GSM2695342[Accession] - GEO DataSets

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Items: 4

Select item 2001008641.

SETDB1 prevents TET2-dependent activation of IAP retroelements in naïve embryonic stem cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
24 Samples

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Accession:: GSE100864

ID:: 200100864

PubMed Full text in PMC Similar studies

Select item 2001008632.

Rescue of Tet2 KO ES cells in primed or naïve state

(Submitter supplied) Endogenous retroviruses (ERVs), which are responsible for 10% of spontaneous mouse mutations, are kept under control via several epigenetic mechanisms. The H3K9 histone methyltransferase SETDB1 is essential for ERV repression in embryonic stem cells (ESCs), with DNA methylation also playing an important role. It has been suggested that SETDB1 protects ERVs from TET-dependent DNA demethylation, but the relevance of this mechanism for ERV expression remains unclear. more...