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Alzheimers Dement. 2015 Sep;11(9):1015-22. doi: 10.1016/j.jalz.2015.04.011. Epub 2015 Jun 15.

MIND diet slows cognitive decline with aging.

Author information

1
Department of Internal Medicine at Rush University Medical Center, Chicago, IL, USA. Electronic address: martha_c_morris@rush.edu.
2
Department of Clinical Nutrition at Rush University Medical Center, Chicago, IL, USA.
3
Department of Internal Medicine at Rush University Medical Center, Chicago, IL, USA.
4
Department of Nutrition, Harvard School of Public Health, Harvard University, Boston, MA, USA.
5
Department of Behavioral Sciences at Rush University Medical Center, Chicago, IL, USA; Department of Neurological Sciences at Rush University Medical Center, Chicago, IL, USA; Rush Alzheimer's Disease Center at Rush University Medical Center, Chicago, IL, USA.
6
Department of Neurological Sciences at Rush University Medical Center, Chicago, IL, USA; Rush Alzheimer's Disease Center at Rush University Medical Center, Chicago, IL, USA.

Abstract

INTRODUCTION:

The Mediterranean and dash diets have been shown to slow cognitive decline; however, neither diet is specific to the nutrition literature on dementia prevention.

METHODS:

We devised the Mediterranean-Dietary Approach to Systolic Hypertension (DASH) diet intervention for neurodegenerative delay (MIND) diet score that specifically captures dietary components shown to be neuroprotective and related it to change in cognition over an average 4.7 years among 960 participants of the Memory and Aging Project.

RESULTS:

In adjusted mixed models, the MIND score was positively associated with slower decline in global cognitive score (β = 0.0092; P < .0001) and with each of five cognitive domains. The difference in decline rates for being in the top tertile of MIND diet scores versus the lowest was equivalent to being 7.5 years younger in age.

DISCUSSION:

The study findings suggest that the MIND diet substantially slows cognitive decline with age. Replication of these findings in a dietary intervention trial would be required to verify its relevance to brain health.

KEYWORDS:

Aging; Cognition; Cognitive decline; Diet; Epidemiologic study; Nutrition

PMID:
26086182
PMCID:
PMC4581900
DOI:
10.1016/j.jalz.2015.04.011
[Indexed for MEDLINE]
Free PMC Article

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