Table 2, pKa's and relative activation of several leaving groups relevant to the reactions of transmitting genetic information - Madame Curie Bioscience Database

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Conjugate Acid of Leaving Group	pKa	Activation
RNH₂	≈35	no
ROH	15-20	weak
H-OH	15.7	weak
ribose hydroxyls	12.35	moderate
HP₂O₇ ^-2	12.32	moderate
HOCH₂CN	11.0	good
RSH	10.6	good
RNH₃ ⁺	≈10	good
H₂P₂O₇ ^-1	7.09	very good
H-AMP	6.2	very good
H₃P₂O₇	2.15	very good

Madame Curie Bioscience Database [Internet].

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