Nephrotic Syndrome and Focal Segmental Glomerulosclerosis panel
GTR Test Accession: Help GTR000522221.5
Last updated in GTR: 2022-04-08
Last annual review date for the lab: 2022-04-08 Past due LinkOut
At a Glance
Diagnosis; Monitoring; Predictive
Focal segmental glomerulosclerosis; Alport syndrome; Autosomal dominant Alport syndrome; ...
ACE (17q23.3), ACTN4 (19q13.2), ANLN (7p14.2), APOL1 (22q12.3), ARHGAP24 (4q21.23-21.3), ...
Molecular Genetics - Sequence analysis of the entire coding region: Next-Generation (NGS)/Massively parallel sequencing (MPS)
Not provided
Not provided
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Ordering Information
Offered by: Help
Clinical Genomics Laboratory
View lab's website
View lab's test page
Specimen Source: Help
Who can order: Help
  • Licensed Physician
  • Nurse Practitioner
Lab contact: Help
Meagan Corliss, Genetic Counselor
Contact Policy: Help
Laboratory can only accept contact from health care providers. Patients/families are encouraged to discuss genetic testing options with their health care provider.
How to Order: Help
To order a test, complete and submit a requisition form that can be found on our website (
Order URL
Test service: Help
Clinical Testing/Confirmation of Mutations Identified Previously
Informed consent required: Help
Decline to answer
Test strategy: Help
aCGH testing for NPHS1, NPHS2, COL4A5, CLCN5 is performed at an outside CAP/CLIA laboratory when sequencing does not identify any disease causing alterations.
Pre-test genetic counseling required: Help
Decline to answer
Post-test genetic counseling required: Help
Decline to answer
Recommended fields not provided:
Conditions Help
Total conditions: 10
Condition/Phenotype Identifier
Test Targets
Genes Help
Total genes: 52
Gene Associated Condition Germline or Somatic Allele (Lab-provided) Variant in NCBI
Total methods: 1
Method Category Help
Test method Help
Instrument *
Sequence analysis of the entire coding region
Next-Generation (NGS)/Massively parallel sequencing (MPS)
* Instrument: Not provided
Clinical Information
Test purpose: Help
Diagnosis; Monitoring; Predictive
Recommended fields not provided:
Technical Information
Availability: Help
Tests performed
Interpretation performed in-house
Report generated in-house
Specimen preparation performed in-house
Wet lab work performed both in-house and at an outside lab

Test performance comments
aCGH testing for the NPHS1, NPHS2, COL4A5, CLCN5 genes is performed at an outside CAP/CLIA lab when sequencing does not identify any disease causing alterations.
Analytical Validity: Help
sensitivity of 96.6-98.9% and a specificity of 100.0%
Proficiency testing (PT):
Is proficiency testing performed for this test? Help

Method used for proficiency testing: Help
Formal PT program

PT Provider: Help
American College of Medical Genetics / College of American Pathologists, ACMG/CAP
Recommended fields not provided:
Regulatory Approval
FDA Review: Help
Not provided
Additional Information

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