevalence of viral hepatitis remains high, while drug-induced liver injury continues to increase as a major cause of acute hepatitis. Liver transplantation is the second most common solid organ transplantation, yet less than 10% of global transplantation needs are met at current rates. Though these numbers are sobering, they highlight an important opportunity to improve public health given that most causes of liver diseases are preventable.

KEYWORDS:

Burden; Chronic liver disease

PMID:
30266282
DOI:
10.1016/j.jhep.2018.09.014

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center