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Entyvio (Vedolizumab) [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2016 Dec.

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Entyvio (Vedolizumab) [Internet].

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Table 1Cost Comparison Table of Biologics for the Treatment of Crohn’s Disease

Drug/ComparatorStrengthDosage
Form
PriceRecommended DoseaDrug Cost in
Year 1
Average
Drug Cost
Subsequent
Years
Vedolizumab
(Entyvio)
300 mgVial for IV infusion$3,290.00b300 mg at weeks 0, 2, and 6, followed by every 8 weeks thereafter$26,320$21,458
TNF Alpha Inhibitors
Adalimumab
(Humira)
40 mgPen for SC injection740.36160 mg week 0, 80 mg week 2, 40 mg week 4 and every 2 weeks thereafter$22,211$19,315
Infliximab
(Remicade)
100 mgVial for IV infusion$987.565 mg/kg at weeks 0, 2, and 6, then every 8 weeks thereafter

May be increased to 10 mg/kg every 8 weeks in patients who have lost response
$31,602 to $46,415$25,765 to $,45,088
Infliximab
(Inflectra)
100 mgVial for IV infusion$$525.00c5 mg/kg at weeks 0, 2, and 6, then every 8 weeks thereafter

May be increased to 10 mg/kg every 8 weeks in patients who have lost response
$16,800 to $24,675$13,697 to $23,970

IV = intravenous; ODB = Ontario Drug Benefit; SC = subcutaneous; TNF alpha = tumour necrosis factor alpha.

Note: All prices are from the ODB Formulary Exceptional Access Program (July 2016) unless otherwise indicated.

a

Based on doses recommended in the appropriate product monographs.2,810

b

Manufacturer’s submitted and current market price.

c

ODB Formulary list price.

From: SUMMARY

Copyright © CADTH 2016.

Except where otherwise noted, this work is distributed under the terms of a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International licence (CC BY-NC-ND), a copy of which is available at http://creativecommons.org/licenses/by-nc-nd/4.0/

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