| Carcinogen | Inhibitor/Treatment | Species | Tissue | Tumor | Incidence | Refs. |
|---|---|---|---|---|---|---|
| Streptozotocin | Nicotinamide | Rat*1 | Kidney | Renal cell tumor | ↓*5 | Rakieten, 197130 |
| Nicotinamide | Rat*1 | Pancreas | Insulinoma | ↑*6 | Rakieten, 197130 | |
| 3-Aminobenzamide | Rat*2 | Pancreas | Insulinoma | ↑ | Yamagami, 198525 | |
| Benzamide | Rat*2 | Pancreas | Insulinoma | ↑ | Yamagami, 198525 | |
| Alloxan | 3-Aminobenzamide | Rat*2 | Pancreas | Insulinoma | ↑ | Yamagami, 198525 |
| Benzamide | Rat*2 | Pancreas | Insulinoma | ↑ | Yamagami, 198525 | |
| Diethylnitrosamine | 3-Aminobenzamide | Rat*2 | Liver | γ-GTP positive foci*7 | ↑ | Takahashi 198226 |
| Nicotinamide | Rat*3 | Kidney | Renal tubular cell tumor | ↑ | Rosenberg 198527 | |
| Ethylnitrosourea | Supplimentation with niacin or nicotinamide | Rat*4 | Liver | HCC | ↓ | Boyonoski 200235 |
| 7β,8α-Dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzopyrene | 3-Aminobenzamide | Rat*8 | Liver | γ-GTP positive foci | ↑ | Denda 198833 |
| Methylnitrosourea | 3-Aminobenzamide | Rat*1 | Liver | γ-GTP positive foci | →*9 | Denda 198833 |
| 1,2-Dimethylhydrazine | 3-Aminobenzamide | Rat*2 | Liver | γ-GTP positive foci | ↑ | Denda 198833 |
| 3-Aminobenzamide | Rat*3 | Liver | γ-GTP positive foci | → | Denda 198833 | |
| N-Nitrosobis(2-hydroxypropyl) amine | 3-Aminobenzamide | Rat*2 | Liver | γ-GTP positive foci | → | Denda 198833 |
| Ethylnitrosourea | Niacin deficiency | Rat*4 | Liver | GST-P positive foci*10 | ↑ | Boyonoski 200234 |
| Diethylnitrosamine + phenobarbital | 3-Aminobenzamide | Rat*3 | Liver | GST-P positive foci | ↓ | Tsujiuchi 199031 |
| Luminol | Rat*3 | Liver | GST-P positive foci | ↓ | Tsujiuchi 199031 | |
| Methylazoxymethanol | 3-Aminobenzamide | Rat*3 | Colon | Adenocarcinoma | ↓ | Nakagawa 198832 |
| 3-Aminobenzamide | Medaka (Oryzias latipes) | Liver | Hepatoma | ↑ | Miwa 198528 | |
| Dimethylbenza[a]anthracene | 3-Methoxybenzamide | Hamster | Cheek pouch | Oral squamous cell carcinoma | ↑ | Miller 198929 |
*1 Holtzman rat.
*2 Wistar rat.
*3 Fischer rat.
*4 Long-Evans rat.
*5 Suppression rat.
*6 Elevation rat.
*7 γ-Glutamyl transpeptidase.
*8 Wistar & Fischer rat.
*9 No change.
*10 Glutathione S-transferase placental form.
From: Role of Poly-ADP-Ribosylation in Cancer Development
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