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LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-.
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LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet].
Show detailsOVERVIEW
Introduction
Dimenhydrinate is a first generation antihistamine that is used for treatment or prevention of motion sickness or symptoms of nausea and dizziness. Dimenhydrinate has not been linked to instances of clinically apparent acute liver injury.
Background
Dimenhydrinate (dye" men hye' dri nate) is the 8-chlorotheophylline salt of diphenhydramine and, thus, combines a first generation antihistamine with a xanthine that is added to counteract the drowsiness caused by diphenhydramine. This combination was approved as an over-the-counter agent in 2004 and is used largely for prevention of motion sickness and nausea. Dimenhydrinate is available in multiple generic forms as tablets 25 or 50 mg or oral solutions, most of which are available without prescription, a common brand name being Dramamine. A liquid formulation for intramuscular use is also available. The typical adult oral dose is 50 mg taken an hour before expected travel and up to three or four times daily. Common side effects include sedation, impairment of motor function, confusion, dizziness, blurred vision, dry mouth and throat, palpitations, tachycardia, abdominal distress, constipation and headache. Antihistamines can worsen urinary retention and glaucoma.
Hepatotoxicity
Despite widespread use, dimenhydrinate has not been linked to liver test abnormalities or to clinically apparent liver injury. The reason for its safety may relate to its limited duration of use.
Likelihood score: E (unlikely to be a cause of clinically apparent liver injury).
References on the safety and potential hepatotoxicity of antihistamines are given together after the Overview section on Antihistamines.
Drug Class: Antihistamines
PRODUCT INFORMATION
REPRESENTATIVE TRADE NAMES
Dimenhydrinate – Generic, Dramamine®
DRUG CLASS
Antihistamines
Product labeling at DailyMed, National Library of Medicine, NIH
CHEMICAL FORMULA AND STRUCTURE
DRUG | CAS REGISTRY NUMBER | MOLECULAR FORMULA | STRUCTURE |
---|---|---|---|
Dimenhydrinate | 523-87-5 | C17-H21-N-O.C7-H7-Cl-N4-O2 |
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- Review Antihistamines for motion sickness.[Cochrane Database Syst Rev. 2022]Review Antihistamines for motion sickness.Karrim N, Byrne R, Magula N, Saman Y. Cochrane Database Syst Rev. 2022 Oct 17; 10(10):CD012715. Epub 2022 Oct 17.
- The effects of TTS-scopolamine, dimenhydrinate, lidocaine, and tocainide on motion sickness, vertigo, and nystagmus.[Aviat Space Environ Med. 1985]The effects of TTS-scopolamine, dimenhydrinate, lidocaine, and tocainide on motion sickness, vertigo, and nystagmus.Pyykkö I, Padoan S, Schalén L, Lyttkens L, Magnusson M, Henriksson NG. Aviat Space Environ Med. 1985 Aug; 56(8):777-82.
- [Prevention and treatment of nausea and vomiting of motion sickness].[J Med Bord. 1953][Prevention and treatment of nausea and vomiting of motion sickness].AUBERTIN E. J Med Bord. 1953 Apr; 130(4):573-4.
- Transdermally administered scopolamine vs. dimenhydrinate. I. Effect on nausea and vertigo in experimentally induced motion sickness.[Acta Otolaryngol. 1985]Transdermally administered scopolamine vs. dimenhydrinate. I. Effect on nausea and vertigo in experimentally induced motion sickness.Pyykkö I, Schalén L, Jäntti V. Acta Otolaryngol. 1985 May-Jun; 99(5-6):588-96.
- Review Promethazine.[LiverTox: Clinical and Researc...]Review Promethazine.. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. 2012
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