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Hempel S, Newberry S, Ruelaz A, et al. Safety of Probiotics to Reduce Risk and Prevent or Treat Disease. Rockville (MD): Agency for Healthcare Research and Quality (US); 2011 Apr. (Evidence Reports/Technology Assessments, No. 200.)

  • This publication is provided for historical reference only and the information may be out of date.

This publication is provided for historical reference only and the information may be out of date.

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Safety of Probiotics to Reduce Risk and Prevent or Treat Disease.

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Included Studies That Addressed Specific Adverse Events

  • Abrahamsson TR, Jakobsson T, et al. Probiotics in prevention of IgE-associated eczema: a double-blind, randomized, placebo-controlled trial. J Allergy Clin Immunol. 2007;119(5):1174–1180. PubMed. [PubMed: 17349686]
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  • Anukam K, Osazuwa E, et al. Augmentation of antimicrobial metronidazole therapy of bacterial vaginosis with oral probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14: randomized, double-blind, placebo controlled trial. Microbes Infect. 2006;8(6):1450–1454. PubMed. [PubMed: 16697231]
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  • Brophy S, Burrows CL, et al. Internet-based randomised controlled trials for the evaluation of complementary and alternative medicines: probiotics in spondyloarthropathy. BMC Musculoskelet Disord. 2008;9:4. PubMed. [PMC free article: PMC2241591] [PubMed: 18190710]
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  • Bu LN, Chang MH, et al. Lactobacillus casei rhamnosus Lcr35 in children with chronic constipation. Pediatr Int. 2007;49(4):485–490. PubMed. [PubMed: 17587273]
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  • Chou IC, Kuo HT, et al. Lack of effects of oral probiotics on growth and neurodevelopmental outcomes in preterm very low birth weight infants. J Pediatr. 2010;156(3):393–396. PubMed. 2010 update. [PubMed: 19914635]
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