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Lam C, Tan W, Leighton M, et al. Efficacy and mode of action of mesalazine in the treatment of diarrhoea-predominant irritable bowel syndrome (IBS-D): a multicentre, parallel-group, randomised placebo-controlled trial. Southampton (UK): NIHR Journals Library; 2015 Mar. (Efficacy and Mechanism Evaluation, No. 2.2.)

Cover of Efficacy and mode of action of mesalazine in the treatment of diarrhoea-predominant irritable bowel syndrome (IBS-D): a multicentre, parallel-group, randomised placebo-controlled trial

Efficacy and mode of action of mesalazine in the treatment of diarrhoea-predominant irritable bowel syndrome (IBS-D): a multicentre, parallel-group, randomised placebo-controlled trial.

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List of abbreviations

5-ASA

5-aminosalicylic acid

5-HT

serotonin

AE

adverse event

BSFS

Bristol Stool Form Scale

CACE

Complier Average Causal Effect

CD3

CD3+ T lymphocytes

CI

confidence interval

CONSORT

Consolidated Standards of Reporting Trials

CPA3

carboxypeptidase A3

CTU

Clinical Trials Unit

ELISA

enzyme-linked immunosorbent assay

EOT

end of trial

EQ-5D

European Quality of Life-5 Dimensions

HADS

Hospital Anxiety and Depression Scale

HV

healthy volunteer

IBS

irritable bowel syndrome

IBS-D

diarrhoea-predominant irritable bowel syndrome

IL-1β

interleukin-1 beta

IMP

investigational medicinal product

IQR

interquartile range

ITT

intention to treat

MRI

magnetic resonance imaging

PCRN

Primary Care Research Network

PHQ-15

Patient Health Questionnaire 15

PI-IBS

postinfective irritable bowel syndrome

SD

standard deviation

SSRI

selective serotonin reuptake inhibitor

TCA

tricyclic antidepressant

TNF

tumour necrosis factor

TNF-α

tumour necrosis factor alpha

Copyright © Queen’s Printer and Controller of HMSO 2015. This work was produced by Lam et al. under the terms of a commissioning contract issued by the Secretary of State for Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should be addressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK.

Included under terms of UK Non-commercial Government License.

Bookshelf ID: NBK280106

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