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Systolic hypertension

MedGen UID:
66361
•Concept ID:
C0221155
•
Disease or Syndrome
Synonyms: Hypertension, Systolic; Systolic Hypertension; Systolic Hypertensions
SNOMED CT: Systolic hypertension (56218007)

Definition

Abnormally high systolic blood pressure. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSystolic hypertension

Professional guidelines

PubMed

Nonpharmacological Management of Resistant Hypertension.
Sabbahi A, Severin R, Laddu D, Sharman JE, Arena R, Ozemek C
Curr Cardiol Rep 2021 Oct 1;23(11):166. doi: 10.1007/s11886-021-01601-4. PMID: 34599399Free PMC Article
Treatment strategies for isolated systolic hypertension in elderly patients.
Angeli F, Verdecchia P, Masnaghetti S, Vaudo G, Reboldi G
Expert Opin Pharmacother 2020 Oct;21(14):1713-1723. Epub 2020 Jun 25 doi: 10.1080/14656566.2020.1781092. PMID: 32584617
Hypertension Management in Older and Frail Older Patients.
Benetos A, Petrovic M, Strandberg T
Circ Res 2019 Mar 29;124(7):1045-1060. doi: 10.1161/CIRCRESAHA.118.313236. PMID: 30920928

Recent clinical studies

Etiology

Isolated systolic hypertension in Asia.
Tsai TY, Cheng HM, Chuang SY, Chia YC, Soenarta AA, Minh HV, Siddique S, Turana Y, Tay JC, Kario K, Chen CH
J Clin Hypertens (Greenwich) 2021 Mar;23(3):467-474. Epub 2020 Nov 29 doi: 10.1111/jch.14111. PMID: 33249701Free PMC Article
Treatment strategies for isolated systolic hypertension in elderly patients.
Angeli F, Verdecchia P, Masnaghetti S, Vaudo G, Reboldi G
Expert Opin Pharmacother 2020 Oct;21(14):1713-1723. Epub 2020 Jun 25 doi: 10.1080/14656566.2020.1781092. PMID: 32584617
Large-Artery Stiffness in Health and Disease: JACC State-of-the-Art Review.
Chirinos JA, Segers P, Hughes T, Townsend R
J Am Coll Cardiol 2019 Sep 3;74(9):1237-1263. doi: 10.1016/j.jacc.2019.07.012. PMID: 31466622Free PMC Article
ACOG Committee Opinion No. 767: Emergent Therapy for Acute-Onset, Severe Hypertension During Pregnancy and the Postpartum Period.
Obstet Gynecol 2019 Feb;133(2):e174-e180. doi: 10.1097/AOG.0000000000003075. PMID: 30575639
Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group.
JAMA 1991 Jun 26;265(24):3255-64. PMID: 2046107

Diagnosis

Isolated systolic hypertension of the young and sodium intake.
D'Elia L, Strazzullo P
Minerva Med 2022 Oct;113(5):788-797. Epub 2021 Sep 29 doi: 10.23736/S0026-4806.21.07740-5. PMID: 34586768
Isolated systolic hypertension in Asia.
Tsai TY, Cheng HM, Chuang SY, Chia YC, Soenarta AA, Minh HV, Siddique S, Turana Y, Tay JC, Kario K, Chen CH
J Clin Hypertens (Greenwich) 2021 Mar;23(3):467-474. Epub 2020 Nov 29 doi: 10.1111/jch.14111. PMID: 33249701Free PMC Article
Excess Body Weight, Insulin Resistance and Isolated Systolic Hypertension: Potential Pathophysiological Links.
D'Elia L, Strazzullo P
High Blood Press Cardiovasc Prev 2018 Mar;25(1):17-23. Epub 2017 Nov 2 doi: 10.1007/s40292-017-0240-1. PMID: 29098651
Mild cognitive impairment.
Gauthier S, Reisberg B, Zaudig M, Petersen RC, Ritchie K, Broich K, Belleville S, Brodaty H, Bennett D, Chertkow H, Cummings JL, de Leon M, Feldman H, Ganguli M, Hampel H, Scheltens P, Tierney MC, Whitehouse P, Winblad B; International Psychogeriatric Association Expert Conference on mild cognitive impairment
Lancet 2006 Apr 15;367(9518):1262-70. doi: 10.1016/S0140-6736(06)68542-5. PMID: 16631882
Hypertension in women.
Rosenthal T, Oparil S
J Hum Hypertens 2000 Oct-Nov;14(10-11):691-704. doi: 10.1038/sj.jhh.1001095. PMID: 11095160

Therapy

Treatment strategies for isolated systolic hypertension in elderly patients.
Angeli F, Verdecchia P, Masnaghetti S, Vaudo G, Reboldi G
Expert Opin Pharmacother 2020 Oct;21(14):1713-1723. Epub 2020 Jun 25 doi: 10.1080/14656566.2020.1781092. PMID: 32584617
Effect of Antihypertensive Medication Reduction vs Usual Care on Short-term Blood Pressure Control in Patients With Hypertension Aged 80 Years and Older: The OPTIMISE Randomized Clinical Trial.
Sheppard JP, Burt J, Lown M, Temple E, Lowe R, Fraser R, Allen J, Ford GA, Heneghan C, Hobbs FDR, Jowett S, Kodabuckus S, Little P, Mant J, Mollison J, Payne RA, Williams M, Yu LM, McManus RJ; OPTIMISE Investigators
JAMA 2020 May 26;323(20):2039-2051. doi: 10.1001/jama.2020.4871. PMID: 32453368Free PMC Article
Effects of Sacubitril/Valsartan Versus Olmesartan on Central Hemodynamics in the Elderly With Systolic Hypertension: The PARAMETER Study.
Williams B, Cockcroft JR, Kario K, Zappe DH, Brunel PC, Wang Q, Guo W
Hypertension 2017 Mar;69(3):411-420. Epub 2017 Jan 16 doi: 10.1161/HYPERTENSIONAHA.116.08556. PMID: 28093466
Mild cognitive impairment.
Gauthier S, Reisberg B, Zaudig M, Petersen RC, Ritchie K, Broich K, Belleville S, Brodaty H, Bennett D, Chertkow H, Cummings JL, de Leon M, Feldman H, Ganguli M, Hampel H, Scheltens P, Tierney MC, Whitehouse P, Winblad B; International Psychogeriatric Association Expert Conference on mild cognitive impairment
Lancet 2006 Apr 15;367(9518):1262-70. doi: 10.1016/S0140-6736(06)68542-5. PMID: 16631882
Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group.
JAMA 1991 Jun 26;265(24):3255-64. PMID: 2046107

Prognosis

Large-Artery Stiffness in Health and Disease: JACC State-of-the-Art Review.
Chirinos JA, Segers P, Hughes T, Townsend R
J Am Coll Cardiol 2019 Sep 3;74(9):1237-1263. doi: 10.1016/j.jacc.2019.07.012. PMID: 31466622Free PMC Article
Stenting and medical therapy for atherosclerotic renal-artery stenosis.
Cooper CJ, Murphy TP, Cutlip DE, Jamerson K, Henrich W, Reid DM, Cohen DJ, Matsumoto AH, Steffes M, Jaff MR, Prince MR, Lewis EF, Tuttle KR, Shapiro JI, Rundback JH, Massaro JM, D'Agostino RB Sr, Dworkin LD; CORAL Investigators
N Engl J Med 2014 Jan 2;370(1):13-22. Epub 2013 Nov 18 doi: 10.1056/NEJMoa1310753. PMID: 24245566Free PMC Article
What is the most important component of blood pressure: systolic, diastolic or pulse pressure?
Strandberg TE, Pitkala K
Curr Opin Nephrol Hypertens 2003 May;12(3):293-7. doi: 10.1097/00041552-200305000-00011. PMID: 12698068
Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group.
JAMA 1991 Jun 26;265(24):3255-64. PMID: 2046107
Geriatric hypertension.
Franklin SS
Med Clin North Am 1983 Mar;67(2):395-417. doi: 10.1016/s0025-7125(16)31211-1. PMID: 6338322

Clinical prediction guides

Efficacy of sacubitril/valsartan versus olmesartan in Japanese patients with essential hypertension: a randomized, double-blind, multicenter study.
Rakugi H, Kario K, Yamaguchi M, Sasajima T, Gotou H, Zhang J
Hypertens Res 2022 May;45(5):824-833. Epub 2022 Jan 21 doi: 10.1038/s41440-021-00819-7. PMID: 35058583Free PMC Article
Large-Artery Stiffness in Health and Disease: JACC State-of-the-Art Review.
Chirinos JA, Segers P, Hughes T, Townsend R
J Am Coll Cardiol 2019 Sep 3;74(9):1237-1263. doi: 10.1016/j.jacc.2019.07.012. PMID: 31466622Free PMC Article
Effect of Systolic and Diastolic Blood Pressure on Cardiovascular Outcomes.
Flint AC, Conell C, Ren X, Banki NM, Chan SL, Rao VA, Melles RB, Bhatt DL
N Engl J Med 2019 Jul 18;381(3):243-251. doi: 10.1056/NEJMoa1803180. PMID: 31314968
MIND diet slows cognitive decline with aging.
Morris MC, Tangney CC, Wang Y, Sacks FM, Barnes LL, Bennett DA, Aggarwal NT
Alzheimers Dement 2015 Sep;11(9):1015-22. Epub 2015 Jun 15 doi: 10.1016/j.jalz.2015.04.011. PMID: 26086182Free PMC Article
What is the most important component of blood pressure: systolic, diastolic or pulse pressure?
Strandberg TE, Pitkala K
Curr Opin Nephrol Hypertens 2003 May;12(3):293-7. doi: 10.1097/00041552-200305000-00011. PMID: 12698068

Recent systematic reviews

Effect of antihypertensive treatment in isolated systolic hypertension (ISH) - systematic review and meta-analysis of randomised controlled trials.
Brunström M, Carlberg B, Kjeldsen SE
Blood Press 2023 Dec;32(1):2226757. doi: 10.1080/08037051.2023.2226757. PMID: 37395100
Treatment strategies for isolated systolic hypertension in elderly patients.
Angeli F, Verdecchia P, Masnaghetti S, Vaudo G, Reboldi G
Expert Opin Pharmacother 2020 Oct;21(14):1713-1723. Epub 2020 Jun 25 doi: 10.1080/14656566.2020.1781092. PMID: 32584617
Midlife Hypertension and Alzheimer's Disease: A Systematic Review and Meta-Analysis.
Lennon MJ, Makkar SR, Crawford JD, Sachdev PS
J Alzheimers Dis 2019;71(1):307-316. doi: 10.3233/JAD-190474. PMID: 31381518
Is Chinese herbal medicine effective for elderly isolated systolic hypertension? A systematic review and meta-analysis.
Cao Y, Liu LT, Wu M
Chin J Integr Med 2017 Apr;23(4):298-305. Epub 2016 May 25 doi: 10.1007/s11655-016-2257-z. PMID: 27225294
Severe systolic hypertension and the search for safer motherhood.
Martin JN Jr
Semin Perinatol 2016 Mar;40(2):119-23. Epub 2015 Dec 23 doi: 10.1053/j.semperi.2015.11.018. PMID: 26723235

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