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Show detailsContinuing Education Activity
Vertebral artery dissection (VAD) is a rare cause of stroke in the general population, but one of the more common causes of stroke in patients younger than 45 years of age. Its signs and symptoms can be vague, making diagnosis difficult. Spontaneous dissections have been reported, but incidental minor trauma typically precipitates this potentially dangerous condition. Often neck distortion caused by chiropractic manipulation, bending of the neck, or blunt trauma causes the dissection. The dissection of the artery may ultimately lead to a stroke which is often delayed for days following the acute dissection. This activity reviews the evaluation and management of patients with vertebral artery dissection and highlights the role of interprofessional team members in collaborating to provide well-coordinated care and enhance outcomes for affected patients.
Objectives:
- Outline the etiology of vertebral artery dissection.
- Describe the presentation of a patient with vertebral artery dissection.
- Summarize the treatment options for vertebral artery dissection.
- Explain the importance of improving care coordination among interprofessional team members to improve outcomes for patients affected by vertebral artery dissection.
Introduction
Vertebral artery dissection (VAD) is a rare cause of stroke in the general population; however, represents one of the more common causes of stroke in patients younger than 45 years of age. Its signs and symptoms can be vague, and diagnosis can be elusive. [1][2][3] Spontaneous dissections have been reported. However, incidental minor trauma often precipitates this potentially dangerous condition. Often some neck distortion such as chiropractic manipulation, bending of the neck, or blunt trauma causes the dissection. The dissection of the artery may ultimately lead to a stroke which often can be delayed for days following the acute dissection.
The majority of dissections are intracranial. It is estimated that vertebral artery dissection may be responsible for at least 20% of ischemic strokes in young people.
Etiology
Patients typically report minor, rather innocuous precipitating events before the onset of symptoms. Coughing, vomiting, chiropractic procedures, and blunt trauma are likely initiating events. It is estimated that 1 in 20,000 cervical spine manipulations cause a stroke. [4][5][6]Blunt trauma to the neck is the most common reported precipitating event. Patients with connective tissue disorders are also at increased risk. Ehlers-Danlos syndrome is the most common connective tissue disorder that can cause vertebral artery dissection. When patients with serious cervical cord injury or spine fractures are screened for vertebral artery injury approximately 20 to 40% will demonstrate traumatic occlusion. Interestingly, this occlusion tends to be asymptomatic, as opposed to dissection, and its management is controversial.
Other risk factors for vertebral artery dissection include:
- Yoga
- Nose blowing
- Painting the ceiling
- Judo, wrestling
- Hypertension
- Fibromuscular dysplasia
- Female gender
- Use of the birth control pill
- Cystic medial necrosis
- Vasculitis
- Postpartum[7]
Epidemiology
It is estimated that vertebral artery dissection is the cause of approximately 2% of all ischemic strokes. However, in middle-aged and younger patients (30 to 45 years of age), it is believed to be as high as 10% to 25%, representing a significant population affected by this condition. The combined incidence of both vertebral artery and carotid artery dissections is estimated to be 2.6 per 100,000. Carotid artery dissections are three to five times more common than vertebral artery dissections. It should be noted that chiropractors dismiss the association between manipulation and vertebral artery dissection on the grounds that the dissection is the cause of neck pain and the reason why the patients seek out chiropractic care. There is no conclusive evidence linking the two leading some medical associations only to suggest a causative link.
Pathophysiology
Vertebral artery anatomy
- Segment 1 takes off at the first branch of the subclavian artery until it reaches the foramina of C5-C6.
- Segment 2 runs within the transverse foramina from C5/C6 until C2.
- Segment 3 is the tortuous segment that starts at the transverse foramina of C2 and runs in the posterolateral part, looping around C1 and then passing between the atlas and the occiput. This segment of the artery is encased with nerves, muscles, and the atlanto-occipital membrane.
- Segment 4 is the intracranial segment; it pierces the dura at the foramen magnum runs until the junction of the medulla and pons; here it merges with the basilar artery.
The majority of spontaneous dissections occur in segment 3, which may extend and involve segment 4.
The arterial anatomy consists of three layers named the intimal (innermost), the media (middle), and the adventitia (outermost layer). Dissection occurs when the structural integrity of the arterial wall is compromised. Intimal tears lead to arterial blood dissecting between the layers of the arterial wall. The blood within the arterial wall precipitates hematoma and clot formation.[8] The subsequent compromise in arterial blood flow secondary to the stenosis then leads to the symptoms of vertebral artery dissection and ultimately, stroke. Vertebral artery dissection can be either extracranial or intracranial. Extracranial dissections usually involve the distal extracranial segment near the atlas and axis. Intracranial dissections are often associated with subarachnoid hemorrhage and carry a much worse prognosis. Neurological sequelae of both extracranial and intracranial dissections may result from cerebral ischemia due to thromboembolism, hypoperfusion, or a combination of both. However, thromboembolism rather than hypoperfusion is considered the major cause of ischemic symptoms.
History and Physical
History
Clinical presentation is typically acute and severe unilateral neck pain and/or a headache. Minor neck trauma often precipitates the pain. The pain is typically in the occipital-cervical area of the neck or head. Often the trauma is minor in nature.
Neurological symptoms are often delayed and may not be present at all. However, 70% of patients will have some type of neurological deficit which may present late
Lateral medullary syndromes (Wallenberg Syndrome) and cerebellar infarctions are the most common location for strokes. Wallenberg Syndrome is defined by sensory deficits affecting the trunk and extremities on the opposite side of the infarction and sensory deficits affecting the face and cranial nerves on the same side as the infarction. When neurological symptoms are present, dizziness, ataxia, dysphagia (cranial nerves 9 and 10), disequilibrium, unilateral hearing loss, dysarthria, diplopia, and vertigo are the predominant symptoms.
Extracranial dissections often have a bruit present. The bruit has even been reported on the contralateral side secondary to increased collateral blood flow. What often distinguishes this type of patient from those with cerebellar infarctions secondary to atherosclerotic disease is the age of the patient and the presence of pain. When the dissection is intracranial, a subarachnoid hemorrhage is present 50% of the time. This group of patients has severe neurological symptoms a much worse prognosis than those with extracranial dissections.
Physical Exam
- Nystagmus
- Truncal ataxia
- Ipsilateral loss of taste (hypogeusia), horner syndrome, impairment of proprioception and fine touch
- Contralateral impairment in thermal and pain sensation in the extremities
- Tongue deviation to the side of the lesion
- Internuclear ophthalmoplegia
Evaluation
MRI rivals angiography for establishing the diagnosis but is not readily available to most. CT and CTA are often the first investigations obtained. CT scan can demonstrate posterior fossa ischemia or subarachnoid hemorrhage. It may also identify an occluded vertebral artery or mural thrombus. CTA, however, is superior to CT scan and should be performed. CTA more easily identifies irregularity of the vascular lumen or thickening of the arterial wall. CTA is the initial test of choice. Vascular Duplex scanning demonstrates abnormal flow in 95% of patients. However, it shows evidence specific to dissection in only 20% of patients.[9]
MRI may detect an intimal flap and luminal thrombosis. Sometimes hyperintensity of the vessel wall may be visualized on T1 weighted images and are considered pathognomonic.
A cerebral angiogram may be required if the MRI and CT scan have failed to reveal any pathology
Routine blood work including coagulation profile should be obtained.
If CT reveals the absence of hemorrhage, then anticoagulation can be initiated.
Treatment / Management
For those patients that survive the initial dissection, the prognosis is usually good. Approximately 10% of patients die initially.
The goal of management is to prevent stroke, which is the complication of vertebral artery dissection. Management is done with anticoagulation, typically heparin. If there are no contraindications, then thrombolytic therapy can be started as long as the time is within 4.5 hours from the onset of symptoms.
In one clinical follow-up study, 80% achieved a full recovery. Death is typically secondary to extensive intracranial dissection, brainstem infarction, or subarachnoid hemorrhage. Most dissections will resolve over time with no neurological deficits. Be advised however that when the dissection is intracranial or extends intracranially, the risk of subarachnoid hemorrhage increases significantly and anticoagulation is contraindicated. [10][11][12]Endovascular or surgical treatments are reserved for patients with concomitant complications or those whose maximal medical therapy has been unsuccessful.
Admission is required for all patients with vertebral artery dissection. Close monitoring of neurological deficits is vital.
Today technological advances have permitted the use of endovascular therapies to manage vertebral artery dissection. However, the role of this therapy does remain controversial as most patients can be managed with anticoagulation therapy. In addition, most dissections do a repair on their own. Thus, endovascular therapy is best reserved for patients who are not candidates for thrombolytics and/or have a subarachnoid hemorrhage.
Surgery in the form of bypass graft is rarely done and not always successful.
Secondary prevention strategies include reducing risk by targeting and modifying vascular risk factors. Aspirin is used as preventative therapy is aspirin for most etiologies. For atrial fibrillation, anticoagulation is recommended. Most stroke patients, including young adults, should be treated with statin therapy.[13]
Differential Diagnosis
- Cervical spine fracture evaluation
- Cervical strain
- Emergent management of subarachnoid hemorrhage
- Migraine headache
- Stroke, hemorrhage
- Stroke, ischemia
- Tension headache
- Vasculitis affecting the vertebrobasilar circulation
- Vertebrobasilar atherothrombotic disease
Prognosis
For patients who do survive the initial acute extracranial dissection, the prognosis is good with complete recovery in nearly 80-90% of patients. However, at least 10% will develop recurrent attacks, a major stroke, or death. Patients who have severe neurological deficits at the time of presentation usually do have a poor prognosis. Follow-up angiographic studies have revealed healing in about 60% of patients.
Patients who develop an intracranial dissection have a poor prognosis. Those who present with altered consciousness and neurological deficits do poorly. Intracranial vertebral dissections are often associated with brainstem infarctions, subarachnoid hemorrhage, and death.
Prognosis may be very different for young patients without comorbidities like hypertension, diabetes, and smoking compared to those who have them.
Complications
- Cerebellar and brain stem infarction
- Subarachnoid hemorrhage
- Vertebral artery pseudoaneurysm leading to compression neuropathy of the cranial nerves.
Postoperative and Rehabilitation Care
Patients need to be followed every 3 to 6 months if they have symptoms or until imaging shows complete resolution. How long to administer anticoagulation therapy is not yet known but at least 6 months.
Pearls and Other Issues
A headache or neck pain associated with vertebral artery dissection may precede the development of neurological symptoms by as long as 14 days. Patients may report vague neurological symptoms associated with the pain that may be transient. The problem for the emergency department physician is that when the workup is initiated for a severe headache or neck pain, the CT scan and lumbar puncture may be negative. These patients are often diagnosed with a headache or even transient ischemic attack (TIA), delaying diagnosis and treatment. The severe pain remains the hallmark and cannot be ignored. Further neurologic imaging with CTA or MRI must be performed if clinical suspicion is high. Patients with vertebral artery dissection must be admitted to the hospital for close neurological monitoring and if indicated, anticoagulation. Surgery is very rarely indicated.
Enhancing Healthcare Team Outcomes
The diagnosis and treatment of vertebral artery dissection are not simple and best managed by an interprofessional team that includes a radiologist, emergency department physician, nurse practitioner, neurologist, and vascular surgeon. Once imaging has made the diagnosis, the treatment depends on patient symptoms.
For those patients that survive the initial dissection, the prognosis is usually good. Approximately 10% of patients die initially. In one clinical follow-up study, 80% achieved a full recovery. Death is typically secondary to extensive intracranial dissection, brainstem infarction, or subarachnoid hemorrhage. The goal of management is to prevent stroke, which is the complication of vertebral artery dissection. Management is done with anticoagulation, typically heparin. For those who have neurological deficits, appropriate rehabilitation therapy is necessary. The pharmacist should educate the patient on medication compliance, managing blood pressure, and discontinuing smoking. The pharmacist should also monitor the INR to ensure that it is in the therapeutic range.
Endovascular or surgical treatments are reserved for patients with concomitant complications or those whose maximal medical therapy has been unsuccessful. Most dissections will resolve over time with no neurological deficits. Close communication with the team members is vital if one wants to improve outcomes.
The recovery can be prolonged and full recovery is often not possible.[3][14]
Review Questions
References
- 1.
- Zhou Y, Wang L, Zhang JR, Zhou K, Shuai J, Gong ZL, Liu Y, Wei F, Han YF, Shen L, Yang QW. Angioplasty and stenting for severe symptomatic atherosclerotic stenosis of intracranial vertebrobasilar artery. J Clin Neurosci. 2019 May;63:17-21. [PubMed: 30850180]
- 2.
- Kim MK, Lim YC. Conservative Management of Unruptured Spontaneous Intracranial Vertebral Artery Dissection. World Neurosurg. 2019 Jun;126:e402-e409. [PubMed: 30822585]
- 3.
- Markus HS, Levi C, King A, Madigan J, Norris J., Cervical Artery Dissection in Stroke Study (CADISS) Investigators. Antiplatelet Therapy vs Anticoagulation Therapy in Cervical Artery Dissection: The Cervical Artery Dissection in Stroke Study (CADISS) Randomized Clinical Trial Final Results. JAMA Neurol. 2019 Jun 01;76(6):657-664. [PMC free article: PMC6563567] [PubMed: 30801621]
- 4.
- Saw AE, McIntosh AS, Kountouris A, Newman P, Gaida JE. Vertebral Artery Dissection in Sport: A Systematic Review. Sports Med. 2019 Apr;49(4):553-564. [PubMed: 30758815]
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- Walsh BA, Gregorie WD, Whittle JS. Deconstructing Dissections: A Case Report and Review of Blunt Cerebrovascular Injury of the Neck. Case Rep Emerg Med. 2018;2018:6120781. [PMC free article: PMC6106916] [PubMed: 30174964]
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- Hu Y, Du J, Liu Z, Wu H, Ding J, Jian F. Vertebral artery dissection caused by atlantoaxial dislocation: a case report and review of literature. Childs Nerv Syst. 2019 Jan;35(1):187-190. [PubMed: 30109422]
- 7.
- Finley A, Rogers B, Richards T, Vogel H. Postpartum vertebral artery dissection. BMJ Case Rep. 2015 Nov 24;2015 [PMC free article: PMC4680301] [PubMed: 26604230]
- 8.
- Yun SY, Heo YJ, Jeong HW, Baek JW, Choo HJ, Seo JH, Kim ST, Lee JY, Jin SC. Spontaneous intracranial vertebral artery dissection with acute ischemic stroke: High-resolution magnetic resonance imaging findings. Neuroradiol J. 2018 Jun;31(3):262-269. [PMC free article: PMC5958508] [PubMed: 29565222]
- 9.
- McNally JS, Hinckley PJ, Sakata A, Eisenmenger LB, Kim SE, De Havenon AH, Quigley EP, Iacob E, Treiman GS, Parker DL. Magnetic Resonance Imaging and Clinical Factors Associated With Ischemic Stroke in Patients Suspected of Cervical Artery Dissection. Stroke. 2018 Oct;49(10):2337-2344. [PMC free article: PMC6208137] [PubMed: 30355108]
- 10.
- Turner RC, Lucke-Wold BP, Boo S, Rosen CL, Sedney CL. The potential dangers of neck manipulation & risk for dissection and devastating stroke: An illustrative case & review of the literature. Biomed Res Rev. 2018;2(1) [PMC free article: PMC6016850] [PubMed: 29951644]
- 11.
- Urasyanandana K, Songsang D, Aurboonyawat T, Chankaew E, Withayasuk P, Churojana A. Treatment outcomes in cerebral artery dissection and literature review. Interv Neuroradiol. 2018 Jun;24(3):254-262. [PMC free article: PMC5967189] [PubMed: 29433365]
- 12.
- Stack CA, Cole JW. A Diagnostic Approach to Stroke in Young Adults. Curr Treat Options Cardiovasc Med. 2017 Sep 25;19(11):84. [PubMed: 28948451]
- 13.
- Takahara M, Ogata T, Abe H, Higashi T, Morishita T, Takano K, Inoue T. The Comparison of Clinical Findings and Treatment Between Unilateral and Bilateral Vertebral Artery Dissection. J Stroke Cerebrovasc Dis. 2019 May;28(5):1192-1199. [PubMed: 30711415]
Disclosure: Todd Britt declares no relevant financial relationships with ineligible companies.
Disclosure: Shashank Agarwal declares no relevant financial relationships with ineligible companies.
- Spontaneous Bilateral Dissection of the Vertebral Artery: A Case Report.[Cureus. 2020]Spontaneous Bilateral Dissection of the Vertebral Artery: A Case Report.Almuaigel MF, Althwanay A, Alamri A. Cureus. 2020 Jul 21; 12(7):e9310. Epub 2020 Jul 21.
- Twists and Turns: A Chiropractic Roller Coaster Experience Unraveling the Intricacies of Bilateral Vertebral Artery Dissection.[Cureus. 2024]Twists and Turns: A Chiropractic Roller Coaster Experience Unraveling the Intricacies of Bilateral Vertebral Artery Dissection.Iwamoto S, Hsu MD, Ta APD, Leo A, Chu H, Chu G. Cureus. 2024 Feb; 16(2):e54990. Epub 2024 Feb 26.
- Spontaneous Vertebral Artery Dissection Is an Under-Recognized Cause of Stroke in Young Patients: Two Case Reports and Review.[Cureus. 2020]Spontaneous Vertebral Artery Dissection Is an Under-Recognized Cause of Stroke in Young Patients: Two Case Reports and Review.Elkady A, Ghazal S, Alanzi A, Madkour M, Bakheet MF Sr. Cureus. 2020 Jul 14; 12(7):e9183. Epub 2020 Jul 14.
- Review Cervical arterial dissections and association with cervical manipulative therapy: a statement for healthcare professionals from the american heart association/american stroke association.[Stroke. 2014]Review Cervical arterial dissections and association with cervical manipulative therapy: a statement for healthcare professionals from the american heart association/american stroke association.Biller J, Sacco RL, Albuquerque FC, Demaerschalk BM, Fayad P, Long PH, Noorollah LD, Panagos PD, Schievink WI, Schwartz NE, et al. Stroke. 2014 Oct; 45(10):3155-74. Epub 2014 Aug 7.
- Review Self-inflicted vertebral artery dissection: a case report and review of literature.[Conn Med. 2013]Review Self-inflicted vertebral artery dissection: a case report and review of literature.Kowlgi NG, Gowani SA, Mota P, Haider J. Conn Med. 2013 Oct; 77(9):551-2.
- Vertebral Artery Dissection - StatPearlsVertebral Artery Dissection - StatPearls
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