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Lam C, Tan W, Leighton M, et al. Efficacy and mode of action of mesalazine in the treatment of diarrhoea-predominant irritable bowel syndrome (IBS-D): a multicentre, parallel-group, randomised placebo-controlled trial. Southampton (UK): NIHR Journals Library; 2015 Mar. (Efficacy and Mechanism Evaluation, No. 2.2.)
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Efficacy and mode of action of mesalazine in the treatment of diarrhoea-predominant irritable bowel syndrome (IBS-D): a multicentre, parallel-group, randomised placebo-controlled trial.
Show details- 5-ASA
5-aminosalicylic acid
- 5-HT
serotonin
- AE
adverse event
- BSFS
Bristol Stool Form Scale
- CACE
Complier Average Causal Effect
- CD3
CD3+ T lymphocytes
- CI
confidence interval
- CONSORT
Consolidated Standards of Reporting Trials
- CPA3
carboxypeptidase A3
- CTU
Clinical Trials Unit
- ELISA
enzyme-linked immunosorbent assay
- EOT
end of trial
- EQ-5D
European Quality of Life-5 Dimensions
- HADS
Hospital Anxiety and Depression Scale
- HV
healthy volunteer
- IBS
irritable bowel syndrome
- IBS-D
diarrhoea-predominant irritable bowel syndrome
- IL-1β
interleukin-1 beta
- IMP
investigational medicinal product
- IQR
interquartile range
- ITT
intention to treat
- MRI
magnetic resonance imaging
- PCRN
Primary Care Research Network
- PHQ-15
Patient Health Questionnaire 15
- PI-IBS
postinfective irritable bowel syndrome
- SD
standard deviation
- SSRI
selective serotonin reuptake inhibitor
- TCA
tricyclic antidepressant
- TNF
tumour necrosis factor
- TNF-α
tumour necrosis factor alpha
- List of abbreviations - Efficacy and mode of action of mesalazine in the treatme...List of abbreviations - Efficacy and mode of action of mesalazine in the treatment of diarrhoea-predominant irritable bowel syndrome (IBS-D): a multicentre, parallel-group, randomised placebo-controlled trial
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