GEO DataSets

(Submitter supplied) GSE2240 contains two different experimental subsets: 1) Comparison of atrial and ventricular gene expression (atrial tissue of patients with sinus rhythm vs. human left ventricular non-failing myocardium) The purpose of our investigation was to identify the transcriptional basis for ultrastructural and functional specialization of human atria and ventricles. Using exploratory microarray analysis (Affymetrix U133A+B), we detected 11,740 transcripts expressed in human heart, representing the most comprehensive report of the human myocardial transcriptome to date. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS1557 GDS1559

Platforms:

GPL97 GPL96

70 Samples

Download data: CEL

Analysis of atrium from patients with permanent atrial fibrillation (AF). AF is associated with extensive structural, contractile, and electrophysiological remodeling. Results identify adoption of a ventricular-like genomic signature as a general feature of the fibrillating atrium.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state, 2 tissue sets

Platform:

GPL97

Series:

GSE2240

35 Samples

Download data: CEL

Analysis of right atria and left ventricles of hearts. While both the ventricle and atrium contract, the atrium is also a source and target for neurohumoral signals. Results provide insight into the molecular basis for the ultrastructural and functional differences between the atrium and ventricle.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 tissue sets

Platform:

GPL97

Series:

GSE2240

25 Samples

Download data: CEL

(Submitter supplied) Spotted mouse cDNA array containing 13872 spots. Clones originate from a combination of in house and commercial (IMAGE) mouse EST libraries. Details of library construction and all target clones can be found at http://pga.swmed.edu.

Organism:

Mus musculus

1 DataSet

1 Series

6 Samples

Download data

(Submitter supplied) Atrial fibrillation (AF) is the most common sustained arrhythmia with increased risk of stroke and congestive heart failure. AF is a highly genetic heterogeneous disease, but a large proportion of AF cannot be explained by genetic variants only. Some risk factors of AF, tendentious heritable phenomenon, potentially reversible conditions and some subtypes without DNA sequence variation all indicate the participation of DNA methylation in the pathogenesis of AF.

Organism:

Homo sapiens

Type:

Methylation profiling by array

Platform:

GPL13534

11 Samples

Download data: IDAT

(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3643

Platform:

GPL1355

24 Samples

Download data: CEL

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 6 dose sets

Platform:

GPL1355

Series:

GSE10748

24 Samples

Download data: CEL

(Submitter supplied) computational analysis of transcriptomic information during erythroid development Keywords: erythroid differentiation

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2431

Platform:

GPL570

18 Samples

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Analysis of adult differentiating CD34+ hematopoietic progenitor cells at various time points up to 11 days of growth in serum-free medium containing erythropoietin, interleukin-3 and stem cell factor. Results provide insight into the molecular basis of erythropoiesis.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 6 time sets

Platform:

GPL570

Series:

GSE4655

18 Samples

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(Submitter supplied) Time and dose related expression profiles of rat right heart tissue in microsphere bead model for Pulmonary embolism Keywords: Time course and dose response in experimental PE

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3414

Platform:

GPL1355

45 Samples

Download data: CEL

Analysis of right ventricles (RV) of animals for up to 18 hours after injection with polystyrene microsphere beads to induce pulmonary embolism (PE). Animals injected with 1.3 or 2.0 million microspheres/100g body weight. Results provide insight into the mechanisms leading to RV failure after PE.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 3 dose, 3 time sets

Platform:

GPL1355

Series:

GSE6104

45 Samples

Download data: CEL

(Submitter supplied) Time course of Arabidopsis seedlings treated with 6-Benzyl adenine dissolved in diluted KOH for 15 min or 2 hours Keywords: other

Organism:

Arabidopsis thaliana

Type:

Expression profiling by array

Platform:

GPL198

13 Samples

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(Submitter supplied) Pharmacological and gene ablation studies have demonstrated a crucial role of the cardiac natriuretic peptides (NP) hormones ANF and BNP in the maintenance of cardiovascular homeostasis. In addition, hypertension and chronic congestive heart failure are clinical entities that may be regarded as states of relative NP deficiency. Hence the study of the function of the endocrine heart is highly relevant. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3625

Platform:

GPL1355

8 Samples

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Comparison of heart atrial appendages and ventricular free walls. Unlike ventricular muscle cells, atrial muscle cells produce the hormones atrial natriuretic factor and brain natriuretic peptide. Results provide insight into the molecular basis of this phenotypic difference.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 2 tissue sets

Platform:

GPL1355

Series:

GSE5266

8 Samples

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(Submitter supplied) Analysis of the expression profile of adult mice heterozygous for Pitx2 isoform C.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6887

20 Samples

Download data: TXT

(Submitter supplied) Purpose: Common genetic variation at chromosome 4q25 lead to the strongest locus associated with atrial fibrillation (AF), the most frequent arrhythmia. The mechanism of association is currently unknown. We recently have identified a novel noncoding RNA expressed in the left atria. To determine the potential functional roles of the LNCRNA adjacent to PITX2 (PANCR) via knockdown in cardiomyocytes Methods and Results: H9 differentiated cardiomyocytes were treated with siRNA targeting PANCR and PITX2c and a scrambled control in triplicate. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platforms:

GPL11154 GPL15520

18 Samples

Download data: TXT

(Submitter supplied) Background: Although chamber specialization is critical for proper cardiac function, a comprehensive, genome-wide analysis of the cardiac transcriptome, including identification of regional differences in mRNA and lncRNA expression patterns for the four chambers and interventricular septum of the non-failing human heart, has not been performed. Methods and Results: mRNA and long noncoding RNA (lncRNA) transcriptional profiling of the left (LA) and right (RA) atria, left (LV) and right (RV) ventricles, and the interventricular septum (IVS) of non-failing human hearts (N=8) was performed by deep sequencing. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

40 Samples

Download data: TXT

(Submitter supplied) In this study, we have identified MEF2A-sensitive genes in atrial and ventricular chambers of the adult heart. MEF2A is a member of the myocyte enhancer factor 2 (MEF2) family of transcription factors. MEF2 proteins are expressed in skeletal and cardiac muscle tissues and are conserved across many mammalian species, but the gene programs regulated by MEF2A in adult cardiac chambers are largely unknown. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL11078

4 Samples

Download data: CEL

(Submitter supplied) Endocardial (EE) and Aortic (AE) endothelial cells were isolated from the same two rats, pooled (EE and AE kept separately) and cultured for 2 passages. Culture conditions and confluence of EE and AE cell cultures were kept as identical as possible. RNA was isolated and the expression profile of both endothelial cell types was compared using the Affymetrix rat genome U34A array. Keywords: parallel sample

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS695

Platform:

GPL85

2 Samples

Download data: CEL, EXP, RPT

Gene expression profiles of endocardial (EE) and aortic (AE) endothelial cells. EE and AE genetic diversity in culture reflects in vivo physiological diversity.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 cell type sets

Platform:

GPL85

Series:

GSE1478

2 Samples

Download data: CEL, EXP, RPT