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Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
Figure 8Probe development strategy, post-uHTS
- PMCPubMed Central citations
- PubChem BioAssay for Chemical ProbePubChem BioAssay records reporting screening data for the development of the chemical probe(s) described in this book chapter
- PubChem SubstanceRelated PubChem Substances
- PubMedLinks to PubMed
- Review Insulin-degrading enzyme: new therapeutic target for diabetes and Alzheimer's disease?[Ann Med. 2016]Review Insulin-degrading enzyme: new therapeutic target for diabetes and Alzheimer's disease?Pivovarova O, Höhn A, Grune T, Pfeiffer AF, Rudovich N. Ann Med. 2016 Dec; 48(8):614-624. Epub 2016 Jun 19.
- Optimization of peptide hydroxamate inhibitors of insulin-degrading enzyme reveals marked substrate-selectivity.[J Med Chem. 2013]Optimization of peptide hydroxamate inhibitors of insulin-degrading enzyme reveals marked substrate-selectivity.Abdul-Hay SO, Lane AL, Caulfield TR, Claussin C, Bertrand J, Masson A, Choudhry S, Fauq AH, Maharvi GM, Leissring MA. J Med Chem. 2013 Mar 28; 56(6):2246-55. Epub 2013 Mar 15.
- Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin.[PLoS One. 2010]Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin.Leissring MA, Malito E, Hedouin S, Reinstatler L, Sahara T, Abdul-Hay SO, Choudhry S, Maharvi GM, Fauq AH, Huzarska M, et al. PLoS One. 2010 May 7; 5(5):e10504. Epub 2010 May 7.
- Molecular basis for the thiol sensitivity of insulin-degrading enzyme.[Proc Natl Acad Sci U S A. 2008]Molecular basis for the thiol sensitivity of insulin-degrading enzyme.Neant-Fery M, Garcia-Ordoñez RD, Logan TP, Selkoe DJ, Li L, Reinstatler L, Leissring MA. Proc Natl Acad Sci U S A. 2008 Jul 15; 105(28):9582-7. Epub 2008 Jul 8.
- Review Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis.[Neurobiol Aging. 2006]Review Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis.Qiu WQ, Folstein MF. Neurobiol Aging. 2006 Feb; 27(2):190-8. Epub 2005 Feb 17.
- Figure 8, Probe development strategy, post-uHTS - Probe Reports from the NIH Mol...Figure 8, Probe development strategy, post-uHTS - Probe Reports from the NIH Molecular Libraries Program
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